Frontostriatal and limbic dysfunction in late-life depression. Am J Geriatr Psychiatry
2002; 10: 687–95.
Sexton, CE, Mackay, CE, Ebmeier, KP.
A systematic review and meta-analysis of magnetic resonance imaging studies in late-life depression. Am J Geriatr Psychiatry
Sexton, CE, Mackay, CE, Ebmeier, KP.
A systematic review of diffusion tensor imaging studies in affective disorders. Biol Psychiatry
2009; 66: 814–23.
Sexton, CE, Allan, CL, Le Masurier, M, McDermott, LM, Kalu, UG, Herrmann, LL,
Magnetic resonance imaging in late-life depression: multi-modal examination of network disruption. Arch Gen Psychiatry
Shimony, JS, Sheline, YI, D'Angelo, G, Epstein, AA, Benzinger, TL, Mintun, MA,
Diffuse microstructural abnormalities of normal-appearing white matter in late life depression: a diffusion tensor imaging study. Biol Psychiatry
2009; 66: 245–52.
Pantel, J, Schroder, J, Essig, M, Popp, D, Dech, H, Knopp, MV,
Quantitative magnetic resonance imaging in geriatric depression and primary degenerative dementia. J Affect Disord
1997; 42: 69–83.
Taylor, WD, Steffens, DC, Payne, ME, MacFall, JR, Marchuk, DA, Svenson, IK,
Influence of serotonin transporter promoter region polymorphisms on hippocampal volumes in late-life depression. Arch Gen Psychiatry
2005; 62: 537–44.
Avila, R, Ribeiz, S, Duran, FL, Arrais, JP, Moscoso, MA, Bezerra, DM,
Effect of temporal lobe structure volume on memory in elderly depressed patients. Neurobiol Aging
2009; 32: 1857–67.
Alexopoulos, GS, Meyers, BS, Young, RC, Campbell, S, Silbersweig, D, Charlson, M.
‘Vascular depression’ hypothesis. Arch Gen Psychiatry
1997; 54: 915–22.
Herrmann, L, Lemasurier, M, Ebmeier, K.
White matter hyperintensities in late life depression: a systematic review. J Neurol Neurosurg Psychiatry
2008; 79: 619–24.
Chen, CS, Chen, CC, Kuo, YT, Chiang, IC, Ko, CH, Lin, HF.
Carotid intima-media thickness in late-onset major depressive disorder. Int J Geriatr Psychiatry
2006; 21: 36–42.
Smith, PJ, Blumenthal, JA, Babyak, MA, Doraiswamy, PM, Hinderliter, A, Hoffman, BM,
Intima-media thickness and age of first depressive episode. Biol Psychol
2009; 80: 361–4.
Thomas, AJ, O'Brien, JT, Davis, S, Ballard, C, Barber, R, Kalaria, RN,
Ischemic basis for deep white matter hyperintensities in major depression: a neuropathological study. Arch Gen Psychiatry
2002; 59: 785–92.
Thomas, AJ, Perry, R, Kalaria, RN, Oakley, A, McMeekin, W, O'Brien, JT.
Neuropathological evidence for ischemia in the white matter of the dorsolateral prefrontal cortex in late-life depression. Int J Geriatr Psychiatry
2003; 18: 7–13.
Bae, JN, MacFall, JR, Krishnan, KR, Payne, ME, Steffens, DC, Taylor, WD.
Dorsolateral prefrontal cortex and anterior cingulate cortex white matter alterations in late-life depression. Biol Psychiatry
2006; 60: 1356–63.
Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Arch Gen Psychiatry
2000; 57: 925–35.
Sapolsky, RM, Krey, LC, McEwen, BS.
The neuroendocrinology of stress and aging: the glucocorticoid cascade hypothesis. Endocr Rev
1986; 7: 284–301.
Bell-McGinty, S, Butters, MA, Meltzer, CC, Greer, PJ, Reynolds, CF, Becker, JT.
Brain morphometric abnormalities in geriatric depression: long-term neurobiological effects of illness duration. Am J Psychiatry
2002; 159: 1424–7.
Sheline, YI, Wang, PW, Gado, MH, Csernansky, JG, Vannier, MW.
Hippocampal atrophy in recurrent major depression. Proc Natl Acad Sci USA
1996; 93: 3908–13.
Andreescu, C, Butters, MA, Begley, A, Rajji, T, Wu, M, Meltzer, CC,
Gray matter changes in late life depression – a structural MRI analysis. Neuropsychopharmacology
2008; 33: 2566–72.
Janssen, J, Hulshoff Pol, HE, de Leeuw, FE, Schnack, HG, Lampe, IK, Kok, RM,
Hippocampal volume and subcortical white matter lesions in late life depression: comparison of early and late onset depression. J Neurol Neurosurg Psychiatry
2007; 78: 638–40.
O'Brien, JT, Lloyd, A, McKeith, I, Gholkar, A, Ferrier, N.
A longitudinal study of hippocampal volume, cortisol levels, and cognition in older depressed subjects. Am J Psychiatry
2004; 161: 2081–90.
Weber, K, Giannakopoulos, P, Delaloye, C, de Bilbao, F, Moy, G, Moussa, A,
Volumetric MRI changes, cognition and personality traits in old age depression. J Affect Disord
2010; 124: 275–82.
Ashtari, M, Greenwald, BS, Kramer-Ginsberg, E, Hu, J, Wu, H, Patel, M,
Hippocampal/amygdala volumes in geriatric depression. Psychol Med
1999; 29: 629–38.
Steffens, DC, Byrum, CE, McQuoid, DR, Greenberg, DL, Payne, ME, Blitchington, TF,
Hippocampal volume in geriatric depression. Biol Psychiatry
2000; 48: 301–9.
Butters, MA, Young, JB, Lopez, O, Aizenstein, HJ, Mulsant, BH, Reynolds, CF,
Pathways linking late-life depression to persistent cognitive impairment and dementia. Dialogues Clin Neurosci
2008; 10: 345–57.
Caraci, F, Copani, A, Nicoletti, F, Drago, F.
Depression and Alzheimer's disease: neurobiological links and common pharmacological targets. Eur J Pharmacol
2010; 626: 64–71.
Byers, AL, Yaffe, K.
Depression and risk of developing dementia. Nat Rev Neurol
2011; 7: 323–31.
American Psychiatric Association.
Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM-IV). , 1994.
D'Agostino, RB, Wolf, PA, Belanger, AJ, Kannel, WB.
Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study. Stroke
1994; 25: 40–3.
Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol
1967; 6: 278–96.
Yesavage, JA, Brink, TL, Rose, TL, Lum, O, Huang, V, Adey, M,
Development and validation of a geriatric depression screening scale: a preliminary report. J Psychiatr Res
1982; 17: 37–49.
Mioshi, E, Dawson, K, Mitchell, J, Arnold, R, Hodges, JR.
The Addenbrooke's Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening. Int J Geriatr Psychiatry
2006; 21: 1078–85.
Folstein, MF, Folstein, SE, McHugh, PR.
“Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res
1975; 12: 189–98.
Sahakian, BJ, Owen, AM, Morant, NJ, Eagger, SA, Boddington, S, Crayton, L,
Further analysis of the cognitive effects of tetrahydroaminoacridine (THA) in Alzheimer's disease: assessment of attentional and mnemonic function using CANTAB. Psychopharmacology (Berl)
1993; 110: 395–401.
Wechsler Adult Intelligence Scale. The Psychological Corporation, 1997.
McKenna, P, Warrington, EK.
Testing for nominal dysphasia. J Neurol Neurosurg Psychiatry
1980; 43: 781–8.
The Hopkins verbal learning test: development of a new memory test with six equivalent forms. Clin Neuropsychol
1991; 5: 125–42.
Le test de copie d'une figure complexe. Arch Psychol
1944; 30: 206–356.
Validity of the Trail Making Test as an indicator of organic brain damage. Percept Mot Skills
1958; 8: 271–6.
Sexton, CE, McDermott, L, Kalu, UG, Herrmann, LL, Bradley, KM, Allan, CL,
Exploring the pattern and neural correlates of neuropsychological impairment in late-life depression. Psychol Med
Lyness, JM, Pearson, JL, Lebowitz, BD, Kupfer, DJ.
Age at onset or late-life depression: a research agenda report of a MacArthur Foundation-NIMH Workshop. Am J Geriatr Psychiatry
1994; 2: 4–8.
Smith, SM, Jenkinson, M, Woolrich, MW, Beckmann, CF, Behrens, TE, Johansen-Berg, H,
Advances in functional and structural MR image analysis and implementation as FSL. Neuroimage
Fast robust automated brain extraction. Hum Brain Mapp
2002; 17: 143–55.
Patenaude, B, Smith, SM, Kennedy, DN, Jenkinson, M.
A Bayesian model of shape and appearance for subcortical brain segmentation. Neuroimage
2011; 56: 907–22.
Ashburner, J, Friston, KJ.
Voxel-based morphometry – the methods. Neuroimage
2000; 11: 805–21.
Good, CD, Johnsrude, IS, Ashburner, J, Henson, RNA, Friston, KJ, Frackowiak, RSJ.
A voxel-based morphometric study of ageing in 465 normal adult human brains. Neuroimage
2001; 14: 21–36.
Jenkinson, M, Bannister, P, Brady, M, Smith, S.
Improved optimization for the robust and accurate linear registration and motion correction of brain images. Neuroimage
2002; 17: 825–41.
Jenkinson, M, Smith, S.
A global optimisation method for robust affine registration of brain images. Med Image Anal
2001; 5: 143–56.
Rueckert, D, Sonoda, LI, Hayes, C, Hill, DL, Leach, MO, Hawkes, DJ.
Nonrigid registration using free-form deformations: application to breast MR images. IEEE Trans Med Imaging
1999; 18: 712–21.
Nichols, TE, Holmes, AP.
Nonparametric permutation tests for functional neuroimaging: a primer with examples. Hum Brain Mapp
2002; 15: 1–25.
Smith, SM, Nichols, TE.
Threshold-free cluster enhancement: addressing problems of smoothing, threshold dependence and localisation in cluster inference. Neuroimage
2009; 44: 83–98.
Smith, SM, Jenkinson, M, Johansen-Berg, H, Rueckert, D, Nichols, TE, Mackay, CE,
Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data. Neuroimage
2006; 31: 1487–505.
Mori, S, Wakana, S, Nagae-Poetscher, LM, van Zijl, PCM.
MRI Atlas of Human White Matter. Elsevier BV, 2005.
Thomas, AJ, Kalaria, RN, O'Brien, JT.
Depression and vascular disease: what is the relationship?
J Affect Disord
2004; 79: 81–95.
Paranthaman, R, Greenstein, AS, Burns, AS, Cruickshank, JK, Heagerty, AM, Jackson, A,
Vascular function in older adults with depressive disorder. Biol Psychiatry
2010; 68: 133–9.
Richardson, J, Kerr, SR, Shaw, F, Kenny, RA, O'Brien, JT, Thomas, AJ.
A study of orthostatic hypotension in late-life depression. Am J Geriatr Psychiatry
2009; 17: 996–9.
Vasudev, A, O'Brien, JT, Tan, MP, Parry, SW, Thomas, AJ.
A study of orthostatic hypotension, heart rate variability and baroreflex sensitivity in late-life depression. J Affect Disord
2011; 131: 374–8.
Gerritsen, L, Comijs, HC, van der Graaf, Y, Knoops, AJ, Penninx, BW, Geerlings, MI.
Depression, hypothalamic pituitary adrenal axis, and hippocampal and entorhinal cortex volumes – the SMART medea study. Biol Psychiatry
2011; 70: 373–80.
Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators. Eur J Pharmacol
2008; 583: 174–85.
Wang, Z, Neylan, TC, Mueller, SG, Lenoci, M, Truran, D, Marmar, CR,
Magnetic resonance imaging of hippocampal subfields in posttraumatic stress disorder. Arch Gen Psychiatry
2010; 67: 296–303.
Chen, MC, Hamilton, JP, Gotlib, IH.
Decreased hippocampal volume in healthy girls at risk of depression. Arch Gen Psychiatry
2010; 67: 270–6.
de Geus, EJ, van't Ent, D, Wolfensberger, SP, Heutink, P, Hoogendijk, WJ, Boomsma, DI,
Intrapair differences in hippocampal volume in monozygotic twins discordant for the risk for anxiety and depression. Biol Psychiatry
2007; 61: 1062–71.
Prusoff, BA, Merikangas, KR, Weissman, MM.
Lifetime prevalence and age of onset of psychiatric disorders: recall 4 years later. J Psychiatr Res
1988; 22: 107–17.
Wiener, P, Alexopoulos, GS, Kakuma, T, Meyers, BS, Rosenthal, E, Chester, J.
The limits of history-taking in geriatric depression. Am J Geriatr Psychiatry
1997; 5: 116–25.
Koolschijn, PCMP, van Haren, NEM, Lensvelt-Mulders, GJLM, Hulshoff Pol, HE, Kahn, RS.
Brain volume abnormalities in major depressive disorder: a meta-analysis of magnetic resonance imaging studies. Hum Brain Mapp
2009; 30: 3719–35.