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Prevalence of thyroid dysfunction with adequate and excessive iodine intake in Hebei Province, People’s Republic of China

  • Long Tan (a1), Zhongna Sang (a1), Jun Shen (a2), Hua Liu (a3), Wen Chen (a1), Na Zhao (a1), Wei Wei (a4), Guiqin Zhang (a5) and Wanqi Zhang (a1)...

Abstract

Objective

To explore (i) the prevalence of thyroid dysfunction in populations with adequate and excessive iodine intakes and (ii) the effect of iodine exposure on the prevalence of thyroid dysfunction.

Design

Cross-sectional study was conducted in Hebei in 2010. The population was classified as having adequate or excessive iodine intake according to the iodine concentration in drinking water. Demographic information was collected by questionnaire. Levels of serum thyroid hormones, thyroid autoantibodies and iodine in drinking water and urine were measured.

Setting

Villages with adequate or excessive drinking water iodine in Hebei Province, People’s Republic of China.

Subjects

A total of 854 men and women aged 20–50 years who had lived in the surveyed areas for over 5 years, including 348 from the adequate iodine area (AIA) and 506 from the excessive iodine area (EIA).

Results

Median urinary iodine concentration was 185 μg/l in AIA and 1152 μg/l in EIA. The prevalence of thyroid dysfunction in AIA was 10·3 %, which included 1·1 % with hypothyroidism and 8·1 % with subclinical hypothyroidism; and 20·6 % in EIA, which included 3·6 % with hypothyroidism and 13·6 % with subclinical hypothyroidism. The positive rates of thyroglobulin antibody were 16·1 % in AIA and 11·9 % in EIA; the positive rates of thyroperoxidase antibody were 20·7 % in AIA and 16·4 % in EIA.

Conclusions

Excessive iodine intake may lead to increased prevalence of biochemical thyroid dysfunction, especially biochemical hypothyroidism. This is not related to an increase in prevalence of thyroid antibodies. Women are more susceptible to iodine excess.

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Copyright

Corresponding author

* Corresponding author: Email wqzhang@tijmu.edu.cn

References

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Keywords

Prevalence of thyroid dysfunction with adequate and excessive iodine intake in Hebei Province, People’s Republic of China

  • Long Tan (a1), Zhongna Sang (a1), Jun Shen (a2), Hua Liu (a3), Wen Chen (a1), Na Zhao (a1), Wei Wei (a4), Guiqin Zhang (a5) and Wanqi Zhang (a1)...

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