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Facial Affect Recognition in Myasthenia Gravis

  • Esther Lázaro (a1), Imanol Amayra (a1), Juan Francisco López-Paz (a1), Amaia Jometón (a1), Natalia Martín (a2), Patricia Caballero (a1), Luís De Nicolás (a1), Holger Hoffmann (a3), Henrik Kessler (a3), Begoña Ruiz (a4) and Oscar Martínez (a1)...

Abstract

The assessment of facial expression is an important aspect of a clinical neurological examination, both as an indicator of a mood disorder and as a sign of neurological damage. To date, although studies have been conducted on certain psychosocial aspects of myasthenia, such as quality of life and anxiety, and on neuropsychological aspects such as memory, no studies have directly assessed facial emotion recognition accuracy. The aim of this study was to assess the facial emotion recognition accuracy (fear, surprise, sadness, happiness, anger, and disgust), empathy, and reaction time of patients with myasthenia. Thirty-five patients with myasthenia and 36 healthy controls were tested for their ability to differentiate emotional facial expressions. Participants were matched with respect to age, gender, and education level. Their ability to differentiate emotional facial expressions was evaluated using the computer-based program Feel Test. The data showed that myasthenic patients scored significantly lower (p < 0.05) than healthy controls in the total Feel score, fear, surprise, and higher reaction time. The findings suggest that the ability to recognize facial affect may be reduced in individuals with myasthenia.

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Corresponding author

*Corresponding author: Esther Lázaro, Universidad de Deusto (Spain), E-mail: estherlazaro@deusto.es

References

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Adolphs, R., Damasio, H., Tranel, D., Cooper, G., & Damasio, A. (2000). A role for somatosensory cortices in the visual recognition of emotion as revealed by three dimensional lesion mapping. Journal of Neuroscience, 20, 16831690.
Adolphs, R., Gosselin, F., Buchannan, T., Tranel, D., Schyns, P., & Damasio, A. (2005). A mechanism for impaired fear recognition after amygdala damage. Nature, 433, 6872. http://dx.doi.org/10.1038/nature03086
Aviezer, H., Bentin, S., Hassin, R., Meshino, W., Kennedy, J., Grewal, S., … & Moskovitch, M. (2009). Not on the face alone: Perception of contextualized face expressions in Huntington´s disease. Brain, 132, 16331644. http://dx.doi.org/10.1093/brain/awp067
Bartel, P., & Lotz, B. (1995). Neuropsychological test performance and affect in myasthenia gravis. Acta Neurologica Scandinavica, 91, 266270. http://dx.doi.org/10.1111/j.1600-0404.1995.tb07002.x
Clader, J., & Wang, Y. (2005). Muscarinic receptor agonists and antagonists in the treatment of Alzheimer’s disease. Current Pharmaceutical Design, 11, 33533361. http://dx.doi.org/10.2174/138161205774370762
Cohen, J. (1962). The statistical power of abnormal-social psychological research: A review. Journal of abnormal and social psychology, 65, 145153. http://dx.doi.org/10.1037/h0045186
Davis, M. (1908). A multidimensional approach to individuals differences in empathy. JSAS Catalog of Selected Documents in Psychology, 10, 85103.
Denham, S. (1998). Emotional development in young children. New York, NY: Guilford Press.
Ekman, P. (1993). Facial expression and emotion. American Psychologist, 48, 384392. http://dx.doi.org/10.1037//0003-066X.48.4.384
Graef, S., Schönknecht, P., Sabri, O., & Hegerl, U. (2011). Cholinergic receptor subtypes and their role in cognition, emotion, and vigilance control: An overview of preclinical and clinical findings. Psychopharmacology, 215, 205229. http://dx.doi.org/10.1007/s00213-010-2153-8
Grey, J., Young, A., Barker, W., Curtis, A., & Gibson, D. (1997). Impaired recognition of disgust in Huntington´s disease gene carriers. Brain, 120, 20292038. http://dx.doi.org/10.1093/brain/120.11.2029
Halberstadt, J., Winkielman, P., Niedenthal, P., & Dalle, N. (2009). Emotional conception. How embodied concepts guide perception and facial action. Psychological Science, 20, 12541261. http://dx.doi.org/10.1111/j.1467-9280.2009.02432.x
Hinton, V., Fee, R., De Vivo, D., & Goldstein, E. (2007). Poor facial affect recognition among boys with Duchenne muscular dystrophy. Journal of Autism Developmental Disorders, 37, 19251933. http://dx.doi.org/10.1007/s10803-006-0325-5
Hoffmann, H. (2010). Expression intensity, gender and facial emotion recognition: Women recognize only subtle facial emotions better than men. Acta Psychologica, 135, 278283. http://dx.doi.org/10.1016/j.actpsy.2010.07.012
Jehna, M., Neuper, C., Petrovic, K., Wallner-Blazek, M., Schmidt, R., Fuchs, S., … Enzinger, C. (2010). An exploratory study on emotion recognition in patients with a clinically isolated syndrome and multiple sclerosis. Clinical Neurology and Neurosurgery, 112, 482484. http://dx.doi.org/10.1016/j.clineuro.2010.03.020
Kamboj, S., & Curran, H. (2006a). Scopolamine induces impairments in the recognition of human facial expressions of anger and disgust. Psychopharmacology, 185, 529535. http://dx.doi.org/10.1007/s00213-006-0332-4
Kamboj, S., & Curran, H. (2006b). Neutral and emotional episodic memory: Global impairment after lorazepam or scopolamine. Psychopharmacology, 188, 482488. http://dx.doi.org/10.1007/s00213-006-0552-7
Keesey, J. (1999). Does myasthenia gravis affect the brain? Journal of Neurological Science, 170, 7789. http://dx.doi.org/10.1016/S0022-510X(99)00205-1
Kessler, H., Bayerl, P., Deighton, R., & Traue, H. (2002). Facially Expressed Emotion Labelling (FEEL): PC-gestützter Test zur Emotionserkennung. [Facially Expressed Emotion Labeling (FEEL): A computer test for emotion recognition]. Verhaltenstherapie und Verhaltensmedizin, 23, 297306.
Kipps, C., Duggins, A., McCusker, E., & Calder, A. (2007). Disgust and happiness recognition correlate with anteroventral insula and amygdala volume respectively in preclinical Huntington’s disease. Journal of Cognitive Neuroscience, 19, 12061217. http://dx.doi.org/10.1162/jocn.2007.19.7.1206
Kobayakawa, M., Tsuruya, N., Takeda, A., Suzuki, A., & Kawamura, M. (2010). Facial emotion recognition and cerebral white matter lesions in myotonic dystrophy type 1. Journal of the Neurological Sciences, 290, 4851. http://dx.doi.org/10.1016/j.jns.2009.11.011
Kojevnikov, A. (1986). Some aspects of myasthenia gravis. Annals of the New York Academy of Sciences, 135, 406.
Kuks, J., & Oosterhuis, H. (2003). Clinical presentation and epidemiology of myasthenia gravis. In Kaminski, H (Ed.), Current clinical neurology: Myasthenia gravis and related disorders (pp. 93113). Totowa, NJ: Human Press.
LeDoux, J. (2007). The amygdala. Current Biology, 17, 868874. http://dx.doi.org/10.1016/j.cub.2007.08.005
Levin, E., MecClernon, J., & Rezvani, A. (2006). Nicotinic effects on cognitive function: Behavioral characterization, pharmacological specification, and anatomic localization. Psychopharmacology, 184, 523539. http://dx.doi.org/10.1007/s00213-005-0164-7
Lindquist, K., Wager, T., Kober, H., Bliss-Moreau, E., & Feldman, L. (2012). The brain basis of emotion: A meta-analytic review. Behavioral and Brain Sciences, 35, 121143. http://dx.doi.org/10.1017/S0140525X11000446
Mao, Z., Mo, X., Qin, C., Lai, Y., & olde Hartman, T. (2010). Course and prognosis of myasthenia gravis: A systematic review. European Journal of Neurology, 17, 913921. http://dx.doi.org/10.1111/j.1468-1331.2010.03017.x
Matsumoto, D., & Ekman, P. (1988). Japanese and Caucasian facial expressions of emotion (IACFEE) [Slides]. San Francisco, CA: Intercultural and Emotion Research Laboratory, Department of Psychology, San Francisco State University.
Mazzola, F., Seigal, A., MacAskill, A., Corden, B., Lawrence, K., & Skuse, D. (2006). Eye tracking and fear recognition deficits in Turner syndrome. Social Neuroscience, 1, 259–169. http://dx.doi.org/10.1080/17470910600989912
McLellan, T., Johnson, L., Dalrymple-Alford, J., & Poeter, R. (2008). The recognition of facial expressions of emotion in Alzheimer´s disease: A review of findings. Acta Neuropsychiatrica, 20, 236250. http://dx.doi.org/10.1111/j.1601-5215.2008.00315.x
Meriggioli, M., & Sanders, D. (2009). Autoimmune myasthenia gravis: Emerging clinical and biological heterogeneity. Lancet Neurology, 8, 475490. http://dx.doi.org/10.1016/S1474-4422(09)70063-8
Mesulam, M. (2004). The cholinergic lesion of Alzheimer´s disease: Pivotal factor or side show? Learning and Memory, 11, 4349. http://dx.doi.org/10.1101/lm.69204
Miwa, J., Freedman, R., & Lester, H. (2011). Neural systems governed by nicotinic acetylcholine receptors: Emerging hypotheses. Neuron, 70, 2033. http://dx.doi.org/10.1016/j.neuron.2011.03.014
Osserman, K. (1958). Myasthenia gravis. New York, NY: Grune and Stratton.
Pérez-Albéniz, A., Paúl, J., Montes, M. P., & Torres, E. (2003). Adaptación de Interpersonal Reactivity Index (IRI) al español. [Validation of the Spanish version of the Interpersonal Reactivity Index]. Psicothema, 15, 267272.
Philips, L. (2003). The epidemiology of myasthenia gravis. Annals of the New York Academy of Sciences, 998, 407412. http://dx.doi.org/10.1196/annals.1254.053
Posamienter, M., & Abdi, H. (2003). Processing faces and facial expressions. Neuropsychology Review, 13, 113143.
Sitek, W., Bilinska, M., Wieczorek, D., & Nyka, W. (2009). Neuropsychological assessment in myasthenia gravis. Neurological Sciences, 30, 914. http://dx.doi.org/10.1007/s10072-008-0001-y
Sprengelmeyer, R., Young, A., Sprengelmeyer, A., Calder, A., Rowland, D., Perrett, D., … Lange, H. (1997). Recognition of facial expression: Selective impairment of specific emotions in Huntington´s disease. Cognitive Neuropsychology, 14, 839879. http://dx.doi.org/10.1080/026432997381376
Thomsen, M., Hansen, H., Timmerman, D., & Mikkelsen, J. (2010). Cognitive improvement by activation of α7 nicotinic acetylcholine receptors: From animal models to human pathophysiology. Current Pharmaceutical Design, 16, 323343. http://dx.doi.org/10.2174/138161210790170094
Tucker, D., Roeltgen, D., Wann, P., & Wertheimer, R. (1988). Memory dysfunction in myasthenia gravis: Evidence for central cholinergic effects. Neurology, 38, 11731177. http://dx.doi.org/10.1212/WNL.38.8.1173
Ybarra, M., Kummer, A., Comini, E., Oliveira, J., Gómez, R., & Texeira, A. (2011). Psychiatric Disorders in myasthenia gravis. Arquivos de Neuro-Psiquiatría, 69, 176179. http://dx.doi.org/10.1590/S0004-282X2011000200006
Whittington, J., & Holland, T. (2011). Recognition of emotion in facial expression by people with Prader-Willi syndrome. Journal of Intellectual Disability Research, 55, 7584. http://dx.doi.org/10.1111/j.1365-2788.2010.01348.x
Winblad, S., Hellström, P., Lindberg, C., & Hansen, S. (2006). Facial emotion recognition in myotonic dystrophy type 1 correlates with CTG repeat expansion. Journal of Neurological, Neurosurgery and Psychiatry, 77, 219223. http://dx.doi.org/10.1136/jnnp.2005.070763.

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