Ng, M, Fleming, T, Robinson, M, Thomson, B, Graetz, N, Margono, C, et al. Global, regional, and national prevalence of
overweight and obesity in children and adults during 1980-2013: a
systematic analysis for the Global Burden of Disease Study
2014; 384: 766–81.
Fagiolini, A, Frank, E, Scott, JA, Turkin, S, Kupfer, DJ. Metabolic syndrome in bipolar disorder: findings
from the Bipolar Disorder Center for Pennsylvanians.
2005; 7: 424–30.
Shah, A, Shen, N, El-Mallakh, RS. Weight gain occurs after onset of bipolar illness in
overweight bipolar patients. Ann Clin
2006; 18: 239–41.
Fiedorowicz, JG, Palagummi, NM, Forman-Hoffman, VL, Miller del, D, Haynes, WG. Elevated prevalence of obesity, metabolic syndrome,
and cardiovascular risk factors in bipolar disorder.
Ann Clin Psychiatry
2008; 20: 131–7.
Sicras, A, Rejas, J, Navarro, R, Serrat, J, Blanca, M. Metabolic syndrome in bipolar disorder: a
cross-sectional assessment of a Health Management Organization
database. Bipolar Disord
2008; 10: 607–16.
Kim, B, Kim, SJ, Son, JI, Joo, YH. Weight change in the acute treatment of bipolar I
disorder: a naturalistic observational study of psychiatric
inpatients. J Affect Disord
Lee, NY, Kim, SH, Cho, B, Lee, YJ, Chang, JS, Kang, UG, et al. Patients taking medications for bipolar
disorder are more prone to metabolic syndrome than Korea's general
population. Prog Neuropsychopharmacol Biol
2010; 34: 1243–9.
Goldstein, BI, Liu, SM, Zivkovic, N, Schaffer, A, Chien, LC, Blanco, C. The burden of obesity among adults with bipolar
disorder in the United States. Bipolar
2011; 13: 387–95.
Ouchi, N, Parker, JL, Lugus, JJ, Walsh, K. Adipokines in inflammation and metabolic
disease. Nat Rev Immunol
Uysal, KT, Wiesbrock, SM, Marino, MW, Hotamisligil, GS. Protection from obesity-induced insulin resistance
in mice lacking TNF-alpha function.
1997; 389: 610–4.
Brain Development Cooperative Group.
Total and regional brain volumes in a population-based
normative sample from 4 to 18 years: the NIH MRI Study of Normal Brain
Development. Cereb Cortex
Gunstad, J, Paul, RH, Cohen, RA, Tate, DF, Spitznagel, MB, Gordon, E. Elevated body mass index is associated with
executive dysfunction in otherwise healthy adults.
Anstey, KJ, Cherbuin, N, Budge, M, Young, J. Body mass index in midlife and late-life as a risk
factor for dementia: a meta-analysis of prospective
studies. Obes Rev
Colman, RJ, Anderson, RM, Johnson, SC, Kastman, EK, Kosmatka, KJ, Beasley, TM, et al. Caloric restriction delays disease onset and
mortality in rhesus monkeys. Science
2009; 325: 201–4.
Siervo, M, Arnold, R, Wells, JC, Tagliabue, A, Colantuoni, A, Albanese, E, et al. Intentional weight loss in overweight and
obese individuals and cognitive function: a systematic review and
meta-analysis. Obes Rev
2011; 12: 968–83.
Fagiolini, A, Kupfer, DJ, Houck, PR, Novick, DM, Frank, E. Obesity as a correlate of outcome in patients with
bipolar I disorder. Am J Psychiatry
2003; 160: 112–7.
Kemp, DE, Gao, K, Chan, PK, Ganocy, SJ, Findling, RL, Calabrese, JR. Medical comorbidity in bipolar disorder:
relationship between illnesses of the endocrine/metabolic system and
treatment outcome. Bipolar Disord
2010; 12: 404–13.
Depp, CA, Strassnig, M, Mausbach, BT, Bowie, CR, Wolyniec, P, Thornquist, MH, et al. Association of obesity and treated
hypertension and diabetes with cognitive ability in bipolar disorder and
schizophrenia. Bipolar Disord
2014; 16: 422–31.
Bond, DJ, Ha, TH, Lang, DJ, Su, W, Torres, IJ, Honer, WG, et al. Body mass index-related regional gray and
white matter volume reductions in first-episode mania
patients. Biol Psychiatry
2014; 76: 138–45.
Kuswanto, CN, Sum, MY, Yang, GL, Nowinski, WL, McIntyre, RS, Sim, K. Increased body mass index makes an impact on brain
white-matter integrity in adults with remitted first-episode
mania. Psychol Med
2014; 44: 533–41.
Gigante, AD, Bond, DJ, Lafer, B, Lam, RW, Young, LT, Yatham, LN. Brain glutamate levels measured by magnetic
resonance spectroscopy in patients with bipolar disorder: a
meta-analysis. Bipolar Disord
2012; 14: 478–87.
Yatham, LN, Kauer-Sant'anna, M, Bond, DJ, Lam, RW, Tam, E. Course and outcome after the first manic episode in
patients with bipolar disorder: prospective 12-month data from the
Systematic Treatment Optimization Program for Early Mania (STOP-EM)
project. Can J Psychiatry
2009; 54: 105–12.
American Psychiatric Association.
Diagnostic and Statistical Manual of Mental Disorders (4th edn, text
Yatham, LN, Kennedy, SH, Parikh, SV, Schaffer, A, Beaulieu, S, Alda, M, et al. Canadian Network for Mood and Anxiety
Treatments (CANMAT) and International Society for Bipolar Disorders
(ISBD) collaborative update of CANMAT guidelines for the management of
patients with bipolar disorder: update 2013.
Sheehan, DV, Lecrubier, Y, Sheehan, KH, Amorim, P, Janavs, J, Weiller, E, et al. The Mini-International Neuropsychiatric
Interview (M.I.N.I.): the development and validation of a structured
diagnostic psychiatric interview for DSM-IV and ICD-10.
J Clin Psychiatry
1998; 59 (suppl 20):
Young, RC, Biggs, JT, Ziegler, VE, Meyer, DA. A rating scale for mania: reliability, validity and
sensitivity. Br J Psychiatry
1978; 133: 429–35.
Montgomery, SA, Åsberg, M. A new depression scale designed to be sensitive to
change. Br J Psychiatry
1979; 134: 382–9.
Overall, JE, Gorham, DR. The Brief Psychiatric Rating Scale.
Smith, SM, Jenkinson, M, Woolrich, MW, Beckmann, CF, Behrens, TE, Johansen-Berg, H, et al. Advances in functional and structural MR
image analysis and implementation as FSL.
2004; 23 (suppl 1):
Woolrich, MW, Jbabdi, S, Patenaude, B, Chappell, M, Makni, S, Behrens, T, et al. Bayesian analysis of neuroimaging data in
2009; 45 (suppl 1):
Posse, S, Otazo, R, Caprihan, A, Bustillo, J, Chen, H, Henry, PG, et al. Proton echo-planar spectroscopic imaging of
J-coupled resonances in human brain at 3 and 4 Tesla.
Magn Reson Med
2007; 58: 236–44.
Guh, DP, Zhang, W, Bansback, N, Amarsi, Z, Birmingham, CL, Anis, AH. The incidence of co-morbidities related to obesity
and overweight: a systematic review and meta-analysis.
BMC Public Health
2009; 9: 88.
Prospective Studies Collaboration.
Body-mass index and cause-specific mortality in 900 000
adults: collaborative analyses of 57 prospective studies.
2009; 373: 1083–96.
Berrington de Gonzalez, A, Hartge, P, Cerhan, JR, Flint, AJ, Hannan, L, MacInnis, RJ, et al. Body-mass index and mortality among 1.46
million white adults. N Engl J Med
2010; 363: 2211–9.
Wurtz, P, Wang, Q, Kangas, AJ, Richmond, RC, Skarp, J, Tiainen, M, et al. Metabolic signatures of adiposity in young
adults: mendelian randomization analysis and effects of weight
change. PLoS Med
Goldstein, BI, Kemp, DE, Soczynska, JK, McIntyre, RS. Inflammation and the phenomenology, pathophysiology,
comorbidity, and treatment of bipolar disorder: a systematic review of
the literature. J Clin Psychiatry
2009; 70: 1078–90.
Capuron, L, Miller, AH. Immune system to brain signaling:
2011; 130: 226–38.
Rao, JS, Harry, GJ, Rapoport, SI, Kim, HW. Increased excitotoxicity and neuroinflammatory
markers in postmortem frontal cortex from bipolar disorder
patients. Mol Psychiatry
2010; 15: 384–92.
Haarman, BC, Riemersma-Van der Lek, RF, de Groot, JC, Ruhe, HG, Klein, HC, Zandstra, TE, et al. Neuroinflammation in bipolar disorder – A
[C]-(R)-PK11195 positron emission tomography study.
Brain Behav Immun
2014; 40: 219–25.
Kurt, E, Guler, O, Serteser, M, Cansel, N, Ozbulut, O, Altinbaş, K, et al. The effects of electroconvulsive therapy on
ghrelin, leptin and cholesterol levels in patients with mood
disorders. Neurosci Lett
Harvey, J. Leptin: a diverse regulator of neuronal
function. J Neurochem
2007; 100: 307–13.
Andrews, ZB. The extra-hypothalamic actions of ghrelin on
neuronal function. Trends Neurosci
Signore, AP, Zhang, F, Weng, Z, Gao, Y, Chen, J. Leptin neuroprotection in the CNS: mechanisms and
therapeutic potentials. J Neurochem
2008; 106: 1977–90.
Harvey, J, Solovyova, N, Irving, A. Leptin and its role in hippocampal synaptic
plasticity. Prog Lipid Res
2006; 45: 369–78.
Opland, DM, Leinninger, GM, Myers, MG Jr. Modulation of the mesolimbic dopamine system by
leptin. Brain Res
Porter, RK AJ. Effects of leptin on mitochondrial ‘proton leak’ and
uncoupling proteins: implications for mammalian energy
metabolism. Proc Nutr Soc
1998; 57: 455–60.