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Association between serum vitamin D and depressive symptoms in apparently healthy male adults undergoing routine health check-ups at a single centre

Published online by Cambridge University Press:  02 June 2020

Sung Hoon Kim
Affiliation:
Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea
Hae Jeong Lee
Affiliation:
Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea
Chang Ho Chae
Affiliation:
Department of Occupational and Environmental Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea
Seung Hyun Park
Affiliation:
Department of Occupational and Environmental Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea
Jun Seok Son
Affiliation:
Department of Occupational and Environmental Medicine, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea
Corresponding
E-mail address:

Abstract

Objective:

To determine the level of vitamin D and to identify the association between vitamin D and depressive symptoms in apparently healthy Korean male adults.

Design:

A retrospective study design. Among 43 513 participants between 1 March and 30 November 2018, after eliminating participants with a history of depression or vitamin D deficiency, 9058 were included. To determine the level of vitamin D, serum 25-hydroxyvitamin D [25(OH)D] was measured. To assess the level of depression, the Korean version of the Center for Epidemiologic Studies Depression Scale (CES-D) was used.

Setting:

South Korea.

Participants:

Male adults who underwent routine health check-ups.

Results:

The average vitamin D level was 22·31 ± 7·09 ng/ml as 25(OH)D, while the number of subjects in the vitamin D insufficiency group with a finding of <20 ng/ml was 3783 (41·8 %). The mean CES-D score in all subjects was 8·31 ± 5·97 points, and the proportion of the depressive symptoms group with a score of ≥16 was 8·71 %. The OR of patients in the depressive symptoms group also being in the insufficiency group was found to be 1·49 (95 % CI 1·12, 2·00).

Conclusions:

A total of 41·8 % of apparently healthy male adults had vitamin D levels <20 ng/ml. We identified an association between vitamin D insufficiency and depressive symptoms in apparently healthy Korean male adults.

Type
Research paper
Copyright
© The Authors 2020

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Footnotes

S.H. Kim and H.J. Lee equally contributed to this study.

References

Bivona, G, Agnello, L, Bellia, Cet al. (2019) Non-skeletal activities of vitamin D: from physiology to brain pathology. Medicina 55, pii: E341.CrossRefGoogle ScholarPubMed
Samuel, S & Sitrin, MD (2008) Vitamin D’s role in cell proliferation and differentiation. Nutr Rev 66, S116124.CrossRefGoogle ScholarPubMed
Cantorna, MT, Snyder, L, Lin, YDet al. (2015) Vitamin D and 1,25(OH)2D regulation of T cells. Nutrients 22, 3011–21.CrossRefGoogle Scholar
Skrajnowska, D & Bobrowska-Korczak, B (2019) Potential molecular mechanisms of the anti-cancer activity of vitamin D. Anticancer Res 39, 33533363.CrossRefGoogle ScholarPubMed
Domingues-Faria, C, Boirie, Y & Walrand, S (2017) Vitamin D and muscle trophicity. Curr Opin Clin Nutr Metab Care 20, 169174.CrossRefGoogle ScholarPubMed
Forman, JP, Giovannucci, E, Holmes, MDet al. (2007) Plasma 25-hydroxyvitamin D levels and risk of incident hypertension. Hypertension 49, 10631069.CrossRefGoogle ScholarPubMed
Pittas, AG, Lau, J, Hu, FBet al. (2007) The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 92, 20172029.CrossRefGoogle ScholarPubMed
Alloubani, A, Akhu-Zaheya, L, Samara, Ret al. (2019) Relationship between vitamin D deficiency, diabetes, and obesity. Diabetes Metab Syndr 13, 14571461.CrossRefGoogle ScholarPubMed
Ginde, AA, Mansbach, JM & Camargo, CA Jr (2009) Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the third national health and nutrition examination survey. Arch Intern Med 169, 384390.CrossRefGoogle ScholarPubMed
Kamen, D & Aranow, C (2008) Vitamin D in systemic lupus erythematosus. Curr Opin Rheumatol 20, 532537.CrossRefGoogle ScholarPubMed
Krysiak, R, Szwajkosz, A & Okopień, B (2018) The effect of low vitamin D status on sexual functioning and depressive symptoms in apparently healthy men: a pilot study. Int J Impot Res 30, 224229.CrossRefGoogle ScholarPubMed
Park, JH, Hong, IY, Chung, JWet al. (2018) Vitamin D status in South Korean population: seven-year trend from the KNHANES. Medicine 97, e11032.CrossRefGoogle ScholarPubMed
Lopez, AD, Mathers, CD, Ezzati, Met al. (2006) Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 367, 17471757.CrossRefGoogle ScholarPubMed
World Health Organization (2017) Depression and Other Common Mental Disorders: Global Health Estimates. Geneva: World Health Organization.Google Scholar
Rugulies, R, Ando, E, Ayuso-Mateos, JLet al. (2019) WHO/ILO work-related burden of disease and injury: protocol for systematic reviews of exposure to long working hours and of the effect of exposure to long working hours on depression. Environ Int 125, 515528.CrossRefGoogle Scholar
Ministry of Health and Welfare & Korea Centers for Disease Control and Prevention (2017) Korea Health Statistics. Korea National Health and Nutrition Examination Survey (KNHANES). https://knhanes.cdc.go.kr/knhanes/sub04/sub04_03.do?classType=7 (accessed July 2019).Google Scholar
Cho, MJ, Seong, SJ, Park, JEet al. (2015) Prevalence and correlates of DSM-IV mental disorders in South Korean adults: the Korean epidemiologic catchment area study 2011. Psychiatry Investig 12, 164170.CrossRefGoogle ScholarPubMed
Rost, KM, Meng, H & Xu, S (2014) Work productivity loss from depression: evidence from an employer survey. BMC Health Serv Res 14, 597.CrossRefGoogle ScholarPubMed
Rappaport, LM, Flint, J & Kendler, KS (2017) Clarifying the role of neuroticism in suicidal ideation and suicide attempt among women with major depressive disorder. Psychol Med 47, 23342344.CrossRefGoogle ScholarPubMed
Salvo, L, Ramírez, J & Castro, A (2019) Risk factors for suicide attempts in people with depressive disorders treated in secondary health care. Rev Med Chil 147, 181189.CrossRefGoogle ScholarPubMed
Can, , Baykan, H, Baykan, Öet al. (2017) Vitamin D levels and vitamin D receptor gene polymorphism in major depression. Psychiatr Danub 29, 179185.Google ScholarPubMed
Jung, IK (2013) Prevalence of vitamin D deficiency in Korea: results from KNHANES 2010 to 2011. J Nutr Health 46, 540551.Google Scholar
Pan, WH & Yeh, WT (2008) How to define obesity? Evidence-based multiple action points for public awareness, screening, and treatment: an extension of Asian-Pacific recommendations. Asia Pac J Clin Nutr 17, 370374.Google ScholarPubMed
Korea Centers for Disease Control & Prevention (2019) Korea National Health & Nutrition Examination Survey. https://knhanes.cdc.go.kr/knhanes/eng/index.do (accessed December 2019).Google Scholar
Seamans, KM & Cashman, KD (2009) Existing and potentially novel functional markers of vitamin D status: a systematic review. AmJ Clin Nutr 89, 1997S2008S.CrossRefGoogle ScholarPubMed
Pludowski, P, Holick, MF, Grant, WBet al. (2018) Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol 175, 125135.CrossRefGoogle ScholarPubMed
Thacher, TD & Clarke, BL (2011) Vitamin D insufficiency. Mayo Clin Proc 86, 5060.CrossRefGoogle ScholarPubMed
Vilagut, G, Forero, CG, Barbaglia, Get al. (2016) Screening for depression in the general population with the Center for Epidemiologic Studies Depression (CES-D): a systematic review with meta-analysis. PLoS ONE 11, e0155431.CrossRefGoogle Scholar
Moon, JR, Huh, J, Song, Jet al. (2017) The Center for Epidemiologic Studies Depression Scale is an adequate screening instrument for depression and anxiety disorder in adults with congenital heart disease. Health Qual Life Outcomes 15, 176.CrossRefGoogle Scholar
Weissman, MM, Sholomskas, D, Pottenger, Met al. (1977) Assessing depressive symptoms in five psychiatric populations: a validation study. Am J Epidemiol 106, 203214.CrossRefGoogle ScholarPubMed
Leung, RY, Cheung, BM, Nguyen, USet al. (2017) Optimal vitamin D status and its relationship with bone and mineral metabolism in Hong Kong Chinese. Bone 97, 293298.CrossRefGoogle ScholarPubMed
Shin, C, Kim, Y, Park, Set al. (2017) Prevalence and associated factors of depression in general population of Korea: results from the Korea National Health and Nutrition Examination Survey, 2014. J Korean Med Sci 32, 18611869.CrossRefGoogle ScholarPubMed
Kim, E, Jo, SA, Hwang, JYet al. (2005) A survey of depressive symptoms among South Korean adults after the Korean financial crisis of late 1997: prevalence and correlates. Ann Epidemiol 15, 145152.CrossRefGoogle ScholarPubMed
Lee, DM, Tajar, A, O’Neill, TWet al. (2011) Lower vitamin D levels are associated with depression among community-dwelling European men. J Psychopharmacol 25, 13201328.CrossRefGoogle ScholarPubMed
Milaneschi, Y, Shardell, M, Corsi, AMet al. (2010) Serum 25-hydroxyvitamin D and depressive symptoms in older women and men. J Clin Endocrinol Metab 95, 32253233.Google ScholarPubMed
May, HT, Bair, TL, Lappé, DLet al. (2010) Association of vitamin D levels with incident depression among a general cardiovascular population. Am Heart J 159, 10371043.CrossRefGoogle ScholarPubMed
Jorde, R, Waterloo, K, Saleh, Fet al. (2006) Neuropsychological function in relation to serum parathyroid hormone and serum 25–hydroxyvitamin D levels. The Tromsø study. J Neurol 253, 464470.CrossRefGoogle ScholarPubMed
Carswell, S (1997) Vitamin D in the nervous system: actions and therapeutic potential. In Vitamin D, pp. 11971211 [Feldman, D, Glorieux, FH, Pike, JW, editors]. San Diego: Academic Press.Google Scholar
Stumpf, WE, Sar, M, Clark, SAet al. (1982) Brain target sites for 1,25-dihydroxyvitamin D3. Science 215, 14031405.CrossRefGoogle ScholarPubMed
Petersen, P (1968) Psychiatric disorders in primary hyperparathyroidism. J Clin Endocrinol Metab 28, 14911495.CrossRefGoogle ScholarPubMed
Watson, LC & Marx, CE (2002) New onset of neuropsychiatric symptoms in the elderly: possible primary hyperparathyroidism. Psychosomatics 43, 413417.CrossRefGoogle ScholarPubMed
Gugger, A, Marzel, A, Orav, EJet al. (2019) Effect of monthly high-dose vitamin D on mental health in older adults: secondary analysis of a RCT. J Am Geriatr Soc 67, 12111217.CrossRefGoogle ScholarPubMed
Lansdowne, AT & Provost, SC (1998) Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology 135, 319323.CrossRefGoogle ScholarPubMed
Vieth, R, Kimball, S, Hu, Aet al. (2004) Randomized comparison of the effects of the vitamin D3 adequate intake versus 100 mcg (4000 IU) per day on biochemical responses and the wellbeing of patients. Nutr J 3, 818.CrossRefGoogle ScholarPubMed
Meng, X, Li, X, Timofeeva, MNet al. (2019) Phenome-wide Mendelian-randomization study of genetically determined vitamin D on multiple health outcomes using the UK Biobank study. Int J Epidemiol 48, 14251434.CrossRefGoogle ScholarPubMed
Milaneschi, Y, Peyrot, WJ, Nivard, MGet al. (2019) A role for vitamin D and omega-3 fatty acids in major depression? An exploration using genomics. Transl Psychiatry 9, 219.CrossRefGoogle ScholarPubMed
Leino, A, Turpeinen, U & Koskinen, P (2008) Automated measurement of 25-OH vitamin D3 on the Roche Modular E170 analyzer. Clin Chem 54, 20592062.CrossRefGoogle ScholarPubMed
Vázquez-Lorente, H, Herrera-Quintana, L, Quintero-Osso, Bet al. (2019) Current trends in the analytical determination of vitamin D. Nutr Hosp 28. doi: 10.20960/nh.02713.Google Scholar

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