Skip to main content Accessibility help
×
Home

Glucose Metabolic Rate in Normals and Schizophrenics During the Continuous Performance Test Assessed by Positron Emission Tomography

  • Monte S. Buchsbaum (a1), Keith H. Nuechterlein (a2), Richard J. Haier (a1), Joseph Wu (a1), Nancy Sicotte (a1), Erin Hazlett (a1), Robert Asarnow (a2), Stephen Potkin (a1) and Steven Guich (a1)...

Abstract

Local cerebral uptake of glucose labelled with fluorine-18 was measured by positron emission tomography in 13 patients with schizophrenia and 37 right-handed volunteers. Patients received no medication for a minimum of 31 days and a mean of 30 weeks. The subjects were administered the labelled deoxyglucose just after the beginning of a 32-minute sequence of blurred numbers as visual stimuli for the Continuous Performance Test. In normal controls, task performance was associated with increases in glucose metabolic rate in the right frontal and right temporoparietal regions; occipital rates were unchanged. Patients with schizophrenia showed both absolutely and relatively reduced metabolic rates in the frontal cortex and in the temporoparietal regions compared with normal controls.

Copyright

Corresponding author

Correspondence

References

Hide All
Andreasen, N. C. (1982) Negative symptoms in schizophrenia: definition and reliability. Archives of General Psychiatry, 39, 784788.
Arsarnow, R. F. (1982) Schizophrenia. In The Child at Risk (ed. Tartar, R.). New York: Oxford University Press.
Arsarnow, R. F. & MacCrimmon, D. J. (1978) Residual performance deficit in clinically remitted schizophrenics: a marker of schizophrenia. Journal of Abnormal Psychology, 87, 597608.
Bartko, J. (1990) The power of analysis: statistical perspectives. Part 1. Psychiatry Research (in press).
Buchsbaum, M. S. & Rieder, R. O. (1979) Biologic heterogeneity and psychiatric research: platelet MAO as a case study. Archives of General Psychiatry, 36, 11631169.
Buchsbaum, M. S., Ingvar, D. H., Kessler, R., et al (1982) Cerebral glucography with positron emission tomography. Archives of General Psychiatry, 39, 251259.
Buchsbaum, M. S., Holcomb, H. H., Johnson, J., et al (1983) Cerebral metabolic consequences of electrical stimulation in normal individuals. Human Neurobiology, 2, 3538.
Buchsbaum, M. S., & Haier, R. J. (1983) Psychopathology: biological approaches. Annual Review of Psychology, 34, 401430.
Buchsbaum, M. S., DeLisi, L. E., Holcomb, H. H., et al (1984) Anteroposterior gradients in cerebral glucose use in schizophrenia and affective disorders. Archives of General Psychiatry, 41, 11591166.
Buchsbaum, M. S., Awsare, S. V., Holcomb, H. H., et al (1986) Topographic differences between normals and schizophrenics: the N120 evoked potential component. Neuropsychobiology, 15, 16.
Buchsbaum, M. S., & Haier, R. J. (1987) Functional and anatomical brain imaging: impact on schizophrenia research. Schizophrenia Bulletin, 13, 115132.
Cohen, R. M., Semple, W. E., Gross, M., et al (1987) Dysfunction in a prefrontal substrate of sustained attention in schizophrenia. Life Sciences, 40, 20312039.
Davies, D. R. & Parasuraman, R. (1982) The Psychology of Vigilance. London: Academic Press.
Davis, G. C., Buchsbaum, M. S. & Bunney, W. E. Jr (1979a) Research in endorphins and schizophrenia. Schizophrenia Bulletin, 5, 244250.
Davis, G. C., Buchsbaum, M. S. van Kammen, D. P., et al (1979b) Analgesia to pain stimuli in schizophrenics and its reversal by naltrexone. Psychiatry Research, 1, 6169.
Dixon, W. J. (1982) BMD Biomedical Computer Programs. Berkeley: University of California Press.
Early, T. S., Reiman, E. M., Raichle, M. E., et al (1987) Left globus pallidus abnormality in never-medicated patients with schizophrenia. Proceedings of the National Academy of Sciences, 84, 561563.
Erlenmeyer-Kimling, L. & Cornblatt, B. (1978) Attentional measures in a study of children at high risk for schizophrenia. Journal of Psychiatric Research, 14, 9398.
Farkas, T., Wolf, A. P., Jaeger, J., et al (1984) Regional brain glucose metabolism in chronic schizophrenia: a positron emission transaxial tomographic study. Archives of General Psychiatry, 41, 293300.
Gur, R. E., Resnick, S. M., Alavi, A., et al (1987) Regional brain function in schizophrenia. Positron emission tomography study. Archives of General Psychiatry, 44, 119125.
Hellige, J. B. (1982) Visual laterality and hemisphere specialization: methodological and theoretical considerations. In Conditioning, Cognition, and Methodology: Contemporary Issues in Experimental Psychology. Hillsdale, New Jersey: Erlbaum.
Ingvar, D. H. (1979) Hyperfrontal distribution of the cerebral grey matter flow in resting wakefulness. Acta Neurologica Scandinavica, 60, 1225.
Ingvar, D. H. & Franzen, G. (1974) Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatrica Scandinavica, 50, 425462.
Ingvar, D. H., Rosen, I., Eriksson, M., et al (1976) Activation patterns induced in the dominant hemisphere by skin stimulation. In Sensory Functions of the Skin (ed. Zotterman, Y.), pp. 549559. London: Pergamon Press.
Jernigan, T. L., Sargent, T. III, Pfefferbaum, A., et at (1985) 18-Fluorodeoxyglucose PET in schizophrenia. Psychiatry Research, 16, 317330.
Kling, A. S., Metter, E. J., Riege, W. H., et al (1986) Comparison of PET measurement of local brain glucose metabolism and CAT measurement of brain atrophy in chronic schizophrenia and depression. American Journal of Psychiatry, 143, 175180.
Levin, S. (1984) Frontal lobe dysfunctions in schizophrenia – I. Eye movement impairments. Journal of Psychiatric Research, 18, 2755.
Lukoff, D., Nuechterlein, K. H. & Ventura, J. (1986) Manual for expanded brief psychiatric rating scale (BPRS). Schizophrenia Bulletin, 12, 594602.
Matsui, T. & Hirano, A. (1978) An Atlas of the Human Brain for Computerized Tomography. Tokyo: Igaku-Shoin.
Matthysse, S. (1986) The art of questioning oracles. McLean Hospital Journal, 11, 6571.
Mesulam, M-M. (1985) Attention, confusional states, and neglect. In Principles of Behavioral Neurology (ed. Mesulam, M-M.). Philadelphia: F. A. Davis.
Mirsky, A. F. & Duncan, C. C. (1989) Attention impairment in human clinical disorders: schizophrenia and petit mal epilepsy. In Attention: Theory, Brain Functions and Clinical Applications (eds Sheer, D. E. & Pribram, K. H.). Hillsdale, New Jersey: Erlbaum.
Moscovitch, M. (1979) Information processing in the cerebral hemispheres. In Handbook of Behavioral Neurobiology, Vol 2: Neuropsychology (ed. Gazzaniga, M. S.). New York: Plenum.
Nuechterlein, K. H. (1983) Signal detection in vigilance tasks and behavioral attributes among offspring of schizophrenic mothers and among hyperactive children. Journal of Abnormal Psychology, 92, 428.
Nuechterlein, K. H., Phipps-Yonas, S., Driscoll, R. M., et al (1982) The role of different components of attention in children vulnerable to schizophrenia. In Preventive Intervention in Schizophrenia: Are We Ready? (ed. Goldstein, M. J.). Washington, DC: US Government Printing Office.
Nuechterlein, K. H., Parasuraman, R. & Jiang, Q. (1983) Visual sustained attention: image degradation produces rapid decrement over time. Science, 220, 327329.
Overall, J. E. & Gorham, D. R. (1962) The brief psychiatric rating scale. Psychological Reports, 10, 799812.
Orzack, M. & Kornetsky, C. (1966) Attention dysfunction in chronic schizophrenia. Archives of General Psychiatry, 14, 323326.
Orzack, M. & Kornetsky, C. (1971) Environmental and familial predictors of attention behavior in chronic schizophrenics. Journal of Psychiatric Research, 9, 2129.
Phelps, M. E., Huang, S. C., Hoffman, E. J., et al (1979) Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: validation of method. Annals of Neurology, 6, 371388.
Phelps, M. E., Mazziotta, J. C., Kuhl, D. E., et al (1981) Tomographic mapping of human cerebral metabolism: visual stimulation and deprivation. Neurology, 31, 517529.
Posner, M. I. & Presti, D. (1987) Selective attention and cognitive control. Trends in Neuroscience, 10, 1217.
Rutschmann, J., Cornblatt, G. & Erlenmeyer-Kimling, L. (1977) Sustained attention in children at risk for schizophrenia. Archives of General Psychiatry, 34, 571575.
Sergent, J. (1983) Role of the input in visual hemispheric asymmetries. Psychological Bulletin, 93, 481512.
Sheppard, G., Gruzelier, J., Manchanda, R., et al (1983) Positron emission tomographic scanning in predominantly never-treated acute schizophrenic patients. Lancet, ii, 14481452.
Sokoloff, L. (1977) Relation between physiological function and energy metabolism in the central nervous system. Journal of Neurochemistry, 29, 1326.
Strandburg, R. J., Marsh, J. T., Brown, W. S., et al (1984) Event-related potential concomitants of information processing dysfunction in schizophrenic children. Electro-encephalography and Clinical Neurophysiology, 57, 236253.
Tsubokawa, T., Katayama, Y., Ueno, Y., et al (1981) Evidence for involvement of the frontal cortex in pain-related cerebral events in cats: increase in local cerebral blood flow by noxious stimuli. Brain Research, 217, 179185.
Volkow, N. D., Wolf, A. P., van Gelder, P., et al (1987) Phenomenological correlates of metabolic activity in 18 patients with chronic schizophrenia. American Journal of Psychiatry, 144, 151158.
Walker, E. (1981) Attentional and neuromotor functions of schizophrenics, schizoaffectives, and patients with other affective disorders. Archives of General Psychiatry, 38, 13551358.
Walker, E. & Shaye, J. (1982) Familial schizophrenia: a predictor of neuromotor and attentional abnormalities in schizophrenia. Archives of General Psychiatry, 39, 11531156.
Weinberger, D. R. (1987) Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry, 44, 660669.
Weinberger, D. R., Berman, K. F., & Zec, R. F. (1986) Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia: I. Regional cerebral blood flow evidence. Archives of General Psychiatry, 43, 114124.
Wiesel, F.-A., Blomqvist, G., Greitz, T., et al (1985) In Proceedings of the 4th World Congress of Biological Psychiatry. New York: Elsevier Science Publishing Co.
Wiesel, F.-A., Blomqvist, G., Greitz, T., et al (1987) In Proceedings of the 4th World Congress of Biological Psychiatry. New York: Elsevier Science Publishing Co.
Wing, J. K., Cooper, J. E., & Sartorius, N. (1974) Measurement and Classification of Psychiatric Symptoms. London: Cambridge University Press.
Wohlberg, G. W. & Kornetsky, C. (1973) Sustained attention in remitted schizophrenics. Archives of General Psychiatry, 28, 533537.
Wolkin, A., Jaeger, J., Brodie, J. D., et al (1985) Persistence of cerebral metabolic abnormalities in chronic schizophrenia as determined by positron emission tomography. American Journal of Psychiatry, 142, 564571.

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Glucose Metabolic Rate in Normals and Schizophrenics During the Continuous Performance Test Assessed by Positron Emission Tomography

  • Monte S. Buchsbaum (a1), Keith H. Nuechterlein (a2), Richard J. Haier (a1), Joseph Wu (a1), Nancy Sicotte (a1), Erin Hazlett (a1), Robert Asarnow (a2), Stephen Potkin (a1) and Steven Guich (a1)...
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *