Skip to main content Accessibility help
×
Home

Hillside study of risk and early detection in schizophrenia

  • Barbara Cornblatt (a1), Michael Obuchowski (a1), David Schnur (a2) and John D. O'Brien (a2)

Abstract

Background The Hillside Study of Risk and Early Detection in Schizophrenia is a prospective study of young probands (ages 14–28) and their at-risk siblings (ages 14–24). A major goal is the identification of early predictors of illness that will facilitate intervention. The project design and pilot study are discussed.

Method Fifteen adolescents were compared to 14 typical age-of-onset adults, all undergoing their first hospitalisation for schizophrenia.

Results There were no differences between adolescents and adults on any of the measures administered (i.e. attention, eye tracking, neurocognitive or clinical). In addition, for the sample overall, no association was found between neurocognitive functions and clinical state, either at admission or after treatment.

Conclusions Individuals with adolescent onset of schizophrenia are considered to be representative of schizophrenia in general. Furthermore, neurocognitive deficits and clinical symptoms are concluded to be two independent classess of risk indicators.

Copyright

Corresponding author

Correspondence: Barbara Cornblatt, Hillside Hospital, Long Island Jewish Medical Center, 75–59 263rd Street, Glen Oaks, NY 11004, USA

References

Hide All
Abel, L. A. & Ziegler, A. S. (1988) Smooth pursuit eye movements in people with schizophrenia – what constitutes quantitative assessments? Biological Psychiatry, 24, 747762.
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.
Andreasen, N. C. (1983) Comprehensive Assessment of Symptoms and History: CASH. Iowa City, IA: University of Iowa College of Medicine.
Bilder, R. M., Lipshutz-Broch, L., Reiter, G., et al (1992) Intellectual deficits in first-episode schizophrenia: evidence for progressive deterioration. Schizophrenia bulletin, 18, 437438.
Cornblatt, B., Risch, N., Faris, G., et al (1988) The Continuous Performance Test, Identical Pairs Version (CPT-IP): I. New findings about sustained attention in normal families. Psychiatry Research, 26, 223238.
Cornblatt, B., Lenzenweger, M. & Erlenmeyer-Kimling, L. (1989) The Continuous Performance–Identical Pairs (CPT–IP): II. contrasting profiles of attentional deficits in schizophrenic and depressed patients. Psychiatry Research, 29, 6585.
Cornblatt, B., Lenzenweger, M., Dworkin, R. H., et al (1992) Childhood attentional dysfunctions predict social deficits in unaffected adults at risk for schizophrenia. British Journal of Psychiatry, 161, 5964.
Cornblatt, B. & Kelip, J. (1994) Impaired attention, genetics, and the pathophysiology of schizophrenia. Schizophrenia Bulletin, 20, 3146.
Cornblatt, B., Dworkin, R. H., Wolf, I. E., et al (1996) Markers, developmental processes and schizophrenia. In Frontiers in Developmental Psychopathology (eds Lenzenweger, M. & Haugaard, J.), pp. 125147. New York: Oxford University Press.
Delisi, L. E. (1992) The significance of age of onset for schizophrenia. Schizophrenia Bulletin, 18, 209216.
Eaton, W. W., Mortensen, P. B., Hermann, H., et al (1992a) Long-term course of hospitalisation for schizophrenia: part I, risk for rehospitalisation. Schizophrenia Bulletin, 18, 217228.
Eaton, W. W., Bilker, W., Haro, J., et al (1992b) Long-term course of hospitalisation for schizophrenia: part II, change with passage of time. Schizophrenia Bulletin, 18, 229242.
Erlenmeyer-Kimling, L. & Cornblatt, B. (1987) High-risk research in schizophrenia: a summary of what has been learned. Journal of Psychiatric Research, 21, 401411.
Erlenmeyer-Kimling, L., Cornblatt, B., Fleiss, J., et al (1984a) Interim report on prospective study of children at risk for schizophrenia. In Handbook of Longitudinal Research, Vol. 2 (eds Mednick, S. A. & Harway, M.), pp. 487503. New York: Praeger.
Erlenmeyer-Kimling, L., Marcuse, Y., Cornblatt, B., et al (1984b) The New York high risk project. In Children at Risk for Schizophrenia (eds Watt, N. F., Anthony, E.J., Wynne, L.C., et al), pp. 169189. New York: Cambridge University Press.
Falloon, I. R. (1992) Early intervention for first episodes of schizophrenia: a preliminary exploration. Psychiatry, 55, 415.
Falloon, I. R. H., Kydd, R. R., Coverdale, J. H., et al (1996) Early detection and intervention for initial episodes of schizophrenia. Schizophrenia Bulletin, 22, 271282.
Fish, B., Marcus, J., Hans, S. L., et al (1992) Infants at risk for schizophrenia: sequelae of a genetic neurointegrative defect. Archives of General Psychiatry, 49, 221235.
Gottesman, I. I. (1991) Schizophrenia Genesis: The Origins of Madness. New York: W. H. Freeman and Company.
Gottesman, I. I., Shields, J. & Hanson, D. (1982) Schizophrenia: The Epigenetic Puzzle. New York: Cambridge, University Press.
Haas, G. L. & Sweeney, J. A. (1992) Premorbid and onset features of first-episode schizophrenia. Schizophrenia Bulletin, 18, 373386.
Heaton, R. K. (1981) Wisconsin Card Sorting Test Manual. Odessa, FL: Psychological Assessment Resources.
lacono, W. G. & Beiser, M. (1992) Where are the women in first-episode studies of schizophrenia? Schizophrenia Bulletin, 18, 471480.
Inoue, K., Nakajima, T. & Kato, N. (1986) A longitudinal study of schizophrenia in adolescence: I. the one- to three-year outcome. Japanese Journal of Psychiatry and Neurology, 40, 143151.
Kay, S. R., Opler, L. A. & Lindenmayer, J. P. (1989) The positive and negative syndrome scale (PANSS): rationale and standardisation. British Journal of Psychiatry, 155 (suppl. 7), 5967.
Keshavan, M. S. & Schooler, N. R. (1992) First-episode studies in schizophrenia: criteria and characterisation. Schizophrenia Bulletin, 18, 491514.
Kirch, D. G., Keith, S. J. & Matthews, S. M. (1992) Research on first-episode psychosis: report on a National Institute of Mental Health workshop. Schizophrenia Bulletin, 18, 179184.
Larsen, T. K., McGlashan, T. H. & Moe, L. C. (1996) First-episode schizophrenia: I early course parameters. Schizophrenia Bulletin, 22, 241256.
Lezak, M. D. (1995) Neuropsychological Assessment, (3rd edn). New York: Oxford University Press.
Loebel, A. D., Lieberman, J. A., Alvir, J. M. J., et al (1992) Duration of psychosis and outcome in first-episode schizophrenia. American Journal of Psychiatry, 149, 11831188.
Marcus, J., Hans, S. L., Nagler, S., et al (1987) Review of the NIMH Israeli Kibbutz-City Study and the Jerusalem Infant Development Study. Schizophrenia Bulletin, 13, 425438.
McGlashan, T. H. (1996) Early detection and intervention in schizophrenia: research. Schizophrenia Bulletin, 22, 327346.
McGlashan, T. H. & Johannessen, J. O. (1996) Early detection and intervention with schizophrenia: rationale. Schizophrenia Bulletin, 22, 201222.
McGorry, P. D., Edwards, J., Mihalopoulos, C., et al (1996) EPPIC: an evolving system of early detection and optimal management. Schizophrenia Bulletin, 22, 305326.
Mednick, S. A., Mura, E., Schulsinger, F., et al (1971) Perinatal conditions and infant development in children with schizophrenic parents. Social Biology, 18 (suppl.), S102–113.
Mednick, S. A., Parnas, J. & Schulsinger, F. (1987) The Copenhagen High-Risk Project, 1962–1986. Schizophrenia Bulletin, 13, 485495.
Nuechterlein, K. H. (1983) Signal detection in vigilance tasks and behavioural attributes among offspring of schizophrenic mothers and among hyperactive children. journal of Abnormal Psychology, 92, 428.
Orvaschel, H. & Puig-Antich, J. (1987) Schedule for Affective Disorder and Schizophrenia for School Age Children, Epidemiologic Version. Philadelphia, PA: Medical College of Pennsylvania.
Overall, J. E. & Gorham, D. R. (1962) The Brief Psychiatric Rating Scale. Psychological Reports, 10, 799812.
Ram, R., Bromet, E. J., Eaton, W. W., et al (1992) The natural course of schizophrenia: a review of first-admission studies. Schizophrenia Bulletin, 18, 185208.
Reitan, R. M. & Wolfson, D. (1985) The Halstead-Reitan Neuropsychological Test Battery. Tucson: Neuropsychology Press.
Schellenburg, G. D., Pericak, M. A., Wiijsman, E. M., et al (1991) Linkage analysis of familial Alzheimer disease, using chromosome 21 markers. American Journal of Human Genetics, 48, 563583.
SPSS Inc. (1993) Statistical Package for the Social Sciences, Release 6.0.1. Chicago, IL: SPSS Inc.
Spurr, N. K., Kelsell, D. P., Black, D., et al (1993) Linkage analysis of early-onset breast and ovarian cancer families, with markers on the long arm of chromosome 17. American Journal of Human Genetics, 52, 777785.
Tienari, P., Wynne, L. C., Moring, J., et al (1994) The Finnish Adoptive Family Study of Schizophrenia: implications for family research. British Journal of Psychiatry, 164 (suppl. 23), 2026.
Vaglum, P. (1996) Earlier detection and intervention in schizophrenia: unsolved questions. Schizophrenia Bulletin, 22, 347352.
Wyatt, R. J. (1991) Neuroleptics and the natural course of schizophrenia. Schizophrenia Bulletin, 17, 325351.
Yung, A. R. & McGorry, P. D. (1996) The prodromal phase of first-episode psychosis: past and current conceptualisations. Schizophrenia Bulletin, 22, 353370.
Yung, A. R. & McGorry, P. D., McFarlane, C. A., et al (1996) Monitoring and care of young people at incipient risk of psychosis. Schizophrenia Bulletin, 22, 283304.
Zimmermann, W. W., Bender, E., Rohde, K., et al (1993) Linkage analysis in German breast cancer families with early-onset of the disease, using highly polymorphic markers from the chromosome 17 Q11–Q24 region. American Journal of Human Genetics, 52, 789791.

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Hillside study of risk and early detection in schizophrenia

  • Barbara Cornblatt (a1), Michael Obuchowski (a1), David Schnur (a2) and John D. O'Brien (a2)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *