Skip to main content Accessibility help
×
Home

Familial Transmission of Major Affective Disorders: Is there Evidence Supporting the Distinction between Unipolar and Bipolar Disorders?

  • Ming T. Tsuang (a1), Stephen V. Faraone (a2) and Jerome A. Fleming (a3)

Summary

The two-threshold multifactorial polygenic (MFP) model was applied to blind family study data, collected in a long-term follow-up and family study of major affective disorders. This model tested whether bipolar and unipolar disorders are manifestations of the same underlying factors or if they are independently caused disorders. The hypothesis that bipolar and unipolar disorders are, respectively, severe and mild forms of the same disorder was supported. There was little evidence for different familial aetiologies for bipolar and unipolar disorders in our sample.

Copyright

References

Hide All
Baron, M., Klotz, J., Mendlewicz, J. & Rainer, J. (1981) Multiple-threshold transmission of affective disorders. Archives of General Psychiatry, 38, 7984.
Bertelsen, A. (1979) In Prevention and Treatment of Affective Disorders, (ed. Schou, M and Stromgren, E.) pp. 227239, London: Academic Press.
Bertelsen, A., Harvald, B. & Hauge, M. (1977) A Danish study of manic-depressive disorders. British Journal of Psychiatry, 130, 330351.
Falconer, D. S. (1965) The inheritance of liability to certain diseases estimated from incidence among relatives. Annals of Human Genetics, 29, 5176.
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 5763.
Gershon, E. S., Baron, M. & Leckman, J. F. (1975) Genetic models of the transmission of affective disorders. Journal of Psychiatric Research, 12, 301317.
Gershon, E. S., Baron, M. & Hamovit, J., Guroff, J. J., Dibble, E., Leckman, J. F., Sceery, , et al (1982) A family study of Schizoaffective, Bipolar I, Bipolar II, Unipolar, and Normal Control Probands. Archives of General Psychiatry, 39, 11571167.
Kaplan, E. B. & Elston, R. C. (1972) A subroutine package for maximum likelihood estimation (MAXLIK). Institute of Statistics Mimeo Series No. 823, University of North Carolina.
Kiloh, L. G. & Garside, R. F. (1963) The independence of neurotic depression and endogenous depression. British Journal of Psychiatry, 109, 451463.
Mendlewicz, J. & Rainer, J. D. (1974) Morbidity risk and genetic transmission in manic-depressive illness. American Journal of Human Genetics, 26, 692701.
Mendlewicz, J. & Rainer, J. D. (1977) Adoption study supporting genetic transmission in manic-depressive illness. Nature, 268, 327329.
Morrison, J., Clancy, J., Crowe, R. & Winokur, G. (1972) The Iowa 500: I. Diagnostic validity in mania, depression and schizophrenia. Archives of General Psychiatry, 27, 457461.
Nelson, J. C. & Charney, D. S. (1980) Primary affective disorder criteria and the endogenous-reactive distinction. Archives of General Psychiatry, 37, 787793.
Perris, C. (1966) A study of bipolar (manic-depressive) and unipolar recurrent depressive psychoses. Acta Psychiatrica Scandinavica, Supplement 194.
Perris, C. (1973) The genetics of affective disorders. In Biological Psychiatry, (ed. Mendels, J.), New York: John Wiley.
Reich, T., James, J. W. & Morris, C. A. (1972) The use of multiple thresholds in determining the mode of transmission of semi– continuous traits. Annals of Human Genetics, 36, 163184.
Reich, T., & Morris, C. A., Rice, J., Cloninger, C. R., Wette, R. & James, J. W. (1979) The use of multiple thresholds and segregation analysis in analyzing the phenotypic heterogeneity of multifactorial traits. Annals of Human Genetics, 42, 371389.
Tsuang, M. T. (1975) Genetics of affective disorder. In Psychobiology of Depression (ed. Mendels, J.) New York: John Wiley.
Tsuang, M. T., Woolson, R. F. & Fleming, J. A. (1979) Long-term outcome of major psychoses: I. Schizophrenia and affective disorders compared with psychiatrically symptom-free surgical conditions. Archives of General Psychiatry, 39, 12951301.
Tsuang, M. T., Woolson, R. F. & Fleming, J. A. Winokur, G. & Crowe, R. R. (1980a) Morbidity risks of schizophrenia and affective disorders among first degree relatives of patients with schizophrenia, mania, depression and surgical conditions. British Journal of Psychiatry, 137, 497504.
Tsuang, M. T., & Fleming, J. A. Winokur, G. & Crowe, R. R., Woolson, R. F. & Simpson, J. C. (1980b) The Iowa Structured Psychiatric Interview: Rationale, reliability and validity. Acta Psychiatrica Scandinavica, Suppl. 283, 62.
Winokur, G., Cadoret, R., Dorzab, J. & Baker, M. (1971) Depressive disease: A genetic study. Archives of General Psychiatry, 24, 135155.
Zerbin-Rudin, E. (1980) Genetics of affective psychoses. In Handbook of Biological Psychiatry. Part III (ed. van Praag, H. et al). New York: Marcel Dekker.

Familial Transmission of Major Affective Disorders: Is there Evidence Supporting the Distinction between Unipolar and Bipolar Disorders?

  • Ming T. Tsuang (a1), Stephen V. Faraone (a2) and Jerome A. Fleming (a3)

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Familial Transmission of Major Affective Disorders: Is there Evidence Supporting the Distinction between Unipolar and Bipolar Disorders?

  • Ming T. Tsuang (a1), Stephen V. Faraone (a2) and Jerome A. Fleming (a3)
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *