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Grey matter correlates of minor physical anomalies in the ÆSOP first-episode psychosis study

  • K. Dean (a1), P. Fearon (a1), K. Morgan (a1), G. Hutchinson (a2), K. Orr (a3), X. Chitnis (a4), J. Suckling (a5), R. Mallet (a6), J. Leff (a6), P. B. Jones (a5), R. M. Murray (a1) and P. Dazzan (a1)...

Abstract

Background

Minor physical anomalies are more prevalent among people with psychosis. This supports a neurodevelopmental aetiology for psychotic disorders, since these anomalies and the brain are both ectodermally derived. However, little is understood about the brain regions implicated in this association.

Aims

To examine the relationship between minor physical anomalies and grey matter structure in a sample of patients with first-episode psychosis.

Method

Sixty patients underwent assessment of minor physical anomalies with the Lane scale. High-resolution magnetic resonance images and voxel-based methods of image analysis were used to investigate brain structure in these patients.

Results

The total anomalies score was associated with a grey matter reduction in the prefrontal cortex and precuneus and with a grey matter excess in the basal ganglia, thalamus and lingual gyrus.

Conclusions

Minor physical anomalies in a sample of patients with first-episode psychosis are associated with regional grey matter changes. These regional changes may be important in the pathogenesis of psychotic disorder.

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Copyright

Corresponding author

Dr Kimberlie Dean, Department of Forensic Mental Health Science, PO Box 23, Institute of Psychiatry, De Crespigny Park, London SE5 8AF, UK. Tel: +44(0)20 7848 0771; fax: +44 (0)20 7848 0754; email: k.dean@iop.kcl.ac.uk

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Declaration of interest

None.

Footnotes

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Grey matter correlates of minor physical anomalies in the ÆSOP first-episode psychosis study

  • K. Dean (a1), P. Fearon (a1), K. Morgan (a1), G. Hutchinson (a2), K. Orr (a3), X. Chitnis (a4), J. Suckling (a5), R. Mallet (a6), J. Leff (a6), P. B. Jones (a5), R. M. Murray (a1) and P. Dazzan (a1)...
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