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Oral olanzapine versus oral haloperidol in the maintenance treatment of schizophrenia and related psychoses

  • Pierre V. Tran (a1), Mary Anne Dellva (a1), Gary D. Tollefson (a1), Anita L. Wentley (a1) and Charles M. Beasley (a1)...

Abstract

Background

Three studies compared olanzapine and haloperidol given orally in maintenance therapy for schizophrenia and related psychoses.

Method

Data were from double-blind extensions of acute studies. The subjects met criteria for schizophrenia, schizophreniform disorder or schizoaffective disorder. Subjects had responded to acute therapy (Brief Psychiatric Rating Scale total score decreased $ 40% from baseline (Studies 1, 2, and 3) or was $ 18 (Studies I and 2)) and were out-patients at their last acute phase visit. Relapse was defined as hospitalisation for psychopathology. Subjects treated with olanzapine in the three studies were pooled to form the olanzapine group and subjects treated with haloperidol were pooled to form the haloperidol group.

Results

Olanzapine-treated subjects experienced less relapse (P=0.034). The Kaplan-Meier estimated one-year risk of relapse was 19.7% with olanzapine and 28% with haloperidol.

Conclusion

Olanzapine was superior to haloperidol in the maintenance therapy of schizophrenia and related psychoses.

Copyright

Corresponding author

Dr Pierre V. Tran, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0538, Indianapolis, IN 46285. Tel: 317-276-4491. Fax: 317-277-7839

Footnotes

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Declaration of interest

This work was sponsored by Eli Lilly and Company.

Footnotes

References

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Oral olanzapine versus oral haloperidol in the maintenance treatment of schizophrenia and related psychoses

  • Pierre V. Tran (a1), Mary Anne Dellva (a1), Gary D. Tollefson (a1), Anita L. Wentley (a1) and Charles M. Beasley (a1)...
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