1Taylor, WD, Aizenstein, HJ, Alexopoulos, GS. The vascular depression hypothesis: mechanisms linking vascular disease with depression. Mol Psychiatry 2013; 18(9): 963–74.
2Alexopoulos, GS. Frontostriatal and limbic dysfunction in late-life depression. Am J Geriatr Psychiatry 2002; 10(6): 687–95.
3Almeida, OP, Burton, EJ, Ferrier, N, McKeith, IG, O'Brien, JT. Depression with late onset is associated with right frontal lobe atrophy. Psychol Med 2003; 33(4): 675–81.
4Dotson, VM, Davatzikos, C, Kraut, MA, Resnick, SM. Depressive symptoms and brain volumes in older adults: a longitudinal magnetic resonance imaging study. J Psychiatry Neurosci 2009; 34(5): 367–75.
5MacFall, JR, Payne, ME, Provenzale, JE, Krishnan, KR. Medial orbital frontal lesions in late-onset depression. Biol Psychiatry 2001; 49(9): 803–6.
6Herrmann, LL, Le Masurier, M, Ebmeier, KP. White matter hyperintensities in late life depression: a systematic review. J Neurol Neurosurg Psychiatry 2008; 79(6): 619–24.
7Nobuhara, K, Okugawa, G, Sugimoto, T, Minami, T, Tamagaki, C, Takase, K, et al. Frontal white matter anisotropy and symptom severity of late-life depression: a magnetic resonance diffusion tensor imaging study. J Neurol Neurosurg Psychiatry 2006; 77(1): 120–2.
8Kumar, A, Thomas, A, Lavretsky, H, Yue, K, Huda, A, Curran, J, et al. Frontal white matter biochemical abnormalities in late-life major depression detected with proton magnetic resonance spectroscopy. Am J Psychiatry 2002; 159(4): 630–6.
9Lai, T, Payne, ME, Byrum, CE, Steffens, DC, Krishnan, KR. Reduction of orbital frontal cortex volume in geriatric depression. Biol Psychiatry 2000; 48(10): 971–5.
10Hoffmann, M. The human frontal lobes and frontal network systems: an evolutionary, clinical, and treatment perspective. ISRN Neurol 2013; 2013: 892459.10.1155/2013/892459
11Briggs, R, Kenny, RA, Kennelly, SP. Does baseline hypotension predict incident depression in a cohort of community-dwelling older people? Data from The Irish Longitudinal Study on Ageing (TILDA). Age Ageing 2017; 46(4): 648–53.
12Briggs, R, Carey, D, Kennelly, SP, Kenny, RA. Longitudinal association between orthostatic hypotension at 30 seconds post standing and late life depression. Hypertension 2018; 71(5): 946–54.10.1161/HYPERTENSIONAHA.117.10542
13Navarro, V, Gastó, C, Lomeña, F, Mateos, JJ, Marcos, T. Frontal cerebral perfusion dysfunction in elderly late-onset major depression assessed by 99MTC-HMPAO SPECT. NeuroImage 2001; 14(1 Pt 1): 202–5.10.1006/nimg.2001.0787
14Lesser, IM, Mena, I, Boone, KB, Miller, BL, Mehringer, CM, Wohl, M. Reduction of cerebral blood flow in older depressed patients. Arch Gen Psychiatry 1994; 51(9): 677–86.
15Alosco, ML, Spitznagel, MBB, Cohen, R, Raz, N, Sweet, LH, Josephson, R, et al. Reduced cerebral perfusion predicts greater depressive symptoms and cognitive dysfunction at a 1-year follow-up in patients with heart failure. Int J Geriatr Psychiatry 2014; 29(4): 428–36.
16Strangman, G, Boas, DA, Sutton, JP. Non-invasive neuroimaging using near-infrared light. Biol Psychiatry 2002; 52(7): 679–93.
17Taussky, P, O'Neal, B, Daugherty, WP, Luke, S, Thorpe, D, Pooley, RA, et al. Validation of frontal near-infrared spectroscopy as noninvasive bedside monitoring for regional cerebral blood flow in brain-injured patients. Neurosurg Focus 2012; 32(2): E2.
18Whelan, BJ, Savva, GM. Design and methodology of the Irish Longitudinal Study on Ageing. J Am Geriatr Soc 2013; 61(Suppl 2): S265–8.10.1111/jgs.12199
19Nieuwhof, F, Reelick, MF, Maidan, I, Mirelman, A, Hausdorff, JM, Olde Rikkert, MGM, et al. Measuring prefrontal cortical activity during dual task walking in patients with Parkinson's disease: feasibility of using a new portable fNIRS device. Pilot Feasibility Stud 2016; 2: 59.10.1186/s40814-016-0099-2
20Bale, G, Elwell, CE, Tachtsidis, I. From Jöbsis to the present day: a review of clinical near-infrared spectroscopy measurements of cerebral cytochrome-c-oxidase. J Biomed Opt 2016; 21(9): 091307.10.1117/1.JBO.21.9.091307
21Colier, WN, Binkhorst, RA, Hopman, MT, Oeseburg, B. Cerebral and circulatory haemodynamics before vasovagal syncope induced by orthostatic stress. Clin Physiol 1997; 17(1): 83–94.
22Jones, S, Chiesa, ST, Chaturvedi, N, Hughes, AD. Recent developments in near-infrared spectroscopy (NIRS) for the assessment of local skeletal muscle microvascular function and capacity to utilise oxygen. Artery Res 2016; 16: 25–33.
23Finucane, C, O'Connell, MD, Fan, CWW, Savva, GM, Soraghan, CJ, Nolan, H, et al. Age-related normative changes in phasic orthostatic blood pressure in a large population study: findings from The Irish Longitudinal Study on Ageing (TILDA). Circulation 2014; 130(20): 1780–9.
24Freeman, R, Wieling, W, Axelrod, FB, Benditt, DG, Benarroch, E, Biaggioni, I, et al. Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res 2011; 21(2): 69–72.
25Briggs, R, Carey, D, O'Halloran, A, Kenny, RA, Kennelly, SP. Validation of the 8-item Centre for Epidemiological Studies Depression Scale in a cohort of community-dwelling older people: data from The Irish Longitudinal Study on Ageing (TILDA). Eur Geriatr Med 2018; 9: 121–126.
26O'Halloran AM, K, King-Kallimanis BL, RA. The latent factors of depression from the short forms of the CES-D are consistent, reliable and valid in community-living older adults. Eur Geriatr Med 2014; 5(2): 97–102.10.1016/j.eurger.2013.12.004
27Bachus, E, Holm, H, Hamrefors, V, Melander, O, Sutton, R, Magnusson, M, et al. Monitoring of cerebral oximetry during head-up tilt test in adults with history of syncope and orthostatic intolerance. Europace 2018; 20(9): 1535–42.
28Rosenbaum, D, Hagen, K, Deppermann, S, Kroczek, AM, Haeussinger, FB, Heinzel, S, et al. State-dependent altered connectivity in late-life depression: a functional near-infrared spectroscopy study. Neurobiolf Aging 2016; 39: 57–68.10.1016/j.neurobiolaging.2015.11.022
29Ma, X-Y, Wang, Y-J, Xu, B, Feng, K, Sun, GX, Zhang, XQ, et al. Near-infrared spectroscopy reveals abnormal hemodynamics in the left dorsolateral prefrontal cortex of menopausal depression patients. Dis Markers 2017; 2017: 1695930.
30Abi Zeid Daou, M, Boyd, BD, Donahue, MJ, Albert, K, Taylor, WD. Frontocingulate cerebral blood flow and cerebrovascular reactivity associated with antidepressant response in late-life depression. J Affect Disord 2017; 215: 103–10.
31Navarro, V, Gastó, C, Lomeña, F, Torres, X, Mateos, JJ, Portella, MJ, et al. Prognostic value of frontal functional neuroimaging in late-onset severe major depression. Br J Psychiatry 2004; 184(4): 306–11.
32Brickman, AM, Zahra, A, Muraskin, J, Steffener, J, Holland, CM, Habeck, C, et al. Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging. Psychiatry Res 2009; 172(2): 117–20.
33Briggs, R, Kennelly, SP, Kenny, RAA. Does baseline depression increase the risk of unexplained and accidental falls in a cohort of community-dwelling older people? Data from The Irish Longitudinal Study on Ageing (TILDA). Int J Geriatr Psychiatry 2018; 33(2): e205–11.
34Mozolic, JL, Hayasaka, S, Laurienti, PJ. A cognitive training intervention increases resting cerebral blood flow in healthy older adults. Front Hum Neurosci 2010; 4: 16.
35Penninx, BW, Rejeski, WJ, Pandya, J, Miller, ME, Di Bari, M, Applegate, WB, et al. Exercise and depressive symptoms: a comparison of aerobic and resistance exercise effects on emotional and physical function in older persons with high and low depressive symptomatology. J Gerontol B Psychol Sci Soc Sci 2002; 57(2): P124–32.