Flegal, KM, Carroll, MD, Ogden, CL, Curtin, LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA
2010; 303: 235–41.
Wang, YC, McPherson, K, Marsh, T, Gortmaker, SL, Brown, M. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet
2011; 378: 815–25.
Farmer, A, Korszun, A, Owen, MJ, Craddock, N, Jones, L, Jones, I, et al. Medical disorders in people with recurrent depression. Br J Psychiatry
2008; 192: 351–5.
Zhang, C, Rexrode, KM, van Dam, RM, Li, TY, Hu, FB. Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality. Circulation
2008; 117: 1658–67.
de Wit, L, Luppino, F, van Straten, A, Penninx, B, Zitman, F, Cuijpers, P. Depression and obesity: a meta-analysis of community-based studies. Psychiatry Res
2010; 178: 230–5.
Luppino, FS, de Wit, LM, Bouvy, PF, Stijnen, T, Cuijpers, P, Penninx, BWJH, et al. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry
2010; 67: 220.
Anderson, SE, Cohen, P, Naumova, EN, Jacques, PF, Must, A. Adolescent obesity and risk for subsequent major depressive disorder and anxiety disorder: prospective evidence. Psychosom Med
2007; 69: 740–7.
Roberts, RE, Deleger, S, Strawbridge, WJ, Kaplan, GA. Prospective association between obesity and depression: evidence from the Alameda County Study. Int J Obes
2003; 27: 514–21.
Hickie, I, Scott, E, Naismith, S, Ward, P, Turner, K, Parker, G, et al. Late-onset depression: genetic, vascular and clinical contributions. Psychol Med
2001; 31: 1403–12.
Beydoun, MA, Wang, Y. Pathways linking socioeconomic status to obesity through depression and lifestyle factors among young US adults. J Affect Disord
2010; 123: 52–63.
Sheehan, NA, Didelez, V, Burton, PR, Tobin, MD. Mendelian randomisation and causal inference in observational epidemiology. PLoS Med
2008; 5: e177.
Jokela, M, Elovainio, M, Keltikangas-Jarvinen, L, Batty, GD, Hintsanen, M, Seppala, I, et al. Body mass index and depressive symptoms: instrumental-variables regression with genetic risk score. Genes Brain Behav
Kivimaki, M, Jokela, M, Hamer, M, Geddes, J, Ebmeier, K, Kumari, M, et al. Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: the Whitehall II Study, 1985-2004. Am J Epidemiol
2011; 173: 421–9.
Lawlor, DA, Harbord, RM, Tybjaerg-Hansen, A, Palmer, TM, Zacho, J, Benn, M, et al. Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53,221 adults. J Intern Med
2011; 269: 525–37.
Speliotes, EK, Willer, CJ, Berndt, SI, Monda, KL, Thorleifsson, G, Jackson, AU, et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet
2010; 42: 937–48.
Palmer, TM, Lawlor, DA, Harbord, RM, Sheehan, NA, Tobias, JH, Timpson, NJ, et al. Using multiple genetic variants as instrumental variables for modifiable risk factors. Stat Methods Med Res
2012; 21: 223–42.
Farmer, A, Breen, G, Brewster, S, Craddock, N, Gill, M, Korszun, A, et al. The Depression Network (DeNT) Study: methodology and sociodemographic characteristics of the first 470 affected sibling pairs from a large multi-site linkage genetic study. BMC Psychiatry
2004; 4: 42.
Cohen-Woods, S, Gaysina, D, Craddock, N, Farmer, A, Gray, J, Gunasinghe, C, et al. Depression Case Control (DeCC) Study fails to support involvement of the muscarinic acetylcholine receptor M2 (CHRM2) gene in recurrent major depressive disorder. Hum Mol Genet
2009; 18: 1504–9.
Uher, R, Huezo-Diaz, P, Perroud, N, Smith, R, Rietschel, M, Mors, O, et al. Genetic predictors of response to antidepressants in the GENDEP project. Pharmacogenomics J
2009; 9: 225–33.
Wing, JK, Babor, T, Brugha, T, Burke, J, Cooper, J, Giel, R, et al. SCAN: Schedules for Clinical Assessment in Neuropsychiatry. Arch Gen Psychiatry
1990; 47: 589.
McGuffin, P, Katz, R, Aldrich, J. Past and present state examination: the assessment of ‘lifetime ever'psychopathology. Psychol Med
1986; 16: 461–5.
Lewis, CM, Ng, MY, Butler, AW, Cohen-Woods, S, Uher, R, Pirlo, K, et al. Genome-wide association study of major recurrent depression in the UK population. Am J Psychiatry
2010; 167: 949–57.
Price, AL, Patterson, NJ, Plenge, RM, Weinblatt, ME, Shadick, NA, Reich, D. Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet
2006; 38: 904–9.
Glymour, MM, Tchetgen, EJ, Robins, JM. Credible Mendelian randomization studies: approaches for evaluating the instrumental variable assumptions. Am J Epidemiol
2012; 175: 332–9.
Goldberg, DP. The Detection of Psychiatric Illness by Questionnaire: A Technique for the Identification and Assessment of Non-Psychotic Psychiatric Illness. Oxford University Press, 1972.
Chaiton, M, Cohen, J, O'Loughlin, J, Rehm, J. A systematic review of longitudinal studies on the association between depression and smoking in adolescents. BMC Public Health
2009; 9: 356.
Beck, AT, Steer, RA, Brown, GK. Manual for the Beck Depression Inventory-II.
Psychological Corporation, 1996.
American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders (4th edn) . APA, 1994.
Wray, N, Pergadia, M, Blackwood, D, Penninx, B, Gordon, S, Nyholt, D, et al. Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned. Mol Psychiatry
2012; 17: 36–48.
Serretti, A, Mandelli, L. Antidepressants and body weight: a comprehensive review and meta-analysis. J Clin Psychiatry
2010; 71: 1259–72.
Puhl, RM, Heuer, CA. Obesity stigma: important considerations for public health. Am J Public Health
2010; 100: 1019–28.
Penninx, BWJH, Milaneschi, Y, Lamer, F, Vogelzangs, N. Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile. BMC Med
2013; 11: 129.
Srinivasan, SR, Bao, W, Wattigney, WA, Berenson, GS. Adolescent overweight is associated with adult overweight and related multiple cardiovascular risk factors: the Bogalusa Heart Study. Metabolism
1996; 45: 235.
Guo, S, Huang, C, Maynard, LM, Demerath, E, Towne, B, Chumlea, WC, et al. Body mass index during childhood, adolescence and young adulthood in relation to adult overweight and adiposity: the Fels Longitudinal Study. Int J Obes Relat Metab Disord
2000; 24: 1628.
Mumby, HS, Elks, CE, Li, S, Sharp, SJ, Khaw, K-T, Luben, RN, et al. Mendelian randomisation study of childhood BMI and early menarche. J Obes
2011; 2011: 180729.
Pierce, BL, Ahsan, H, VanderWeele, TJ. Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants. Int J Epidemiol
2011; 40: 740–52.