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Brain White-Matter Lesions and Psychosis

  • Bruce L. Miller (a1), Ira M. Lesser (a2), Kyle Boone (a2), Mark Goldberg (a1), Elizabeth Hill (a2), Milton H. Miller (a2), D. Frank Benson (a3) and Mark Mehringer (a3)...

Abstract

In a prospective study of late-life onset psychosis, five of the first 27 patients studied had extensive white-matter lesions demonstrated by MRI and/or CT. None of 60 age-matched psychiatrically healthy controls demonstrated such lesions. All five patients had a mild dementia and a frontal behavioural syndrome. In addition, every patient performed poorly on neuropsychological tests of frontal function. Dysfunction of the frontal cortex associated with white-matter lesions appears to contribute to the clinical picture of some cases of late-life psychosis.

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Harbor-UCLA Medical Center, 1000 W. Carson, Torrance, CA 90509, USA.

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Brain White-Matter Lesions and Psychosis

  • Bruce L. Miller (a1), Ira M. Lesser (a2), Kyle Boone (a2), Mark Goldberg (a1), Elizabeth Hill (a2), Milton H. Miller (a2), D. Frank Benson (a3) and Mark Mehringer (a3)...

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Brain White-Matter Lesions and Psychosis

  • Bruce L. Miller (a1), Ira M. Lesser (a2), Kyle Boone (a2), Mark Goldberg (a1), Elizabeth Hill (a2), Milton H. Miller (a2), D. Frank Benson (a3) and Mark Mehringer (a3)...
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