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Physical impairment and body weight history in postmenopausal women: the Women’s Health Initiative

  • Amal A Wanigatunga (a1) (a2), Sandrine S Sourdet (a3), Michael J LaMonte (a4), Molly E Waring (a5) (a6), Rami Nassir (a7), Lorena Garcia (a8), Jennifer W Bea (a9), Rebecca A Seguin (a10), Judith K Ockene (a11), Gloria E Sarto (a12), Marcia L Stefanick (a13), Marian Limacher (a14), Todd M Manini (a2) and for the Women’s Health Initiative Investigators...

Abstract

Objective

To examine whether weight history and weight transitions over adult lifespan contribute to physical impairment among postmenopausal women.

Design

BMI categories were calculated among postmenopausal women who reported their weight and height at age 18 years. Multiple-variable logistic regression was used to determine the association between BMI at age 18 years and BMI transitions over adulthood on severe physical impairment (SPI), defined as scoring <60 on the Physical Functioning subscale of the Rand thirty-six-item Short-Form Health Survey.

Setting

Participants were part of the Women’s Health Initiative Observational Study (WHI OS), where participants’ health was followed over time via questionnaires and clinical assessments.

Subjects

Postmenopausal women (n 76 016; mean age 63·5 (sd 7·3) years).

Results

Women with overweight (BMI=25·0–29·9 kg/m2) or obesity (BMI≥30·0 kg/m2) at 18 years had greater odds (OR (95 % CI)) of SPI (1·51 (1·35, 1·69) and 2·14 (1·72, 2·65), respectively) than normal-weight (BMI=18·5–24·9 kg/m2) counterparts. Transitions from normal weight to overweight/obese or to underweight (BMI<18·5 kg/m2) were associated with greater odds of SPI (1·97 (1·84, 2·11) and 1·35 (1·06, 1·71), respectively) compared with weight stability. Shifting from underweight to overweight/obese also had increased odds of SPI (1·52 (1·11, 2·09)). Overweight/obese to normal BMI transitions resulted in a reduced SPI odds (0·52 (0·39, 0·71)).

Conclusions

Higher weight history and transitions into higher weight classes were associated with higher likelihood of SPI, while transitioning into lower weight classes for those with overweight/obesity was protective among postmenopausal women.

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Copyright

Corresponding author

* Corresponding author: Email asiri@ufl.edu

References

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1. Ogden, CL, Carroll, MD, Kit, BK et al. (2014) Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA 311, 806814.
2. Aronne, LJ (2001) Epidemiology, morbidity, and treatment of overweight and obesity. J Clin Psychiatry 62, Suppl. 23, 1322.
3. Villareal, DT, Apovian, CM, Kushner, RF et al. (2005) Obesity in older adults: technical review and position statement of the American Society for Nutrition and NAASO, The Obesity Society. Obes Res 13, 18491863.
4. Runhaar, J, Koes, BW, Clockaerts, S et al. (2011) A systematic review on changed biomechanics of lower extremities in obese individuals: a possible role in development of osteoarthritis. Obes Rev 12, 10711082.
5. Furukawa, S, Fujita, T, Shimabukuro, M et al. (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114, 17521761.
6. Brinkley, TE, Hsu, FC, Beavers, KM et al. (2012) Total and abdominal adiposity are associated with inflammation in older adults using a factor analysis approach. J Gerontol A Biol Sci Med Sci 67, 10991106.
7. Stenholm, S, Koster, A, Alley, DE et al. (2010) Joint association of obesity and metabolic syndrome with incident mobility limitation in older men and women – results from the Health, Aging, and Body Composition Study. J Gerontol A Biol Sci Med Sci 65, 8492.
8. Beavers, KM, Miller, ME, Rejeski, WJ et al. (2013) Fat mass loss predicts gain in physical function with intentional weight loss in older adults. J Gerontol A Biol Sci Med Sci 68, 8086.
9. Hubert, HB, Feinleib, M, McNamara, PM et al. (1983) Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation 67, 968977.
10. Faith, MS, Matz, PE & Jorge, MA (2002) Obesity–depression associations in the population. J Psychosom Res 53, 935942.
11. Ford, ES, Williamson, DF & Liu, S (1997) Weight change and diabetes incidence: findings from a national cohort of US adults. Am J Epidemiol 146, 214222.
12. Flegal, KM, Carroll, MD, Ogden, CL et al. (2010) Prevalence and trends in obesity among US adults, 1999–2008. JAMA 303, 235241.
13. Flegal, KM, Carroll, MD, Kit, BD et al. (2012) Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999–2010. JAMA 307, 491497.
14. Backholer, K, Pasupathi, K, Wong, E et al. (2012) The relationship between body mass index prior to old age and disability in old age. Int J Obes Relat Metab Disord 36, 11801186.
15. Houston, DK, Stevens, J, Cai, J et al. (2005) Role of weight history on functional limitations and disability in late adulthood: the ARIC study. Obes Res 13, 17931802.
16. Peeters, A, Bonneux, L, Nusselder, WJ et al. (2004) Adult obesity and the burden of disability throughout life. Obes Res 12, 11451151.
17. Williams, ED, Eastwood, SV, Tillin, T et al. (2014) The effects of weight and physical activity change over 20 years on later-life objective and self-reported disability. Int J Epidemiol 43, 856865.
18. Launer, L, Harris, T, Rumpel, C et al. (1994) Body mass index, weight change, and risk of mobility disability in middle-aged and older women. The epidemiologic follow-up study of NHANES I. JAMA 271, 10931098.
19. Stenholm, S, Sallinen, J, Koster, A et al. (2011) Association between obesity history and hand grip strength in older adults – exploring the roles of inflammation and insulin resistance as mediating factors. J Gerontol A Biol Sci Med Sci 66, 341348.
20. Hung, WW, Ross, JS, Boockvar, KS et al. (2011) Recent trends in chronic disease, impairment and disability among older adults in the United States. BMC Geriatr 11, 47.
21. Murtagh, KN & Hubert, HB (2004) Gender differences in physical disability among an elderly cohort. Am J Public Health 94, 14061411.
22. Bouchard, DR, Senechal, M, Slaught, J et al. (2013) Obesity history affects health profile and physical capacity of postmenopausal obese women; a pilot study. J Res Obes 2013, e1e12.
23. The Women’s Health Initiative Study Group (1998) Design of the Women’s Health Initiative clinical trial and observational study. Control Clin Trials 19, 61109.
24. Ware, JE & Sherbourne, CD (1992) The MOS 36-ltem Short-Form Health Survey (SF-36). Med Care 30, 473483.
25. Bohannon, RW & Depasquale, L (2010) Physical Functioning Scale of the Short-Form (SF) 36: internal consistency and validity with older adults. J Geriatr Phys Ther 33, 1618.
26. Patterson, RE, Kristal, AR, Tinker, LF et al. (1999) Measurement characteristics of the Women’s Health Initiative food frequency questionnaire. Ann Epidemiol 9, 178187.
27. Houston, DK, Ding, J, Nicklas, BJ et al. (2007) The association between weight history and physical performance in the Health, Aging and Body Composition study. Int J Obes (Lond) 31, 16801687.
28. Strandberg, TE, Strandberg, A, Salomaa, VV et al. (2003) Impact of midlife weight change on mortality and quality of life in old age. Prospective cohort study. Int J Obes Relat Metab Disord 27, 950954.
29. Fine, JT, Colditz, GA, Coakley, EH et al. (1999) A prospective study of weight change and health-related quality of life in women. JAMA 282, 2136.
30. Marton, KI, Harold, CS & Krupp, JR (1981) Involuntary weight loss: diagnostic and prognostic significance. Ann Intern Med 95, 568574.
31. Hart, DJ & Spector, TD (1993) The relationship of obesity, fat distribution and osteoarthritis in women in the general population: the Chingford Study. J Rheumatol 20, 331335.
32. Hills, AP, Hennig, EM, Byrne, NM et al. (2002) The biomechanics of adiposity–structural and functional limitations of obesity and implications for movement. Obes Rev 3, 3543.
33. Nass, D, Henning, EM & Van Treek, R (1999) The thickness of the heel pad loaded by bodyweight in obese and normal weight adults. Women 1999, 6.
34. Hills, AP, Hennig, EM, McDonald, M et al. (2001) Plantar pressure differences between obese and non-obese adults: a biomechanical analysis. Int J Obes Relat Metab Disord 25, 16741679.
35. Dowling, AM, Steele, JR & Baur, LA (2001) Does obesity influence foot structure and plantar pressure patterns in prepubescent children? Int J Obes Relat Metab Disord 25, 845852.
36. Després, JP (1997) Dyslipidaemia and obesity. Baillieres Clin Endocrinol Metab 8, 629660.
37. Sinclair, AJ, Conroy, SP & Bayer, AJ (2008) Impact of diabetes on physical function in older people. Diabetes Care 31, 233235.
38. Boughner, R (2010) Volunteer bias. In Encyclopedia of Research Design, pp. 16091611 [NJ Salkind, editor]. Thousand Oaks, CA: SAGE Publications, Inc.
39. Stewart, AL (1982) The reliability and validity of self-reported weight and height. J Chronic Dis 35, 295309.
40. Sutin, AR (2013) Optimism, pessimism, and bias in self-reported body weight among older adults. Obesity (Silver Spring) 21, E508E511.
41. Stunkard, AJ & Albaum, JM (1981) The accuracy of self-reported weights. Am J Clin Nutr 34, 15931599.
42. Perry, GS, Byers, TE, Mokdad, AH et al. (1995) The validity of self-reports of past body weights by US adults. Epidemiology 6, 6166.
43. Stevens, J, Keil, JE, Waid, LR et al. (1990) Accuracy of current, 4-year, and 28-year self-reported body weight in an elderly population. Am J Epidemiol 132, 11561163.

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