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Identical Twins Concordant for the Progression of Affective Illness to Schizophrenia

Published online by Cambridge University Press:  29 January 2018

Kenneth S. Kendler
Affiliation:
Department of Psychiatry and Schizophrenia Biological Research Center, Bronx V.A. Medical Center, Mt. Sinai School of Medicine, Bronx, New York, USA
Ming T. Tsuang
Affiliation:
Section of Psychiatry and Human Behavior, Brown University; Associate Medical Director and Director, Psychiatric Epidemiology Research Unit Butler, Hospital, 345 Blackstone Blvd., Providence, Rhode Island, 02906, USA

Summary

A pair of identical twins for whom long-term follow-up information was available progressed concordantly from typical ‘affective illness' to process schizophrenia. We discuss a possible genetic basis for a certain form of schizophrenia which may present typical affective features in the initial phase of process schizophrenia.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1982 

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References

Astrup, C., Fossum, A. & Holmboe, R. (1962) Prognosis in Functional Psychoses: Clinical, Social and Genetic Aspects. Springfield, Illinois: Thomas.Google Scholar
Foulds, G. A. & Bedford, A. (1975) Hierarchy of classes of personal illness. Psychological Medicine, 5, 181–92.Google Scholar
Kendler, K. S., Gruenberg, A. M. & Strauss, J. S. (1982) An independent analysis of the Copenhagen sample of the Danish adoption study of schizophrenia. IV: The relationship between major depressive disorder and schizophrenia. Archives of General Psychiatry, 39, 639–42.Google Scholar
Kraepelin, E. (1919) Dementia Praecox and Paraphrenia (translated by Barclay, R. M.). Edinburgh: E. and S. Livingstone.Google Scholar
Lewis, N. D. C. & Hubbard, I. D. (1931) Mechanisms and prognostic aspects of the manic-depressive-schizophrenic combinations. Research Publications—Association for Research in Nervous and Mental Disease, 11, 539608.Google Scholar
Lewis, N. D. C. & Piotrowski, Z. A. (1954) Clinical diagnosis of manic-depressive psychosis. In Depression, pp 2538, (eds. Hoch, P. and Zubin, J.). New York: Grune and Stratton.Google Scholar
McGuffin, P., Reveley, A. & Holland, A. (1982) Identical triplets: Non-identical psychosis? British Journal of Psychiatry, 140, 16.Google Scholar
Ollerenshaw, D. P. (1973) The classification of the functional psychoses. British Journal of Psychiatry, 122, 517–30.Google Scholar
Pope, H. G. & Lipinski, J. F. (1978) Diagnosis in schizophrenia and manic-depressive illness: A reassessment of the specificity of ‘schizophrenic’ symptoms in the light of current research. Archives of General Psychiatry, 35, 811–28.CrossRefGoogle Scholar
Slater, E. (1947) Genetical causes of schizophrenic symptoms. Monatsschrift fur psychiatric und neurologie, 113, 50–8.Google Scholar
Slater, E. (1953) Psychotic and Neurotic Illnesses in Twins. London: Her Majesty's Stationery Office.Google Scholar
Surtees, P. G. & Kendell, R. E. (1979) The hierarchy model of psychiatric symptomatology: An investigation based on present state examination ratings. British Journal of Psychiatry, 135, 438–43.Google Scholar
Tsuang, M. T. (1965) A study of pairs of sibs both hospitalized for mental disorder. (Ph.D thesis) University of London.Google Scholar
Tsuang, M. T. Winokur, G. & Crowe, R. R. (1980) Morbidity risks of schizophrenia and affective disorders among first degree relatives of patients with schizophrenia, mania, depression and surgical conditions. British Journal of Psychiatry, 137, 497504.Google Scholar
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