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Chromosomal abnormalities and psychosis

  • Walter J. Muir (a1), Benjamin S. Pickard (a2) and Douglas H. R. Blackwood (a1)

Summary

The search for susceptibility genes for schizophrenia and severe affective disorder has been enhanced by the study of cytogenetic abnormalities that disrupt genes directly. One such gene is DISCI and there is increasing evidence that it may be an important modulator of risk of psychosis.

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Copyright

Corresponding author

Dr Walter J. Muir, Division of Psychiatry, University of Edinburgh, Kennedy Tower, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, UK. E-mail: walter.muir@ed.ac.uk

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Declaration of Interest

None.

Funding detailed in Acknowledgements.

Footnotes

References

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Blackwood, D. H., Fordyce, A., Walker, M. T., et al (2001) Schizophrenia and affective disorders – cosegregation with a translocation at chromosome Iq42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. American Journal of Human Genetics, 69, 428433.
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Callicott, J. H., Straub, R. E., Pezawas, L., et al (2005) Variation in DISCI affects hippocampal structure and function and increases risk for schizophrenia. Proceedings of the National Academy of Sciences of the USA, 102, 86278632.
Cannon, T. D., Hennah, W., van Erp, T. G., et al (2005) Association of DISCI/TRAX haplotypes with schizophrenia, reduced prefrontal gray matter, and impaired short- and long-term memory. Archives of General Psychiatry, 62, 12051213.
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Chromosomal abnormalities and psychosis

  • Walter J. Muir (a1), Benjamin S. Pickard (a2) and Douglas H. R. Blackwood (a1)

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Chromosomal abnormalities and psychosis

  • Walter J. Muir (a1), Benjamin S. Pickard (a2) and Douglas H. R. Blackwood (a1)
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