Skip to main content Accessibility help
×
Home

A Psychological and Physiological Evaluation of the Effects of Intravenous Diazepam

  • Desmond Kelly (a1), Robert Pik (a1) and Char-nie Chen (a1)

Extract

Intravenous diazepam is widely used both in general medicine and in psychiatry. It is used to produce sedation in psychiatric emergencies and to enhance systematic desensitization; it is also employed in the treatment of drug-induced dystonic reactions, status epilepticus and tetanus, and as an anaesthetic agent. Its property of relieving severe muscle spasm has been utilized to treat patients suffering from ‘stiff-man syndrome‘.

Copyright

Corresponding author

Now at: Department of Physiology, University College London, Gower Street, London WC 1

Footnotes

Hide All

A synopsis of this paper was published in the October 1972 Journal.

Footnotes

References

Hide All
Arrigo, A., Jann, G., and Tonali, P. (1965). ‘Some aspects of the action of Valium and of Librium on the electrical activity of the rabbit brain.Archives Internationales de Pharmacodynamie, 154, 364–73.
Chambiras, P. G. (1970). ‘General anaesthesia and sedation: a review.Australian Dental Journal, 15, 44–9.
Clarke, R. S. J., and Hellon, R. F. (1957). ‘Venous occlusion in forearm and hand measured by strain gauge and volume plethysmography.Clinical Science, 16, 103–17.
Clyde, D. J. (1963). Manual for the Clyde Mood Scale. Coral Gables, Florida: University of Miami.
Crown, S., and Crisp, A. H. (1966). ‘A short clinical diagnostic self-rating scale for psychoneurotic patients.British Journal of Psychiatry, 112, 917–23.
Katz, J., Finestone, S. C., and Pappas, M. T. (1967). ‘Circulatory responses to tilting after intravenous diazepam in volunteers.Anaesthesia and Analgesia, 46, 243–6.
Kelly, D. H. W. (1967). ‘The technique of forearm plethysmography for assessing anxiety.Journal of Psychosomatic Research, 10, 373–82.
Kelly, D. H. W., Brown, C. C., and Shaffer, J. W. (1969). ‘A clinical physiological and psychological evaluation of chlordiazepoxide.British Journal of Psychiatry, 115, 1387–92.
Kelly, D. H. W., Mitchell-Heggs, N., and Sherman, D. (1971). ‘Anxiety and the effects of sodium lactate assessed clinically and physiologically.British Journal of Psychiatry, 119, 129–41.
Lader, M. H. (1970). Personal communication.
Lader, M. H. and Wing, L. (1966). Physiological Measures, Sedative Drugs and Morbid Anxiety. London: Oxford University Press.
Parkes, M. W. (1968). ‘The pharmacology of diazepam’, in Diazepam in Anaesthesia (eds. P. F. Knight and C. G. Burgess). Bristol: John Wright and Sons.
Rosenberg, C. M., and Buttsworth, F. J. (1969). ‘Effects of diazepam on anxiety as measured by forearm blood flow.Australian and New Zealand Journal of Psychiatry, 3, 8991.
Whitney, R. J. (1953). ‘The measurement of volume changes in human limbs.Journal of Physiology, 121, 127.
Zbinden, G., and Randall, L. O. (1967). ‘Pharmacology of benzodiazepines: laboratory and clinical correlations.Advances in Pharmacology, 5, 213–91.

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

A Psychological and Physiological Evaluation of the Effects of Intravenous Diazepam

  • Desmond Kelly (a1), Robert Pik (a1) and Char-nie Chen (a1)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *