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Distribution characteristics of circulating homocysteine and folate and related factors in agriculture, stock-raising and urban populations: a cross-sectional survey

  • Fengyu Pan (a1), Mulalibieke Heizhati (a1), Lin Wang (a1), Ling Zhou (a1), Jing Hong (a1), Delian Zhang (a1), Guijuan Chang (a1), Qin Luo (a1), Le Sun (a1), Na Yue (a1) and Nanfang Li (a1)...

Abstract

Objective:

To investigate homocysteine (Hcy) and folate levels, prevalence of hyperhomocysteinaemia (HHcy) and folate deficiency, which are affected by lifestyles in urban, agricultural and stock-raising populations.

Design:

This is a cross-sectional study.

Setting:

Urban, agricultural and stock-raising regions in Emin, China.

Participants:

Totally 1926 subjects – 885 (45·9 %) from urban, 861 (44·7 %) from agricultural and 180 (9·4 %) from stock-raising regions – were obtained using multistage stratified random sampling. Inclusion criteria encompassed inhabitants aged ≥15 years who resided at the current address for ≥6 months and agreed to participate in the study. Surveys on health behaviour questionnaires and physical examinations were conducted and blood samples collected.

Results:

The folate level of subjects from the stock-raising region was the lowest, followed by those from the agricultural region, and the highest in those from the urban region (3·48 v. 6·50 v. 7·12 ng/ml, P < 0·001), whereas mean Hcy showed no significant difference across regions. The OR for HHcy in stock-raising regions was 1·90 (95 % CI 1·11, 3·27) compared with the urban region after adjusting for all possible covariates. The OR for folate deficiency in stock-raising and agriculture regions was 11·51 (95 % CI 7·09, 18·67) and 1·91 (95 % CI 1·30, 2·82), respectively, compared with the urban region after adjusting for all possible covariates.

Conclusions:

HHcy and folate deficiency are highly prevalent in stock-raisers, which is of important reference for HHcy control in Xinjiang, with a possibility of extension to others with approximate lifestyles.

Copyright

Corresponding author

*Corresponding author: Email lnanfang2016@sina.com

Footnotes

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These authors equally contributed to this work.

Footnotes

References

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Distribution characteristics of circulating homocysteine and folate and related factors in agriculture, stock-raising and urban populations: a cross-sectional survey

  • Fengyu Pan (a1), Mulalibieke Heizhati (a1), Lin Wang (a1), Ling Zhou (a1), Jing Hong (a1), Delian Zhang (a1), Guijuan Chang (a1), Qin Luo (a1), Le Sun (a1), Na Yue (a1) and Nanfang Li (a1)...

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