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Neuropsychological performance in Lewy body dementia and Alzheimer's disease

  • Zuzana Walker (a1), Ruth L. Allen (a2), Sukhwinder Shergill (a3) and Cornelius L. E. Katona (a4)

Abstract

Background

Lewy body dementia (LBD) is emerging as a common cause of degenerative dementia. However, LBD cannot yet be diagnosed with certainty in life. There is some preliminary evidence that the pattern of cognitive impairment in LBD is different from that in Alzheimer's disease (AD). We set out to compare the performance on different subtests of the Cambridge Cognitive Examination (CAMCOG) of LBD patients and AD patients who were similar in overall degree of cognitive impairment.

Methods

All patients were recruited from a memory clinic LBD (n = 17) was diagnosed according to the McKeith clinical criteria. AD (n = 17) was diagnosed according to NINCDS-ADRDA criteria. The performances of LBD and AD patients on the neuropsychological subscales of the CAMCOG were compared by applying Hotelling's multivariate test of significance and subsequent univariate F tests.

Results

There were no statistically significant differences between the two groups on Mini-Mental State Examination and global CAMCOG rating. Hotelling's test with LBD and AD as the between-group factor and the neuropsychological subtests from CAMCOG as dependent variables revealed a statistically significant group effect (P < 0.05). Univariate F tests showed that recall (P < 0.02) and praxis (P < 0.003) significantly contributed to this effect.

Conclusions

These results suggest that there may be different neuropsychological profiles in the two conditions, with LBD subjects being better on recall but worse on praxis than those with AD.

Copyright

Corresponding author

Dr Zuzana Walker, Department of Psychiatry, University College London Medical School, Wolfson Building, Riding House Street, London WIN 8AA

References

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Neuropsychological performance in Lewy body dementia and Alzheimer's disease

  • Zuzana Walker (a1), Ruth L. Allen (a2), Sukhwinder Shergill (a3) and Cornelius L. E. Katona (a4)
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