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Chromosomal abnormalities and psychosis

  • Walter J. Muir (a1), Benjamin S. Pickard (a2) and Douglas H. R. Blackwood (a1)

Summary

The search for susceptibility genes for schizophrenia and severe affective disorder has been enhanced by the study of cytogenetic abnormalities that disrupt genes directly. One such gene is DISCI and there is increasing evidence that it may be an important modulator of risk of psychosis.

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Copyright

COPYRIGHT: © Royal College of Psychiatrists, 2006 

Corresponding author

Dr Walter J. Muir, Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK. E-mail: walter.muir@ed.ac.uk

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Declaration of Interest

None.

Funding detailed in Acknowledgements.

Footnotes

References

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Blackwood, D. H., Fordyce, A., Walker, M. T., et al (2001) Schizophrenia and affective disorders – cosegregation with a translocation at chromosome Iq42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. American Journal of Human Genetics, 69, 428–433.
Burdick, K. E., Hodgkinson, C. A., Szeszko, P. R., et al (2005) DISCI and neurocognitive function in schizophrenia. Neuroreport, 16, 1399–1402.
Callicott, J. H., Straub, R. E., Pezawas, L., et al (2005) Variation in DISCI affects hippocampal structure and function and increases risk for schizophrenia. Proceedings of the National Academy of Sciences of the USA, 102, 8627–8632.
Cannon, T. D., Hennah, W., van Erp, T. G., et al (2005) Association of DISCI/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Archives of General Psychiatry, 62, 1205–1213.
Doody, G. A., Johnstone, E. C., Sanderson, T. L., et al (1998) ‘Pfropfschizophrenie’ revisited. Schizophrenia in people with mild learning disability. British Journal of Psychiatry, 173, 145–153.
Ekelund, J., Hovatta, I., Parker, A., et al (2001) Chromosome I loci in Finnish schizophrenia families. Human Molecular Genetics, 10, 1611–1617.
Ekelund, J., Hennah, W., Hiekkalinna, T., et al (2004) Replication of 1942 linkage in Finnish schizophrenia pedigrees. Molecular Psychiatry, 9, 1037–1041.
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Hennah, W., Varilo, T., Kestila, M., et al (2003) Haplotype transmission analysis provides evidence of association for DISCI to schizophrenia and suggests sex-dependent effects. Human Molecular Genetics, 12, 3151–3159.
Hennah, W., Tuulio-Henriksson, A., Paunio, T., et al (2005) A haplotype within the DISCI gene is associated with visual memory functions in families with a high density of schizophrenia. Molecular Psychiatry, 10, 1097–1103.
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Millar, J. K., Pickard, B. S., Mackie, S., et al (2005) DISCI and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signalling. Science, 310, 1187–1191.
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Sawamura, N., Sawamura-Yamamoto, T., Ozeki, Y., et al (2005) A form of DISCI enriched in nucleus: altered subcellular distribution in orbitofrontal cortex in psychosis and substance/alcohol abuse. Proceedings of the National Academy of Sciences of the USA, 102, 1187–1192.
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  • Cited by 8

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Chromosomal abnormalities and psychosis

  • Walter J. Muir (a1), Benjamin S. Pickard (a2) and Douglas H. R. Blackwood (a1)

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  • Cited by 8

  • Access

Chromosomal abnormalities and psychosis

  • Walter J. Muir (a1), Benjamin S. Pickard (a2) and Douglas H. R. Blackwood (a1)
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