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The Scottish First Episode Schizophrenia Study V. One-year Follow-up

The Scottish Schizophrenia Research Group

Published online by Cambridge University Press:  02 January 2018

Robin G. McCreadie
Affiliation:
Gartloch Hospital, Gartcosh, Glasgow G69 8EJ
David H. Wiles
Affiliation:
Gartloch Hospital, Gartcosh, Glasgow G69 8EJ
Stewart M. Grant
Affiliation:
Gartloch Hospital, Gartcosh, Glasgow G69 8EJ
John W. Moore
Affiliation:
Gartloch Hospital, Gartcosh, Glasgow G69 8EJ
Zahid Mahmood
Affiliation:
Top Grade Psychologist Gartnavel Royal Hospital, Glasgow G12 0YN
Martin G. Livingston
Affiliation:
Glasgow G53 7TU
James A. G. Watt
Affiliation:
Glasgow G53 7TU
J. G. Greene
Affiliation:
Glasgow G53 7TU
Peter W. Kershaw
Affiliation:
Glasgow G53 7TU
Norman A. Todd
Affiliation:
Royal Edinburgh Hospital, Edinburgh EH10 5HF
Angus M. Scott
Affiliation:
Royal Edinburgh Hospital, Edinburgh EH10 5HF
John Loudon
Affiliation:
Janssen Pharmaceutical Limited, Grove, Wantage, Oxon
James A. T. Dyer
Affiliation:
Janssen Pharmaceutical Limited, Grove, Wantage, Oxon
Alistair E. Philip
Affiliation:
Janssen Pharmaceutical Limited, Grove, Wantage, Oxon

Abstract

Of 49 schizophrenic patients followed up 12 months after their first admission to hospital, only about 45% had experienced no relapse and had no schizophrenic symptoms; a poorer outcome was more often found in Feighner positive than Feighner negative schizophrenic patients. The patients' overall level of unemployment had more than doubled to 51%. In patients whose acute episodes responded to treatment, pimozide taken once weekly as maintenance therapy was as effective as intramuscular flupenthixol decanoate, but tardive dyskinesia appeared in two patients receiving weekly pimozide; the repeat psychometric assessment at 12 months found modest improvements, i.e. no evidence of intellectual decline, in Matrices, Block Design, and Digit Copying tests. Forty per cent of relatives still showed significant psychological distress, which correlated with patients' schizophrenic symptoms, and the relatives' social functioning remained poorer than that of a normal community sample.

Type
Research Article
Copyright
Copyright © Royal College of Psychiatrists, 1988 

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References

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