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Changes in the Brain Catecholamines in Patients with Dementia of Alzheimer Type

  • R. Adolfsson (a1), C. G. Gottfries (a2), B. E. Roos (a3) and B. Winblad (a4)

Summary

Brain monoamine concentrations were determined post mortem in 19 patients with dementia of Alzheimer type. Samples were taken from 10 parts of the brain and compared with an age-matched control group.

There were lower mean concentrations of dopamine in the demented group of patients in seven regions of the brain, and two of these were at a significant level. There were also significantly lower concentrations of homovanillic acid in the nucleus caudatus and in the putamen. The means of the concentrations of noradrenaline were also lower, and in the putamen and the cortex gyrus frontalis significant differences were observed. The 5-hydroxytryptamine concentrations were slightly lower in the demented group but the differences did not reach significance. The degree of intellectual deterioration was negatively correlated with the noradrenaline concentrations in the hypothalamus and the cortex gyrus cinguli.

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Adolfsson, R., Gottfries, C.-G. & Winblad, B. (1978) Methodological aspects of post-mortem investigations of human brain—with special reference to monoamines and related enzymes. In Neuro-psychopharmacology (Proc. of the 10th CINP-meeting. Quebec, July, 1976). (Eds. Deniker, P., Radonco-Thomas, C. and Villeneuve, A.). Oxford: Pergamon Press, pp 1597–604.
Andén, N. E., Roos, B. E. & Werdinius, B. (1963) On the occurrence of homovanillic acid in brain and cerebrospinal fluid and its determination by a fluorimetric method. Life Sciences, 2, 448–50.
Andén, N. E. & Magnusson, T. (1967) An improved method for the fluorimetric determination of 5-hydroxytryptamine (5HT) in tissue. Acta Physiologica Scandinavica, 69, 8794.
Anlezark, G. M., Crow, T. J. & Greenway, A. P. (1973) Impaired learning and decreased cortical norepinephrine after bilateral locus coeruleus lesions. Science, 181, 682–4.
Bernheimer, H., Birkmayer, W. & Hornykiewicz, O. (1963) Zur Biochemie des Parkinson-Syndroms des Menschen: Einfluss der Monoaminoxydase-Hemmer-Therapie auf die Konzentration des Dopamins, Noradrenaline und 5-Hydroxytryptamine im Gehirn. Wiener Klinische Wochenschrift, 41, 465–9.
Bernheimer, H. & Hornykiewicz, O. (1965) Herabgesetzte Konzentration der Homovanillinsäure im Gehirn von parkinsonkranken Menschen als Ausdruck der Störung des zentralen Dopaminstoff-Wechsels. Wiener Klinische Wochenschrift, 43, 711–5.
Bernheimer, H., Birkmayer, W., Hornykiewicz, O., Jellinger, K. & Seitelberger, F. (1973) Brain dopamine and the syndromes of Parkinson and Huntington. Journal of the Neurological Sciences, 20, 415–55.
Bertler, Å., Carlsson, A. & Rosengren, E. (1958) A method for the fluorimetric determination of adrenaline and noradrenaline in tissues. Acta Physiologica Scandinavica, 44, 273–92.
Blessed, G., Tomlinson, B. E. & Roth, M. (1968) The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. British Journal of Psychiatry, 114, 797811.
Bowen, D. M., Smith, C. B. & Davison, A. N. (1973) Molecular changes in senile dementia. Brain, 96, 849–56.
Bowen, D. M., White, P., Flack, R. H. A., Smith, C. B. & Davison, A. N. (1974) Brain-decarboxylase activities as indices of pathological change in senile dementia. Lancet, 1, 1247–9.
Bowen, D. M., Smith, C. B., White, P. & Davison, A. N. (1976) Neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. Brain, 99, 459–96.
Carlsson, A. & Lindqvist, M. (1962) In-vivo decarboxylation of γ-methyl DOPA and γ-methyl metatyrosine. Acta Physiologica Scandinavka, 54, 8794.
Carlsson, A. & Lindqvist, M. (1963) Effect of chlorpromazine or haloperidol on formation of 3-methoxytyramine and norepinephrine in mouse brain. Acta Pharmacologica, 20, 140–4.
Carlsson, A. & Winblad, B. (1976) Influence of age and time interval between death and autopsy on dopamine and 3-methoxytyramine levels in human basal ganglia. Journal of Neural Transmission, 38, 271–6.
Colon, E. J. (1973) The cerebral cortex in presenile dementia. A quantitative analysis. Acta Neuropathologica (Berl.), 23, 281–90.
Davies, P. & Maloney, A. J. F. (1976) Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet, ii, 1403.
Dayan, A. D. (1974) The brain, ageing, and dementia. Psychological Medicine, 4, 349–52.
Drachman, D. A. & Levitt, J. (1974) Human memory and the cholinergic system. Archives of Neurology, Chicago, 30, 113–21.
Drachman, D. A. (1977) Memory and cognitive function in man: does the cholinergic system have a specific role? Neurology, 27, 783–90.
Engel, J. (1972) Neurochemistry and behaviour: a correlative study with special reference to central catecholamines. Göteborg: Thesis, Elanders Boktryckeri AB.
Fahn, S., Libsch, L. R. & Cutler, R. W. (1971) Monoamines in the human neostriatum: topographic distribution in normals and in Parkinson's disease and their role in akinesia, rigidity, chorea and tremor. Journal of the Neurological Sciences, 14, 427–55.
Fischer, R. H. (1975) The urinary excretion of homovanillic acid and 4-hydroxy-3-methoxy mandelic acid in the elderly demented. Gerontological Clinks, 14, 172–5.
Forno, L. S. (1966) Pathology of Parkinsonism. Journal of Neurosurgery, 24, Suppl. 2, 266–71.
Gonates, N. K. & Gambetti, P. (1970) The pathology of the synapse in Alzheimer's disease. In Alzheimer's Disease and Related Conditions. (Eds. Wolstenholme, G. W. W. and O'Connor, M.). London: Churchill, pp 169–83.
Gottfries, C. G. & Gottfries, I. (1968) Geriatriskt skattningsschema III. Stencil. S:t Lars sjukhus, Lund.
Gottfries, C. G., Gottfries, I. & Roos, B. E. (1969) The investigation of homovanillic acid in the human brain and its correlation to senile dementia. British Journal of Psychiatry, 115, 563–74.
Gottfries, C. G., Gottfries, I. & Roos, B. E. (1970) Homovanillic acid and 5-hydroxyindoleacetic acid in cerebrospinal fluid related to rated mental and motor impairment in senile and presenile dementia. Acta Psychiatrica Scandinavica, 46, 99105.
Gottfries, C. G. & Roos, B. E. (1973) Acid monoamine metabolites in cerebrospinal fluid from patients with presenile dementia (Alzheimer's disease). Acta Psychiatrica Scandinavica, 49, 257–63.
Gustafson, L., Brun, A. & Ingvar, D. H. (1977) Presenile dementia: clinical symptoms, pathoanatomical findings and cerebral blood flow. In Cerebral Vascular Disease. (Eds. Meyer, J., Lechner, H. and Reivich, M.). Amsterdam: Excerpta Medica, pp 59.
Häggendahl, J. (1963) An improved method for fluorimetric determination of small amounts of adrenaline and noradrenaline in plasma and tissues. Acta Physiologica Scandinavica, 59, 242–54.
Hornykiewicz, O. (1966) Dopamine (3-hydroxytryptamine) and brain function. Pharmacological Reviews, 18, 925–64.
Huckman, M. S., Fox, J. & Topel, J. (1975) The validity of criteria for the evaluation of cerebral atrophy by computerized tomography. Radiology, 116, 8592.
Johannesson, G., Brun, A., Gustafson, I. & Ingvar, D. H. (1977) EEG in presenile dementia related to cerebral blood flow and autopsy findings. Acta Neurologica Scandinavica, 56, 89103.
Jonsson, J. & Levander, T. (1970) A method for the simultaneous determination of 5-hydroxy-3-indoleamine (5HIAA) and 5-hydroxy-tryptamine (5HT) in brain tissue and cerebrospinal fluid. Acta Physiologica Scandinavica, 78, 4351.
Keller, H. H., Bartholini, G. & Pletscher, A. (1973) Increase of 3-methoxy-4-hydroxyphenylethylene glycol in rat brain by neuroleptic drugs. European Journal of Pharmacology, 23, 183–6.
Korf, J., Roos, B. E. & Werdinius, B. (1971) Fluorimetric determination of homovanillic acid (HVA) in tissues using union exchange separation and mixed solvent elimination. Acta Chemica Scandinavica, 25, 333–5.
Mehraein, P., Yamada, M. & Tarnowska-Dziduszko, E. (1975) Quantitative study on dendrites and dendritic spines in Alzheimer's disease and senile dementia. Advances in Neurology, 12, 453–8.
Murphy, D. L. (1972) L-dopa, behavioural activation and psychopathology. In Neurotransmitters (Res. publ. ass. res. nerv. ment. dis., vol. 50). Baltimore: Williams & Williams, pp 472–92.
Müller, C. & Ciompi, L. (1968) Senile Dementia. Bern: Hübergs.
Obrist, W. D., Sokoloff, L., Lassen, N. A., Lane, M. H., Butler, R. N. & Feinberg, J. (1963) Relation of EEG to cerebral blood flow and metabolism in old age. EEG Clinical Neurophysiology, 15, 510–19.
Parkes, J. E., Marsden, C. D., Rees, J. E., Curzon, G., Katamaneni, B. E., Knill-Jones, R., Akbar, A., Das, S. & Kataria, M. (1974) Quarterly Journal of Medicine, New Series, 28, 4961.
Pearce, J. (1974) The extrapyramidal disorders of Alzheimer's disease. European Neurology, 12, 94103.
Perry, E. K., Perry, R. H., Blessed, G. & Tomlinson, B. E. (1977) Necropsy evidence of central cholinergic deficits in senile dementia. Lancet, 1, 189.
Robinson, D. S., Davies, J. M., Nies, A., Colburn, R. W., Davis, J. N., Bourne, H. R., Bunney, W. E., Shaw, D. M. & Coppen, A. (1972) Ageing, monoamines and monoamine oxidaser levels. Lancet, i 290–1.
Spillane, J. A., White, P., Goodhardt, M. J., Flack, R. H. A., Bowen, D. M. & Davison, A. N. (1977) Selective vulnerability of neurons in organic dementia. Nature, 266, 558–9.
Terry, R. D. (1978) Ageing, senile dementia and Alzheimer's disease. In Alzheimer's Disease: Senile Dementia and Related Disorders (Ageing, vol. 7). (Eds. Terry, R. D. and Bick, K. L.). New York: Raven Press, pp 1114.
Terry, R. D. & Wisniewski, H. M. (1972) Ultrastructure of senile dementia and of experimental analogs. In Ageing and the Brain. (Ed. Gaitz, C. M.). New York: Plenum Press. pp 89116.
Tomlinson, B. E., Blessed, G. & Roth, M. (1970) Observations on the brains of demented old people. Journal of the Neurological Sciences, 11, 205–42.
White, P., Goodhardt, M. J., Keet, J. P., Hiley, C. R., Carrasco, L. H. & Williams, I. E. (1977) Neurocortical cholinergic neurons in elderly people. Lancet, 1, 669–70.
Willanger, R., Thygesen, P., Nielsen, R. & Petersen, O. (1968) Intellectual impairment and cerebral atrophy. A psychological and neuroradiological investigation. Danish Medical Bulletin, 15, 6993.
World Federation op Neurology (1959) Collaborative study of epidemiological factors in cerebral vascular disease. Coding Guide, Antwerp.
Yamada, M. & Mehraein, P. (1977) Verteilungsmuster der senilen Veränderungen in den Hirnstammkernen. Folia Psychiatrica et Neurologica Japonica, 31, 219–24.
Zis, A. P., Fibiger, H. C. & Philips, A. G. (1974) Reversal by l-dopa of impaired learning due to destruction of the dopaminergic nigro-neostriatal projection. Science, 195, 960–2.

Changes in the Brain Catecholamines in Patients with Dementia of Alzheimer Type

  • R. Adolfsson (a1), C. G. Gottfries (a2), B. E. Roos (a3) and B. Winblad (a4)

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Changes in the Brain Catecholamines in Patients with Dementia of Alzheimer Type

  • R. Adolfsson (a1), C. G. Gottfries (a2), B. E. Roos (a3) and B. Winblad (a4)
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