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Chronic Schizophrenic Disorder

I. Psychophysiological Responses, Laterality and Social Stress

Published online by Cambridge University Press:  02 January 2018

C. White ,
J. Farley  and
P. Charles
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Abstract

Bilateral palmar skin conductance and heart rate were measured throughout a series of psychological tests and during both sitting and ambulant social interactions in 14 right-handed men with chronic schizophrenic disorder and 12 healthy volunteers matched for age and handedness. Miniature radio telemetry equipment was used to collect the physiological data. The schizophrenic group was effectively unresponsive to 70-dB auditory stimuli, while all but one of the control group responded and habituated to a nil response by the tenth tone in sequence. The schizophrenic group showed some evidence of increased skin conductance activity at rest, and in socially demanding conditions skin conductance level and variability were increased in the right hand. The present group of electrodermal ‘non-responders' was not in general autonomically underactive. Asymmetry of skin conductance activity during social interaction may be a characteristic of chronic schizophrenic disorder.

Type
Research Article
Information
The British Journal of Psychiatry , Volume 150 , Issue 3 , March 1987 , pp. 365 - 373
Copyright
Copyright © 1987 The Royal College of Psychiatrists 

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References

Ax, A. F., Bamford, J. L., Beckett, P. G. S., Fretz, N. F. & Gttlieb, J. S. (1970) Autonomic conditioning in chronic schizophrenia. Journal of Abnormal Psychology, 76, 140–154.CrossRefGoogle ScholarPubMed
Bernstein, A. S. (1979) The orienting response as novelty and significance detector: reply to O'Gorman. Psychophysiology, 16, 263–273.CrossRefGoogle ScholarPubMed
Bernstein, A.S. Taylor, K. W., Starkey, P., Juni, S., Lubowsky, J. & Paley, H. (1981) Bilateral skin conductance, finger pulse volume, and EEG orienting response to tones of differing intensities in chronic schizophrenics and controls. Journal of Nervous and Mental Disease, 169, 513–528.CrossRefGoogle ScholarPubMed
Deakin, J. F. W., Baker, H. F., Frith, C. D., Joseph, M. H. & Johnstone, E. C. (1979) Arousal related to excretion of noradrenaline metabolites and clinical aspects of unmedicated chronic schizophrenic patients. Journal of Psychiatric Research, 15, 57–65.CrossRefGoogle ScholarPubMed
Depue, R. A. (1976) An activity-withdrawal distinction in schizophrenia: behavioural, clinical, brain damage and neurophysio-logical correlates. Journal of Abnormal Psychology, 85, 174–185.CrossRefGoogle Scholar
Depue, R.A. & Fowles, D. C. (1973) Electrodermal activity as an index of arousal in schizophrenics. Psychological Bulletin, 79, 233–238.CrossRefGoogle ScholarPubMed
Epstein, S. & Coleman, M. (1970) Drive theories of schizophrenia. Psychosomatic Medicine, 32, 113–140.CrossRefGoogle ScholarPubMed
Farley, J. D. (1976) Phylogenese adaptations and the genetics of psychosis. Acta Psychiatrica Scandinavica, 53, 173–192.CrossRefGoogle Scholar
Feighner, J. P., Robins, E., Guze, S. B., Woodruff, R. A., Winokur, G. & Munoz, R. (1972) Diagnostic criteria for use in psychiatric research. Archives of General Psychiatry, 26, 57–63.CrossRefGoogle ScholarPubMed
Fish, F. J. (1961) A neurophysiological theory of schizophrenia. Journal of Mental Science, 107, 828–839.CrossRefGoogle ScholarPubMed
Flekkoy, K. (1975) Psychophysiological and neurophysiological aspects of schizophrenia. Acta Psychiatrica Scandinavica, 51, 234–248.CrossRefGoogle ScholarPubMed
Freixai Baque, E., Catteau, M., Miossec, Y. & Roy, J. (1984) Asymmetry of electrodermal activity: a review. Biological Psychology, 18, 219–239.CrossRefGoogle Scholar
Germana, J. (1969) Central efferent processes and autonomic behavioural integration. Psychophysiology, 6, 78–90.CrossRefGoogle Scholar
Gruzelier, J. H. (1973) Bilateral asymmetry of skin conductance orienting activity and levels in schizophrenics. Biological Psychology, 1, 21–42.CrossRefGoogle ScholarPubMed
Gruzelier, J.H. (1976) Clinical attributes of schizophrenic skin conductance responders and non-responders. Psychological Medicine, 6, 245–249.CrossRefGoogle ScholarPubMed
Gruzelier, J.H. & Venables, P. H. (1972) Skin conductance orienting activity in a heterogeneous sample of schizophrenics: possible evidence of limbic dysfunction. Journal of Nervous and Mental Disease, 155, 277–287.CrossRefGoogle Scholar
Gruzelier, J.H. & Venables, P. H. (1974) Bimodality and lateral asymmetry of skin conductance orienting activity in schizophrenics: Replication and evidence of lateral asymmetry in patients with depression and disorders of personality. Biological Psychiatry, 8, 55–73.Google ScholarPubMed
Gruzelier, J.H. & Hammono, N. V. (1978) The effect of chlorpromazine upon psychophysiological, endocrine and information processing measures in schizophrenia. Journal of Psychiatric Research, 14, 167–182.CrossRefGoogle ScholarPubMed
Gruzelier, J.H. & Manchanda, R. (1982) The syndrome of schizophrenia: relations between electrodermal response, lateral asymmetries and clinical ratings. British Journal of Psychiatry, 141, 488–495.CrossRefGoogle ScholarPubMed
Gruzelier, J.H., Eves, F. F., Connolly, J. F. & Hirsch, S. R. (1981) Orienting, habituation, sensitisation and dishabituation in the electrodermal system of consecutive, drug-free, admissions for schizophrenia. Biological Psychology, 12, 187–209.CrossRefGoogle ScholarPubMed
Isamat, F. (1961) Galvanic skin responses from stimulation of limbic cortex. Journal of Neurophysiology, 24, 176–181.CrossRefGoogle ScholarPubMed
Johnstone, E. C, Frith, C. D., Gold, A., & Stevens, A. (1979) The outcome of severe acute schizophrenic illness after one year. British Journal of Psychiatry, 134, 28–33.CrossRefGoogle ScholarPubMed
Jordan, L. S. (1974) Electrodermal activity in schizophrenics: further considerations. Psychological Bulletin, 81, 85–91.CrossRefGoogle ScholarPubMed
Kasanin, J. (1932) Pavlov's theory of schizophrenia. Archives of Neurology, 23, 210–218.Google Scholar
Kennard, M. A. (1935) Vasomotor disturbances resulting from cortical lesions. Archives of Neurology and Psychiatry, 33, 537–545.CrossRefGoogle Scholar
Kennard, M. A., Viet, H. R., & Fulton, J. F. (1934) The syndrome of the premotor cortex in man. Brain, 57, 69–84.CrossRefGoogle Scholar
Kokes, R. F., Strauss, J. S. & Klorman, R. (1977) Premorbid adjustment in schizophrenia. Schizophrenia Bulletin, 3, 99–106.Google ScholarPubMed
Lader, M. H. (1975) The Psychophysiology of Mental Illness. London: Routledge & Kegan Paul.Google Scholar
Lang, P. J., Kozak, M. J., Miller, G. A., Levin, D. N. & McLean, A. (1980) Emotional imagery: conceptual structure and pattern of somato-visceral response. Psychophysiology, 17, 179–192.CrossRefGoogle ScholarPubMed
Lapidus, L. B. & Schmolling, P. (1975) Anxiety, arousal and schizophrenia: A theoretical integration. Psychological Bulletin, 82, 689–710.CrossRefGoogle ScholarPubMed
Lynn, R. (1963) Russian theory and research on schizophrenia. Psychological Bulletin, 60, 456–498.CrossRefGoogle ScholarPubMed
Maltzman, I. (1979) Orienting reflexes and significance: a reply to O'Gorman. Psychophysiology, 16, 274–282.CrossRefGoogle ScholarPubMed
Mednick, S. A. (1958) A learning theory approach to schizophrenia. Psychological Bulletin, 55, 316–327.CrossRefGoogle Scholar
Mirsky, A. F. (1969) Neurophysiological basis of schizophrenia. Annual Review of Psychology, 321–348.CrossRefGoogle Scholar
Netsky, M. G. & Starr, H. (1948) Autonomic functions of the frontal lobes: studies on patients with head trauma. In The Frontal Lobes (eds J. F. Fulton, C. D. Aring & S. B. Wortis). Baltimore: Williams & Wilkins.Google ScholarPubMed
O'Gorman, J. G. (1979) The orienting reflex: novelty or significance detector. Psychophysiology, 16, 253–262.CrossRefGoogle ScholarPubMed
Patterson, T. (1976) Skin conductance responding/nonresponding and pupillometrics in chronic schizophrenia: a confirmation of Gruzelier & Venables. Journal of Nervous & Mental Disease, 163, 200–209.CrossRefGoogle Scholar
Patterson, T. & Venables, P. H. (1978) Bilateral skin conductance and skin potential in schizophrenic and normal subjects: the identification of the fast habituator group of schizophrenics. Psychophysiology, 15, 556–560.CrossRefGoogle ScholarPubMed
Reynolds, G. P. (1983) Increased concentrations and lateral asymmetry of amygdala dopamine in schizophrenia. Nature, 305, 577–578.CrossRefGoogle ScholarPubMed
Schooler, C. & Zahn, T. P. (1968) The effect of closeness of social interaction on task performance and arousal in chronic schizophrenia. Journal of Nervous and Mental Disease, 147, 394–401.CrossRefGoogle ScholarPubMed
Schwarz, H. G. (1937) Effect of experimental lesions of the cortex on the psychogalvanic reflex of the cat. Archives of Neurology and Psychiatry, 38, 308–320.CrossRefGoogle Scholar
Straube, E. R. (1979) On the meaning of electrodermal nonresponding in schizophrenia. Journal of Nervous and Mental Disease, 167, 601–611.CrossRefGoogle ScholarPubMed
Sturgeon, D., Kuipers, L., Berkowitz, R., Turpin, G. & Leff, J. (1981) Psychophysiological responses of schizophrenic patients to high and low expressed emotion relatives. British Journal of Psychiatry, 138, 40–45.CrossRefGoogle ScholarPubMed
Tarrier, N., Vaughn, C, Lader, M. H. & Leff, J. P. (1979) Bodily reactions to people and events in schizophrenics. Archives of General Psychiatry, 36, 311–315.CrossRefGoogle ScholarPubMed
Toone, B. K., Cooke, E. & Lader, M. H. (1981) Electrodermal activity in the affective disorders and schizophrenia. Psychological Medicine, 11, 497–508.CrossRefGoogle ScholarPubMed
Venables, P. H. (1968) Experimental psychological studies of chronic schizophrenia. In Studies in Psychiatry (eds M. Shepherd & D. L. Davies). Oxford: Oxford University Press.Google Scholar
Venables, P. H. (1977) The electrodermal psychophysiology of schizophrenics and children at risk for schizophrenia: controversies and developments. Schizophrenia Bulletin, 3, 28–48.CrossRefGoogle ScholarPubMed
Venables, P. H. & Christie, M. J. (1980) Electrodermal activity. In Techniques in Psychophysiology (eds I. Martin & P. H. Venables). London: John Wiley.Google Scholar
White, C. de B. & Charles, I. P. (1983) Telemetrie skin conductance with computer interface. Psychophysiology, 20, 597–599.Google Scholar
White, C. de B., Farley, J. & Charles, I. P. (1987) Chronic schizophrenic disorder II. Reaction time, social performance and arousal. British Journal of Psychiatry, 150, 374–380.CrossRefGoogle ScholarPubMed
Wing, J. K. & Venables, P. H. (1962) Level of arousal and the subclassification of schizophrenics. Archives of General Psychiatry, 7, 114–119.Google Scholar
Wing, J. K. & Venables, P. H., Cooper, J. E. & Sartorius, N. (1974) Measurement and Classification of Psychiatric Symptoms, London: Cambridge University Press.Google Scholar
Zahn, T. P., Carpenter, W. T. & McGlashan, T. H. (1981) Autonomic nervous system activity in acute schizophrenia, I & II. Archives of General Psychiatry, 38, 251–266.CrossRefGoogle ScholarPubMed
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