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Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography

  • Nicola G. Cascella (a1), Godfrey Pearlson (a2), Dean F. Wong (a3), Emmanuel Broussolle (a4), Craig Nagoshi (a4), Richard A. Margolin (a4) and Edythe D. London (a4)...

Abstract

Computerised tomography (CT) was used to assess the possible effects of substance abuse on brain morphology. Polydrug abusers had significantly wider third ventricles than normal controls, with a positive correlation between age and ventricle:brain ratio (VBR). Assuming no effect of age, estimated quantity of substance abuse was not significantly related to ventricular and sulcal measures, except that alcohol consumption correlated positively with VBR and severity of cocaine use correlated negatively with sulcal width. When age of the subjects was partialled out, alcohol use showed a tendency for association with VBR; however, severity of cocaine use did not remain a significant predictor of cortical sulcal width. The findings suggest that chronic use of alcohol, but not necessarily of other commonly abused substances, produces brain atrophy.

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NIDA Addiction Research Center, PO Box 5180, Baltimore, MD 21224, USA

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Presented in part at the 50th Annual Meeting of the Committee on Problems of Drug Dependence, North Falmouth, MA, 28–30 June 1988.

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References

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American Psychiatric Association (1980) Diagnostic and Statistical Manual of Mental Disorders (3rd edn) (DSM–III). Washington, DC: APA.
Artmann, H., Gall, M. V., Hacker, H., et al (1981) Reversible enlargement of cerebral spinal fluid spaces in chronic alcoholics. American Journal of Neuroradiology, 2, 2327.
Cala, L. A. & Mastaglia, F. L. (1980) Computerized axial tomography in the detection of brain damage. 1. Alcohol, nutritional deficiency and drugs of addiction. Medical Journal of Australia, 2, 193198.
Carlen, P. L., Penn, R. D., Fornazzari, L., et al (1986) Computerized tomographic scan assessment of alcoholic brain damage and its potential reversibility. Alcoholism: Clinical and Experimental Research, 10, 226232.
Courville, C. B. (1955) Effects of Alcohol on the Nervous System of Man. Los Angeles: San Lucas Press.
Hill, S. Y. & Mikhael, M. A. (1979) Computerized transaxial tomographic and neuropsychological evaluations in chronic alcoholics and heroin abusers. American Journal of Psychiatry, 136, 598602.
Horvath, T. B. (1975) Clinical spectrum and epidemiological features of alcoholic dementia. In Alcohol, Drugs and Brain Damage (ed. Rankin, J. G.). Toronto: Alcoholism and Drug Addiction Research Foundation of Ontario.
Ishii, T. (1983) A comparison of cerebral atrophy in CT scan findings among alcoholic groups. Acta Psychiatrica Scandinavica (suppl. 309), 130.
Kozlowski, L. T., Herling, S., Leigh, G., et al (1984) The Role of Cigarette Smoking and Caffeine Use in Drug and Alcohol Abuse (New Research Abstract). Toronto: American Psychological Association.
Largen, J. W., Smith, R. C., Calderon, M., et al (1984) Abnormalities of brain structure and density in schizophrenia. Biological Psychiatry, 19, 9911011.
Lee, K., Moller, L., Hardt, F., et al (1979) Alcohol induced brain damage and liver damage in young males. Lancet, ii, 759761.
Leeds, N. E., Malhotra, V. & Zimmerman, R. D. (1983) The radiology of drug addiction affecting the brain. Seminars in Roentgenology, 3, 227233.
Lishman, W. A., Ron, M. & Acker, W. (1980) Computed tomography of the brain and psychometric assessment of alcoholic patients – a British study. In Pharmacology of Alcohol (ed. Sandler, M.). New York: Raven Press.
McLellan, A. T., Luborsky, L., Woody, G. E., et al (1980) An improved diagnostic evaluation instrument for substance abuser patients: The Addiction Severity Index. Journal of Nervous and Mental Disease, 168, 2633.
Pearlson, G. D., Garbacz, D. J., Moberg, P. J., et al (1985) Symptomatic, familial, perinatal and social correlates of computerized axial tomography (CAT) changes in schizophrenics and bipolars. Journal of Nervous and Mental Disease, 173, 4250.
Pearlson, G. D., Kim, W. S. & Kudos, K. L. (1989) VBR, CT density and brain area in 50 schizophrenics. Archives of General Psychiatry, 46, 690697.
Pfefferbaum, A., Zatz, L. M. & Jernigan, T. (1986) Computer-interactive method for quantifying cerebrospinal fluid and tissue in brain CT scans: effects of aging. Journal of Computer Assisted Tomography, 10, 571578.
Pfefferbaum, A., Rosenbloom, M., Crusan, K., et al (1988) Brain CT changes in alcoholics; effects of age and alcohol consumption. Alcoholism: Clinical and Experimental Research, 12, 8187.
Robins, L. N., Helzer, J. E., Croughan, T., et al (1981) NIMH Diagnostic Interview Schedule: Version III. Washington, DC: Public Health Service.
Roizin, L., Halpern, M., Baden, M. M., et al (1972) Neuropathology of drugs of dependence. In Chemical and Biological Aspects of Drug Dependence (ed. Mule, S. J.). New York: CRC Press.
Ron, M. A. (1983) The alcoholic brain: CT scan and psychological findings. Psychological Medicine (monograph suppl. 3), 133.
Ron, M. A., Acker, W. & Lishman, W. A. (1980) Morphological abnormalities in the brains of chronic alcoholics – a clinical, psychological and computerized axial tomographic study. Acta Psychiatrica Scandinavica (suppl.), 4146.
Rumbaugh, C. L., Fang, H. C. H., Wilson, G. H., et al (1980) Cerebral CT findings in drug abuse: clinical and experimental observations. Journal of Computer Assisted Tomography, 4, 330334.
Synek, V., Reuben, J. R. & Du Boulay, G. H. (1976) Comparing Evans' index and computerized axial tomography in assessing relationship of ventricular size to brain size. Neurology, 26, 231233.
Wilkinson, A. D. (1982) Examination of alcoholics by computed tomographic (CT) scans: a critical review. Alcoholism: Clinical and Experimental Research, 6, 3145.
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Effects of Substance Abuse on Ventricular and Sulcal Measures Assessed by Computerised Tomography

  • Nicola G. Cascella (a1), Godfrey Pearlson (a2), Dean F. Wong (a3), Emmanuel Broussolle (a4), Craig Nagoshi (a4), Richard A. Margolin (a4) and Edythe D. London (a4)...
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