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Expanded CAG/CTG Repeats in Schizophrenia: A Study of Clinical Correlates

  • Alastair G. Cardno (a1), Kieran C. Murphy (a1), Lisa A. Jones (a1), Carol A. Guy (a1), Philip Asherson (a1), Maria H. P. De Azevedo (a2), Isabel M. O. Da Cruz Coelho (a2), Antonio J. F. De Macedo e Santos (a2), Carlos N. Pato (a2), Peter McGuffin (a1), Michael J. Owen (a1) and Michael C. O'Donovan (a1)...

Abstract

Background

Schizophrenia is associated with expanded CAG/CTG trinucleotide repeats. We wished to determine whether the presence of such expansions correlated with specific subsyndromes or other clinical features of schizophrenia.

Method

Seventy patients from England and Wales and 44 patients from Portugal with a DSM–III–R diagnosis of schizophrenia were rated on the opcrit checklist Patients' maximum CAG/CTG repeat length was measured using repeat expansion detection (RED). Significant differences were sought for repeat lengths in subjects categorised according to dimensional and categorical schizophrenia subsyndromes, affective episodes, individual symptoms, and a range of demographic variables.

Results

Maximum CAG/CTG repeat length did not differ significantly for any of the clinical or demographic variables studied.

Conclusion

There are no subsyndromes or other clinical features of schizophrenia associated with CAG/CTG repeat expansion. Therefore, the identification of the gene(s) that contain expanded CAG/CTG repeats and which are associated with schizophrenia is unlikely to be facilitated at present by using any subsyndromes of schizophrenia as phenotypes.

Copyright

Corresponding author

Dr A. Cardno, Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN, UK

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Expanded CAG/CTG Repeats in Schizophrenia: A Study of Clinical Correlates

  • Alastair G. Cardno (a1), Kieran C. Murphy (a1), Lisa A. Jones (a1), Carol A. Guy (a1), Philip Asherson (a1), Maria H. P. De Azevedo (a2), Isabel M. O. Da Cruz Coelho (a2), Antonio J. F. De Macedo e Santos (a2), Carlos N. Pato (a2), Peter McGuffin (a1), Michael J. Owen (a1) and Michael C. O'Donovan (a1)...

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Expanded CAG/CTG Repeats in Schizophrenia: A Study of Clinical Correlates

  • Alastair G. Cardno (a1), Kieran C. Murphy (a1), Lisa A. Jones (a1), Carol A. Guy (a1), Philip Asherson (a1), Maria H. P. De Azevedo (a2), Isabel M. O. Da Cruz Coelho (a2), Antonio J. F. De Macedo e Santos (a2), Carlos N. Pato (a2), Peter McGuffin (a1), Michael J. Owen (a1) and Michael C. O'Donovan (a1)...
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