Skip to main content Accessibility help
×
Home

The Impact of Molecular Genetics on Our Understanding of the Psychoses

  • Michael J. Mullan (a1) and Robin M. Murray (a2)

Abstract

Studies demonstrating the linkage to separate chromosomal locations of Alzheimer's disease, manic depression, and schizophrenia require re-evaluation of our ideas of their genetic aetiology. This article reviews the findings, and explores the increasing contribution of the ‘new genetics' to our understanding of the organic and functional psychoses.

Copyright

Corresponding author

Correspondence

References

Hide All
Baron, M., Risch, N., Hamburger, R., et al (1987) Genetic linkage between X-chromosome markers and bipolar affective illness. Nature, 326, 289292.
Baron, M. & Rainer, J. D. (1988) Molecular genetics and human disease. British Journal of Psychiatry, 152, 741753.
Basset, A., McGillivray, B., Jones, B., et al (1988) Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet, i, 799801.
Bock, G. & Collins, G. M. (1987) Molecular Approaches to Human Polygenic Disease. Ciba Foundation Symposium No. 130. Chichester: John Wiley.
Crow, T. J. (1986) The continuum of psychosis and its implication for the structure of the gene. British Journal of Psychiatry, 149, 419429.
Davies, K. E. (1986) Human Genetic Diseases. Oxford: IRL Press.
Davis, C. G. (1987) The LDL receptor. In Molecular Approaches to Human Polygenic Disease (eds Bock, G. & Collins, G. M.). Chichester: John Wiley.
DeLisi, L., Detera-Wadleigh, S., Goldin, L., et al (1988) Abstracts of the Biennial Winter Workshop in Schizophrenia. Badgastein, Austria. Schizophrenia Research, 1.
Detera-Wadleigh, S., Berrettini, W., Goldin, L., et al (1987) Close linkage of c-Harvey-ras-1 and the insulin gene to affective disorder is ruled out in three North American pedigrees. Nature, 325, 806808.
Egeland, J., Gerhard, D., Pauls, D., et al (1987) Bipolar affective disorders linked to DNA markers on chromosome 11. Nature, 325, 783787.
Gershon, E., Hamovit, J., Guroff, J., et al (1982) A family study of schizoaffective, bipolar I, bipolar II, unipolar, and normal control probands. Archives of General Psychiatry, 39, 11571167.
Gill, M., McKeon, P. & Humphries, P. (1988) Linkage analysis of manic-depression in an Irish family using H-ras 1 and INS DNA markers. Journal of Medical Genetics, 25, 634635.
Gottesman, I. & Shields, J. (1972) Schizophrenia and Genetics: A Twin Study Vantage Point. Orlando: Academic Press.
Gurling, H. M. D. (1985) Application of molecular biology to mental illness. Psychiatric Developments, 3, 257273.
Gusella, J., Wexler, N., Conneally, M. P., et al (1983) A polymorphic DNA marker genetically linked to Huntington's disease. Nature, 306, 234238.
Karlsson, J. (1988) Partly dominant transmission of schizophrenia in Iceland. British Journal of Psychiatry, 152, 324329.
Kendler, K. S. (1987) The feasibility of linkage studies in schizophrenia. In Biological perspectives of Schizophrenia (eds Helmchen, H. & Henn, F. A.). Chichester: John Wiley.
Kennedy, J. L., Guiffra, L. A., Moises, H. W. et al (1988) Evidence against linkage of schizophrenia to markers on chromosome 5. Nature, 336, 167169.
Hodgkinson, S., Sherrington, R., Gurling, H., et al (1987) Molecular genetic evidence for the heterogeneity in manic depression. Nature, 325, 805806.
Mendlewicz, J., Linkowski, P. & Milmotte, J. (1980) Linkage between glucose-6-phosphate dehydrogenase deficiency and manic depressive psychosis. British Journal of Psychiatry, 137, 337342.
Mendlewicz, J., Simon, P., Sevy, S., et al (1987) Polymorphic DNA marker on X chromosome and manic depression. Lancet, i, 12301232.
Mons, R., Breitner, J., Silverman, J., et al (1987) Alzheimer's disease; morbid risk among first-degree relatives approximates 50% by 90 years of age. Archives of General Psychiatry, 44, 405408.
Neary, D., Snowden, J., Northern, B., et al (1988) Dementia of frontal lobe type. Journal of Neurology, Neurosurgery and Psychiatry, 51, 353361.
Oliver, C. & Holland, A. (1986) Down's syndrome and Alzheimer's disease: a review. Psychological Medicine, 16, 307322.
O'Rourke, D. H., Gottesman, I. I., Suarez, B. K., et al (1982) Refutation of the single locus model in the aetiology of schizophrenia. American Journal of Human Genetics, 33, 630649.
Reich, T., Clayton, P. & Winokur, G. (1969) Family history studies; V. The genetics of mania. American Journal of Psychiatry, 125, 13581359.
Schellenberg, G. D., Bird, T. D., Wijsman, E. M. et al (1988) Absence of linkage of chromosome 21q21 markers to familial Alzheimer's disease. Science, 241, 15071510.
Scott, J. (1987) Molecular genetics of common diseases. British Medical Journal, 295, 769771.
Sherrington, , et al (1988) Localisation of a susceptibility locus for schizophrenia on chromosome 5. Nature, 336, 164167.
St George-Hyslop, P., Tanzi, R., Polinsky, R., et al (1987) The genetic defect causing familial Alzheimer's disease maps on chromosome 21. Science, 235, 885889.
Sturt, E. & McGuffin, P. (1985) Can linkage and association resolve the genetic aetiology of psychiatric disorders? Review and argument. Psychological Medicine, 15, 455462.
Weatherall, D. J. (1985) The ‘new genetics’ and clinical practice. British Medical Journal, 295, 587588.
Weatherall, D. J. (1987) Molecular and cell biology in clinical medicine. British Medical Journal, 295, 587588.
Whatley, S. A., Owen, M. J. & Murray, R. M. (1988) Neuropsychiatry disorders and the new genetics. In The Bridge Between Neurology and Psychiatry (eds Trimble, M. & Reynolds, E.). London: Churchill Livingstone.
Van Broeckhoven, C., Genthe, A., Vandenberge, A., et al (1987) Failure of familial Alzheimer's disease to segregate with the A4-amyloid gene in several European families. Nature, 329, 153155.
Wasmuth, J., Hewitt, J., Smith, B., et al (1988) A highly polymorphic locus very tightly linked to the Huntington's disease gene. Nature, 332, 734736.

Related content

Powered by UNSILO

The Impact of Molecular Genetics on Our Understanding of the Psychoses

  • Michael J. Mullan (a1) and Robin M. Murray (a2)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.

The Impact of Molecular Genetics on Our Understanding of the Psychoses

  • Michael J. Mullan (a1) and Robin M. Murray (a2)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *