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The Multifactorial Model of Disease Transmission: I. Description of the Model and its use in Psychiatry

Published online by Cambridge University Press:  29 January 2018

Theodore Reich ,
C. Robert Cloninger  and
Samuel B. Guze
Theodore Reich
Affiliation:
Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, St. Louis, Missouri 63110, U.S.A.
C. Robert Cloninger
Affiliation:
Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, St. Louis, Missouri 63110, U.S.A.
Samuel B. Guze
Affiliation:
Department of Psychiatry, Washington University School of Medicine, 4940 Audubon Avenue, St. Louis, Missouri 63110, U.S.A.
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Summary

The assumptions and properties of the Multifactorial Model of Disease Transmission are described, using the principles of quantitative genetics. No assumptions are made about the relative importance of genetic and environmental factors in the transmission of a disorder. The usefulness of the Model is discussed as a device for quantifying family data, discriminating between different modes of transmission and studying variations in disorders according to such clinical variables as age, sex, and severity of illness.

When only one form of a disorder can be distinguished, the degree to which the disorder is transmissible can be measured, and the relative importance of familial factors in the aetiology can be assessed. The assumptions which underlie the Model cannot be tested.

When two or more forms of a disorder can be distinguished, family and population data can be used to test the underlying assumptions of the Model. A good fit of the Model to the observed data indicates that the two subforms of the disorder represent different degrees of the same normally distributed process. This implies that the relative importance of transmissible and non-transmissible factors is the same in determining each subform of the disorder. The testability of the Multifactorial Model with multiple thresholds offers an opportunity for relating and understanding heterogeneous subforms of a disorder, for specifying the relationship between spectrum disorders, and for classifying psychiatric disorders.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 127 , Issue 1 , July 1975 , pp. 1 - 10
Copyright
Copyright © Royal College of Psychiatrists, 1975 

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References

1. Cavalli-Sforza, L. L. & Kidd, K. K. (1973) Genetic models for schizophrenia. Neuroscience Research Program Bulletin, 10(4), 406–19.Google Scholar
2. Cloninger, C. R., Reich, T. & Guze, S. (1975) The multifactorial model of disease transmission. II. Quantitative analysis of sex difference in the familial transmission of sociopathy (antisocial personality). British Journal of Psychiatry, 127, 11–22.Google Scholar
3. Crittenden, L. B. (1961) An interpretation of familial aggregation based on multiple genetic and environmental factors. Annals of the Mew York Academy of Sciences, 91, Art. 3, 769–80.Google Scholar
4. Curnow, R. (1972) The multifactorial model for the inheritance liability to disease and its implications for relatives at risk. Biometrics, 28, 931–46.CrossRefGoogle ScholarPubMed
5. Edwards, J. H. (1969) Familial predisposition in man. British Medical Bulletin, 25(1), 58–63.CrossRefGoogle ScholarPubMed
6. Falconer, D. S. (1965) The inheritance of liability to certain diseases. Annals of Human Genetics, 29, 51–76.Google Scholar
7. Goodwin, D., Schulsinger, F., Hermansen, L., Guze, S. & Winokur, G. (1973) Alcohol problems in adoptees raised apart from biological parents. Archives of General Psychiatry, 28, 238–43.Google Scholar
8. Gottesman, I. I. & Shields, J. (1973) Schizophrenia and Genetics. New York: Academic Press.Google Scholar
9. Heston, L. L. & Denney, D. (1968) Interaction between early life experience and biological factors in schizophrenia. Journal of Psychiatric Research, 6 (suppl.), 363–76.Google Scholar
10. Hutchinos, B. & Mednick, S. A. (1975) Registered criminality in the adoptive and biological parents of registered male criminal adoptees. In Genetics and Psychopatholog. (eds. Fieve, and Rosenthal, ). New York: Grune and Stratton (in press).Google Scholar
11. Kidd, K. K., Reich, T. & Kessler, S. (1973) The use of sex effect to discriminate between genetic models. Presented at the XIII International Congress of Genetics, Berkley, California.Google Scholar
12. Mendell, N. & Elston, R. C. (1971) Use of the tetrachoric correlation coefficient in the estimation of heritability of quasi-continuous traits. Biometrics, 27, 483 (abstract).Google Scholar
13. Reich, T., James, J. W. & Morris, C. A. (1972) The use of multiple thresholds in determining the mode of transmission of semi-continuous traits. Annals of Human Genetics, 36, 163–84.Google Scholar
14. Reich, T., Mullaney, J. & Winokup, C. (1975) The transmission of alcoholism. In Genetics and Psychopatholog. (eds. Fieve, and Rosenthal, ). New York: Grune and Stratton (in press).Google Scholar
15. Smith, C. (1970) Heritability of liability and concordance in monozygotic twins. Annals of Human Genetics, 34, 85–91.CrossRefGoogle Scholar
16. Smith, C., Falconer, D. S. & Duncan, L. J. P. (1972) A statistical and genetical study of diabetes. II. Heritability of liability. Annals of Human Genetics, 35, 281–99.CrossRefGoogle ScholarPubMed
17. Woolf, C. (1971) Congenital cleft lip. Journal of Medical Genetics, 8, 65–83.CrossRefGoogle ScholarPubMed
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