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Psychotic and Depressive Symptoms in Parkinson's Disease a Study of the Growth Hormone Response to Apomorphine

  • John D. C. Mellers (a1), Niall P. Quinn (a2) and Maria A. Ron (a2)

Abstract

Background

The growth hormone (GH) response to apomorphine, thought to reflect central dopaminergic receptor sensitivity, has been reported as enhanced in acute schizophrenia. We investigated this response in relation to the psychotic episodes associated with Parkinson's disease (PD).

Method

The GH response to apomorphine was measured in three groups of patients with Parkinson's disease: those currently psychotic (n = 9), those with a past history of psychosis (n = 7) and those who had never been psychotic (n = 8).

Results

Apomorphine-induced GH response was not related to psychosis but was unexpectedly associated with measures of depression.

Conclusions

Visual hallucinations were a prominent feature in the psychotic patients and the atypical nature of these psychoses might explain why we found no evidence of dopaminergic sensitivity. Serotonergic dysfunction would be in keeping with this. Dopaminergic mechanisms may contribute to the minor depressive symptomatology seen in PD.

Copyright

Corresponding author

Dr Mellers, Section of Neuropsychiatry, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF

References

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Agid, Y., Javoy-Agid, F. & Ruberg, M. (1987) Biochemistry of neurotransmitters in Parkinson's disease. In Movement Disorders 2 (eds Marsden, C. D. & Fahn, S.), pp. 166230. London: Butterworths.
Ansseau, M., Von Frenckell, R., Cerfontaine, J. L., et al (1988) Blunted response of growth hormone to clonidine and apomorphine in endogenous depression. British Journal of Psychiatry, 153, 6571.
Birkmayer, W., Danielczyk, W., Neumayer, E., et al (1974) Nucleus ruber and L-dopa psychosis: biochemical post-mortem findings. Journal of Neural Transmission, 35, 93116.
Brown, R. G. & MacCarthy, B. (1990) Psychiatric morbidity in patients with Parkinson's disease. Psychological Medicine, 20, 7787.
Canter, C. J., De La Torre, R. & Mier, M. A. (1961) A method of evaluating disability in Parkinson's disease. Journal of Nervous and Mental Disease, 133, 143147.
Cheng, A. V. T., Ferrier, I. N., Morris, C. M., et al (1991) Cortical serotonin-S2 receptor binding in Lewy body dementia, Alzheimer's disease and Parkinson's diseases. Journal of the Neurological Sciences, 106, 5055.
Corn, T., Hale, A. S., Thompson, C., et al (1984) A comparison of the GH responses to clonidine and apomorphine in the same endogenously depressed patients. British Journal of Psychiatry, 144, 636639.
Cummings, J. L. (1992) Neuropsychiatric complications of drug treatment of Parkinson's disease. In Parkinson's Disease. Neurobehavioural Aspects (eds Huber, S. J. & Cummings, J. L.), pp. 313327. Oxford: Oxford University Press.
Ferrier, I. N., Johnstone, E. C. & Crow, T. J. (1984) Hormonal effects of apomorphine in schizophrenia. British Journal of Psychiatry, 144, 349357.
Folstein, M. F., Folstein, S. E. & McHugh, P. R. (1975) Mini-Mental State Examination. Journal of Psychiatric Research, 12, 189198.
Gibb, W. R. G. & Lees, A. J. (1988) The relevance of the Lewy body to the pathogenesis of Parkinson's disease. Journal of Neurology, Neurosurgery & Psychiatry, 51, 745752.
Hoehn, M. M. & Yahr, M. D. (1967) Parkinsonism: onset, progression and mortality. Neurology, 17, 427442.
Jimerson, D. C., Cutler, N. R., Post, R. M., et al (1984) Neuroendocrine responses to apomorphine in depressed and healthy control subjects. Psychiatry Research, 13, 112.
Klawans, H. L., Goetz, C., Nausieda, P. A., et al (1977) Levodopa-induced dopamine receptor hypersensitivity. Annals of Neurology, 2, 125129.
Pitchot, W., Ansseau, M., Moreno, A. G., et al (1992) Dopaminergic function in panic disorder: comparison with major and minor depression. Biological Psychiatry, 32, 10041011.
Sadzot, B., Baraban, J. M., Glennon, R. A., et al (1989) Hallucinogenic drug interactions at human brain 5-HT2 receptors: implications for treating LSD-induced hallucinogenesis. Psychopharmacology, 98, 495499.
Stein, M. B., Heuser, I. J., Juncos, J. L., et al (1990) Anxiety disorders in patients with Parkinson's disease. American Journal of Psychiatry, 147, 217220.
Webster, D. D. (1968) Critical analysis of the disability in Parkinson's disease. Modern Treatments, 5, 257282.
Wieck, A., Kumar, R., Hirst, A. D., et al (1991) Increased sensitivity of dopamine receptors and recurrence of affective psychosis after childbirth. British Medical Journal, 303, 613616.
Wing, J. K., Cooper, J. E. & Sartorius, N. (1973) The Measurement and Classification of Psychiatric Symptoms. An Instruction for the Present State Examination and Catego Program. Cambridge: Cambridge University Press.
Zemlan, F. P., Hirschowitz, J. & Garver, D. L. (1986) Relation of clinical symptoms to apomorphine-stimulated growth hormone release in mood-incongruent psychotic patients. Archives of General Psychiatry, 43, 11621167.

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Psychotic and Depressive Symptoms in Parkinson's Disease a Study of the Growth Hormone Response to Apomorphine

  • John D. C. Mellers (a1), Niall P. Quinn (a2) and Maria A. Ron (a2)

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Psychotic and Depressive Symptoms in Parkinson's Disease a Study of the Growth Hormone Response to Apomorphine

  • John D. C. Mellers (a1), Niall P. Quinn (a2) and Maria A. Ron (a2)
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