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Grey matter correlates of syndromes in schizophrenia: A semi-automated analysis of structural magnetic resonance images

  • S. E. Chua (a1), I. C. Wright (a2), J.-B. Poline (a3), P. F. Liddle (a4), R. M. Murray (a2), R. S. J. Frackowiak (a3), K. J. Friston (a3) and P. K. McGuire (a2)...

Abstract

Background

Symptoms in schizophrenia duster into syndromes, each of which may be associated with a particular pattern of cerebral blood flow. We sought to investigate whether these syndromes are also related to neuroanatomical changes.

Method

A semi-automated method was used to examine structural magnetic resonance images in 12 patients with schizophrenia. The relationship between the relative regional grey matter volume and ratings of the syndromes of psychomotor poverty, disorganisation and reality distortion was investigated.

Results

There was a significant negative correlation between psychomotor poverty score and the relative volume of the left ventro-medial prefrontal grey matter, and a significant positive correlation between disorganisation and the relative volumes of the hippocampus, and the parahippocampal/fusiform gyrus bilaterally.

Conclusion

The correlation between psychomotor poverty and left prefrontal grey matter volume resembles that previously seen with prefrontal blood flow in the same patients, suggesting that this functional abnormality is related to an underlying anatomical change.

Copyright

Corresponding author

Dr S. E. Chua, Department of Psychiatry, Queen Mary Hospital, Pokfulam Road, Hong Kong

References

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Grey matter correlates of syndromes in schizophrenia: A semi-automated analysis of structural magnetic resonance images

  • S. E. Chua (a1), I. C. Wright (a2), J.-B. Poline (a3), P. F. Liddle (a4), R. M. Murray (a2), R. S. J. Frackowiak (a3), K. J. Friston (a3) and P. K. McGuire (a2)...

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Grey matter correlates of syndromes in schizophrenia: A semi-automated analysis of structural magnetic resonance images

  • S. E. Chua (a1), I. C. Wright (a2), J.-B. Poline (a3), P. F. Liddle (a4), R. M. Murray (a2), R. S. J. Frackowiak (a3), K. J. Friston (a3) and P. K. McGuire (a2)...
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