Skip to main content Accessibility help
×
Home

Family History Study of Anorexia Nervosa and Bulimia

  • James I. Hudson, Harrison G. Pope, Jeffrey M. Jonas and Deborah Yurgelun-Todd

Summary

The 420 first-degree relatives of 14 patients with anorexia nervosa, 55 patients with bulimia, and 20 patients with both disorders were evaluated for the presence of psychiatric illness, using DSM-III criteria, by the family history method. The morbid risk for affective disorder in the families of the eating disorder probands was similar to that found in the families of patients with bipolar disorder; but was significantly greater than that found in the families of patients with schizophrenia or borderline personality disorder. These results add to the growing evidence that anorexia nervosa and bulimia are closely related to affective disorder.

Copyright

References

Hide All
American Psychiatric Association. (1980) DSM-III: Diagnostic and Statistical Manual of Mental Disorders. (Third edition). Washington, DC: American Psychiatric Association.
Andreason, N. C., Endicott, J., Spitzer, R. L. & Winokur, G. (1977) The family history method using diagnostic criteria. Archives of General Psychiatry, 34, 1229–35.
Boyar, R. M., Hellman, L. D., Roffward, H. P., Katz, J., Zumoff, B., O'Connor, J., Bradlow, H. D. & Fukushima, D. K. (1977) Cortisol secretion and metabolism in anorexia nervosa. New England Journal of Medicine, 296, 190–3.
Cantwell, D. P., Sturzenberger, S., Burroughs, J., Salkin, B. & Green, J. D. (1977) Anorexia nervosa: an affective disorder? Archives of General Psychiatry, 34, 1087–93.
Carroll, B. F. Feinberg, M., Groden, J. F., Tarika, J., Albala, A. A., Haskett, R. F., James, N. M., Kronfol, Z., Lohr, N., Steiner, M., de Vigne, J. P. & Young, E. (1981) A specific laboratory test for the diagnosis of melancholia: standardization, validation, and clinical utility. Archives of General Psychiatry, 38, 1522.
Casper, R. C., Eckert, E. D., Halmi, K. A., Goldberg, S. C. & Davis, J. M. (1980) Bulimia: its incidence and clinical importance in patients with anorexia nervosa. Archives of General Psychiatry, 37, 1030–35.
Crisp, A. H., Hsu, L. K. G., Harding, B. & Hartshorn, J. (1980) Clinical features of anorexia nervosa. Journal of Psychosomatic Research, 24, 179–91.
Eckert, E. D., Goldberg, S. C., Halmi, K. A., Casper, R. C. & Davis, J. M. (1982) Depression in anorexia nervosa. Psychological Medicine, 12, 115–22.
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 5763.
Folstein, M. F., Wakeling, A & DeSouza, V. (1977) Analogue scale measurement of the symptoms of patients suffering from anorexia nervosa. in Anorexia Nervosa (ed. R. A. Vigersky). New York: Raven Press.
Garfinkel, P. E., Moldofsky, H. & Garner, D. M. (1980) The heterogeneity of anorexia nervosa: bulimia as a distinct subgroup. Archives of General Psychiatry, 37, 1036–40.
Gerner, R. H. & Gwirtsman, H. E. (1981) Abnormalities of dexamethasone suppression test and urinary MHPG in anorexia nervosa. American Journal of Psychiatary, 138, 652–3.
Gershon, E. S., Hamovit, J. R., Schreiber, J. L., Dibble, E. D., Kaye, W., Nurnberger, J. I. Jr., Andersen, A. & Ebert, M. (1982) Anorexia nervosa and major affective disorders associated in families. Paper presented at the Annual Meeting of the American Psychopathological Association, March 1, 1982, New York.
Gross, H. A., Ebert, M. H., Faden, V. B., Goldberg, S. C., Nee, L. E. & Kaye, W. H. (1981) A double-blind controlled trial of lithium carbonate in primary anorexia nervosa. Journal of Clinical Psychopharmacology, 1, 376–81.
Hudson, J. I., Laffer, P. S. & Pope, H. G. Jr. (1982) Bulimia related to affective disorder by family history and response to the dexamethasone suppression test. American Journal of Psychiatry, 137, 695–7.
Hsu, L. K. G., Crisp, A. H. & Harding, B. (1979) Outcome of anorexia nervosa. Lancet, i, 61–5.
Jonas, J. M., Hudson, J. I. & Pope, H. G. Jr. Treatment of bulimia with monoamine oxidase inhibitors. Journal of Clinical Psychopharmacology, in press.
Mendlewicz, J., Fleiss, J. L., Cataldo, M. & Rainer, J. D. (1975) Accuracy of the family history method in affective illness. Archives of General Psychiatry, 32, 309–14.
Mills, I. H. (1976) Amitriptyline therapy in anorexia nervosa. Lancet, 2, 687.
Morgan, H. G. & Russell, G. F. M. (1975) Value of family background in clinical features as predictors of long-term outcome in anorexia nervosa: four-year follow-up study of 41 patients. Psychological Medicine, 5, 355–71.
Needleman, H. L. & Waber, D. (1976) Amitriptyline therapy in patients with anorexia nervosa. Lancet, 2, 580.
Nogami, Y. & Yabana, F. (1977) On kibarashi-gui (binge-eating). Folia Psychiatrica et Neurologica Japonica, 31, 159–66.

Family History Study of Anorexia Nervosa and Bulimia

  • James I. Hudson, Harrison G. Pope, Jeffrey M. Jonas and Deborah Yurgelun-Todd

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.

Family History Study of Anorexia Nervosa and Bulimia

  • James I. Hudson, Harrison G. Pope, Jeffrey M. Jonas and Deborah Yurgelun-Todd
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *