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Pre-pregnancy obesity and maternal nutritional biomarker status during pregnancy: a factor analysis

  • Laura E Tomedi (a1), Chung-Chou H Chang (a2), PK Newby (a3) (a4) (a5), Rhobert W Evans (a1), James F Luther (a1), Katherine L Wisner (a1) (a6) (a7) and Lisa M Bodnar (a1) (a6) (a7)...

Abstract

Objective

Pre-pregnancy obesity has been associated with adverse birth outcomes. Poor essential fatty acid (EFA) and micronutrient status during pregnancy may contribute to these associations. We assessed the associations between pre-pregnancy BMI and nutritional patterns of maternal micronutrient and EFA status during mid-pregnancy.

Design

A cross-sectional analysis from a prospective cohort study. Women provided non-fasting blood samples at ≤20 weeks’ gestation that were assayed for red cell EFA; plasma folate, homocysteine and ascorbic acid; and serum retinol, 25-hydroxyvitamin D, α-tocopherol, soluble transferrin receptors and carotenoids. These nutritional biomarkers were employed in a factor analysis and three patterns were derived: EFA, Micronutrients and Carotenoids.

Setting

The Antidepressant Use During Pregnancy Study, Pittsburgh, PA, USA.

Subjects

Pregnant women (n 129).

Results

After adjustment for parity, race/ethnicity and age, obese pregnant women were 3·0 (95 % CI 1·1, 7·7) times more likely to be in the lowest tertile of the EFA pattern and 4·5 (95 % CI 1·7, 12·3) times more likely to be in the lowest tertile of the Carotenoid pattern compared with their lean counterparts. We found no association between pre-pregnancy obesity and the Micronutrient pattern after confounder adjustment.

Conclusions

Our results suggest that obese pregnant women have diminished EFA and carotenoid concentrations.

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Copyright

Corresponding author

*Corresponding author: Email bodnar@edc.pitt.edu

References

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Pre-pregnancy obesity and maternal nutritional biomarker status during pregnancy: a factor analysis

  • Laura E Tomedi (a1), Chung-Chou H Chang (a2), PK Newby (a3) (a4) (a5), Rhobert W Evans (a1), James F Luther (a1), Katherine L Wisner (a1) (a6) (a7) and Lisa M Bodnar (a1) (a6) (a7)...

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