Skip to main content Accessibility help
×
Home

Magnetic resonance imaging abnormalities in young euthymic patients with bipolar affective disorder

  • Selim M. El-Badri (a1), David A. Cousins (a1), Sean Parker (a1), Heather C. Ashton (a1), Victor L. McAllister (a2), I. Nicol Ferrier (a3) and P. Brian Moore (a3)...

Summary

Temporal lobe and limbic structures may be abnormal in bipolar disorder. T2-weighted magnetic resonance imaging (MRI) scans frequently show deep white matter lesions. MRI was performed on 50 young (19–39 years) euthymic patients with bipolar disorder and 26 controls. Mean temporal lobe volumes were reduced in patients (right, 9.42 cm3; left, 6.33 cm3) but this could not be ascribed to a specific structure. Deep white matter lesions were present in 5 patients but no controls raising questions of their aetiological significance.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Magnetic resonance imaging abnormalities in young euthymic patients with bipolar affective disorder
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Magnetic resonance imaging abnormalities in young euthymic patients with bipolar affective disorder
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Magnetic resonance imaging abnormalities in young euthymic patients with bipolar affective disorder
      Available formats
      ×

Copyright

Corresponding author

Dr P. B. Moore, Department of Psychiatry, University of Newcastle upon Tyne, Royal Victoria Infirmary, Queen Victoria Road, Newcastle upon Tyne NE1 4LP, UK. Email: P.B.Moore@ncl.ac.uk

Footnotes

Hide All

Declaration of interest

None. Support from Stanley Medical Research, Bethesda, MD, USA.

Footnotes

References

Hide All
Altshuler, L. L., Curran, J. G., Hauser, P., et al (1995) T2 hyperintensities in bipolar disorder: magnetic resonance comparison and literature meta-analysis. American Journal of Psychiatry, 152, 11391144.
Altshuler, L. L., Bartzokis, G., Grieder, T., et al (2000) An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biological Psychiatry, 48, 147162.
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM – IV). Washington, DC: APA.
Beck, A. T., Ward, C. H., Mendelson, M., et al (1961) An inventory for measuring depression. Archives of General Psychiatry, 4, 5657.
Dupont, R. M., Jernigan, T. L., Heindel, I. W., et al (1995) Magnetic resonance imaging and mood disorders. Localisation of white matter and other subcortical abnormalities. Archives of General Psychiatry, 52, 747755.
Fazekas, F., Kleinert, R., Offenbacher, H., et al (1993) Pathologic correlates of incidental MRI white matter signal intensities. Neurology, 43, 10831089.
Harrison, P. J. (2002) The neuropathology of primary mood disorders. Brain, 125, 12481449.
Harvey, I., Persaud, R., Ron, M. A., et al (1994) Volumetric MRI measurements in bipolars compared with schizophrenics and healthy controls. Psychological Medicine, 24, 689699.
Hauser, P., Matochik, J., Altshuler, L. L., et al (2000) MRI-based measurements of temporal lobe and ventricular structures in patients with bipolar I and bipolar II disorders. Journal of Affective Disorders, 60, 2532.
Lim, K. O., Rosenbloom, M. J., Faustman, W. O., et al (1999) Cortical gray matter deficit in patients with bipolar disorder. Schizophrenia Research, 40, 219227.
Moore, P. B., Shepherd, D. J., Eccleston, D., et al (2001a) Cerebral white matter lesions in bipolar affective disorder: relationship to outcome. British Journal of Psychiatry, 178, 172176.
Moore, P. B., El-Badri, S. M., Cousins, D., et al (2001b) White matter lesions and season of birth of patients with bipolar affective disorder. American Journal of Psychiatry, 158, 15211524.
Nelson, H. E. (1982) National Adult Reading Test (NART). Windsor: NFER-Nelson.
Soares, J. G. & Mann, J. M. (1997) The anatomy of mood disorders – review of structural neuroimaging studies. Biological Psychiatry, 41, 86106.
Strakowski, S. M., Wilson, D. R., Tohen, M., et al (1993) Structural brain abnormalities in first-episode mania. Biological Psychiatry, 33, 602609.
Swayze, V. W., Andreasen, N. C., Alliger, R. J., et al (1992) Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study. Biological Psychiatry, 31, 221240.

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Magnetic resonance imaging abnormalities in young euthymic patients with bipolar affective disorder

  • Selim M. El-Badri (a1), David A. Cousins (a1), Sean Parker (a1), Heather C. Ashton (a1), Victor L. McAllister (a2), I. Nicol Ferrier (a3) and P. Brian Moore (a3)...
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *