Skip to main content Accessibility help
×
Home

Islington study of dementia subtypes in the community

  • Tim Stevens (a1), Gill Livingston (a1), Ginnette Kitchen (a2), Monica Manela (a1), Zuzana Walker (a1) and Cornelius Katona (a1)...

Abstract

Background

Epidemiological studies of dementia subtypes have revealed widely varying distribution rates. There are almost no published community prevalence data for dementia with Lewy bodies (DLB) or the frontal lobe dementias (FLD).

Aims

To identify the distribution of dementia subtypes in a representative community population of older people.

Method

People aged ⩾65 years in randomised enumeration districts in Islington, north London, were screened using a reliable and valid questionnaire. People screened as having dementia were assessed in detail and diagnoses were made according to standard diagnostic criteria.

Results

Of 1085 people interviewed, 107 (9.86%) met screening criteria for dementia. Diagnoses were made for 72 people (67.3%). Distribution of subtypes varied according to the criteria used; the best-validated criteria yielding: Alzheimer's disease 31.3%; vascular dementia 21.9%; DLB 10.9%; and FLD 7.8%.

Conclusions

Alzheimer's disease is confirmed as the most common cause of dementia in older people, followed by vascular dementia. However, DLB and FLD occur sufficiently often to be seen frequently in clinical practice and should be incorporated into future editions of standard diagnostic criteria.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Islington study of dementia subtypes in the community
      Available formats
      ×

      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Islington study of dementia subtypes in the community
      Available formats
      ×

      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Islington study of dementia subtypes in the community
      Available formats
      ×

Copyright

Corresponding author

Tim Stevens, Department of Psychiatry and Behavioural Sciences, Royal Free and University College Medical School, 2nd Floor, Wolfson Building, Riding House Street, London WIN 8AA, UK. Tel: 020 7288 5931; Fax: 020 7530 2304; e-mail: tim.stevens@ucl.ac.uk

Footnotes

Hide All

Declaration of interest

None.

Footnotes

References

Hide All
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM–IV). Washington, DC: APA.
Borkowski, J. G., Benton, A. L. & Spreen, O. (1967) Word fluency and brain damage. Neuropsychology, 5, 135140.
Brun, A. (1987) Frontal lobe degeneration of non-Alzheimer's type I. Neuropathology. Archives of Gerontology and Geriatrics, 6, 209233.
Brun, A., England, B., Gustafson, L., et al (1994) Consensus statement. Clinical and neuropathological criteria for frontotemporal dementia. Lund and Manchester groups. Journal of Neurology, Neurosurgery and Psychiatry, 57, 416418.
Copeland, J. R. M., Kelleher, M. J., Kellet, J. M., et al (1976) A semi-structured clinical interview for the assessment and diagnosis of mental state in the elderly: the Geriatric Mental State Schedule I. Psychological Medicine, 16, 8999.
Erkinjuntti, T., Ostbye, T., Steenhuis, R., et al (1997) The effect of different diagnostic criteria on the prevalence of dementia. New England Journal of Medicine, 337, 16671774.
Folstein, M. F., Folstein, S. E. & McHugh, P. R. (1975) ‘Mini-Mental State’: a practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189198.
Forno, L. S. & Langston, J. W. (1988) The amygdala–parahippocampal region: a predilection site for Lewy bodies. Journal of Neuropathology and Experimental Neurology, 47, 354.
Galasko, D., Hansen, L. A., Katzman, R., et al (1994) Clinical — neuropathological correlations in Alzheimer's disease and related dementias. Archives of Neurology, 51, 888895.
Gold, G., Giannakopoulos, P., Montes-Paixo-Junior, C., et al (1997) Sensitivity and specificity of newly proposed clinical criteria for possible vascular dementia. Neurology, 49, 690694.
Gregory, C. A. & Hodges, J. R. (1993) Dementia of frontal type and the focal lobar atrophies. International Review of Psychiatry, 5, 397406.
Gregory, C. A. & Hodges, J. R. (1996) Dementia of frontal type: use of consensus criteria and prevalence of psychiatric features. Neuropsychiatry, Neuropsychology and Behavioural Neurology, 9, 145153.
Gregory, C. A., Orrell, M., Sahakian, B., et al (1997) Can frontotemporal dementia and Alzheimer's disease be differentiated using a brief battery of tests? International Journal of Geriatric Psychiatry, 12, 375383.
Gregory, C. A., McKenna, P. J. & Hodges, J. R. (1998) Dementia of frontal type and simple schizophrenia: two sides of the same coin? Neurocase, 4, 16.
Gurland, B., Golden, R. R., Teresi, J. A., et al (1984) The Short-CARE: an efficient instrument for the assessment of depression, dementia and disability. Journal of Gerontology, 39, 166169.
Hachinski, V. C., Ilif, L. D., Zilcha, I. E., et al (1975) Cerebral blood flow in dementia. Archives of Neurology, 32, 632637.
Hohl, U., Tiraboschi, P., Hansen, L. A., et al (2000) Diagnostic accuracy of dementia with Lewy bodies. Archives of Neurology, 57, 347351.
Jarman, B. (1983) Identification of underprivileged areas. BMJ, 286, 17051709.
Jorm, A. F., Korten, A. E. & Henderson, A. S. (1987) The prevalence of dementia: a quantitative integration of the literature. Acta Psychiathca Scandinavica, 76, 465479.
Lim, A., Tsuang, D., Kukull, W., et al (1999) Clinico-neuropathological correlation of Alzheimer's disease in a community-based case series. Journal of the American Geriatric Society, 47, 564569.
Lobo, A., Launer, L. J., Fratiglioni, L., et al (2000) Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology, 54 (suppl. 5), s4s9.
McKeith, I. G., Galasko, D., Wilcock, G. K., et al (1995) Lewy body dementia – diagnosis and treatment. British Journal of Psychiatry, 167, 709717.
McKeith, I. G., Ballard, C. G., Perry, R. H., et al (2000) Prospective validation of consensus criteria for the diagnosis of dementia with Lewy bodies. Neurology, 54, 10501058.
McKhann, G., Drachman, D., Folstein, M., et al (1984) Clinical diagnosis of Alzheimer's disease: report of the NINCDS–ADRDA Work Group under the auspices of the Department of Health and Human Services Task Force on Alzheimer's disease. Neurology, 34, 939944
Neary, D., Snowden, J. S., Gustafson, L., et al (1998) Frontotemporal lobar degeneration. A consensus on clinical diagnostic criteria. Neurology, 51, 15461554.
Oliva, R. (2000) Genetica de lademencia frontotemporaly alteraciones ce gen tau. Neurologia, 15 (suppl. 1), 3337.
Reitan, R. M. (1958) Validity of the trail making test as an indicator of organic brain damage. Perceptual and Motor Skills, 8, 271276.
Roman, G. C., Tabemichi, T. K., Erkinjuntii, T., et al (1993) Vascular dementia: diagnostic criteria for research studies. Report of the NINDS–AIREN international workshop. Neurology, 43, 250260.
Shallice, T. & Evans, M. E. (1978) The involvement of the frontal lobes in cognitive estimation. Cortex, 14, 294303.
Stern, M. B. (1988) The clinical characteristics of Parkinson's disease and parkinsonian syndromes: diagnosis and assessment. In The Comprehensive Management of Parkinsons Disease (eds Stern, M. B. & Hurtig, H. I.), pp. 350. New York: PMA Publishing Corporation.
World Health Organization (1992) Tenth Revision of the International Classification of Diseases and Related Health Problems (ICD–10). Geneva: WHO.
Yamada, T., Hattori, H., Miura, A., et al (2001) Prevalence of Alzheimer's disease, vascular demertia and dementia with Lewy bodies in a Japanese population. Psychiatry and Clinical Neurosciences, 55, 2125.

Islington study of dementia subtypes in the community

  • Tim Stevens (a1), Gill Livingston (a1), Ginnette Kitchen (a2), Monica Manela (a1), Zuzana Walker (a1) and Cornelius Katona (a1)...

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Islington study of dementia subtypes in the community

  • Tim Stevens (a1), Gill Livingston (a1), Ginnette Kitchen (a2), Monica Manela (a1), Zuzana Walker (a1) and Cornelius Katona (a1)...
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *