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Obstetric variables associated with bipolar affective puerperal psychosis

  • Emma Robertson Blackmore (a1), Ian Jones (a2), Monica Doshi (a3), Sayeed Haque (a4), Roger Holder (a5), Ian Brockington (a4) and Nick Craddock (a6)...

Abstract

Background

Previous cross-sectional studies have highlighted a number of obstetric variables that may be associated with the development of broadly defined puerperal (post-partum) psychosis. These include: (a) primiparity (b) pregnancy complications, (c) delivery complications, (d) Caesarean section, (e) female baby and (f) shorter gestation period.

Aims

To examine these risk factors in women with well-characterised bipolar affective puerperal psychosis.

Method

A sample of 129 women with bipolar affective puerperal psychosis were investigated using a design that takes advantage of within-subject comparisons of affected and unaffected deliveries.

Results

Two of the variables studied were independently associated with an episode of puerperal psychosis: primiparity (odds ratio=3.76, P<0.001) and delivery complications (odds ratio=2.68, P=0.022).

Conclusions

This study provides further evidence of the association between primiparity and puerperal psychosis and suggests that complications during delivery may be associated with a severe post-partum episode.

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Copyright

Corresponding author

Dr Ian Jones, Neuropsychiatric Genetics Unit, Department of Psychological Medicine, University of Cardiff, Heath Park, Cardiff CF144XN, UK. Tel: +44(029)2074 4663; fax: +44(029) 2074 6554; e-mail: jonesirl@cf.ac.uk

Footnotes

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Declaration of interest

None. Funding detailed in Acknowledgements.

Footnotes

References

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Obstetric variables associated with bipolar affective puerperal psychosis

  • Emma Robertson Blackmore (a1), Ian Jones (a2), Monica Doshi (a3), Sayeed Haque (a4), Roger Holder (a5), Ian Brockington (a4) and Nick Craddock (a6)...
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