Skip to main content Accessibility help
×
Home
Hostname: page-component-684bc48f8b-vmws4 Total loading time: 2.837 Render date: 2021-04-12T04:14:16.558Z Has data issue: true Feature Flags: { "shouldUseShareProductTool": true, "shouldUseHypothesis": true, "isUnsiloEnabled": true, "metricsAbstractViews": false, "figures": false, "newCiteModal": false, "newCitedByModal": true }

Determination of variability in serum low density lipoprotein cholesterol response to the replacement of dietary saturated fat with unsaturated fat, in the Reading, Imperial, Surrey Saturated fat Cholesterol Intervention (‘RISSCI’) project

Published online by Cambridge University Press:  22 January 2020

A. Koutsos
Affiliation:
Hugh Sinclair Unit of Human Nutrition, Department of Nutritional Sciences, University of Reading, RG6 6AP
R. Antoni
Affiliation:
Department of Nutritional Sciences, University of Surrey, GU2 7WG
E. Ozen
Affiliation:
Hugh Sinclair Unit of Human Nutrition, Department of Nutritional Sciences, University of Reading, RG6 6AP
G. Wong
Affiliation:
Hugh Sinclair Unit of Human Nutrition, Department of Nutritional Sciences, University of Reading, RG6 6AP
L. Sellem
Affiliation:
Hugh Sinclair Unit of Human Nutrition, Department of Nutritional Sciences, University of Reading, RG6 6AP
L. Jin
Affiliation:
Hugh Sinclair Unit of Human Nutrition, Department of Nutritional Sciences, University of Reading, RG6 6AP
H. Ayyad
Affiliation:
Department of Nutritional Sciences, University of Surrey, GU2 7WG
N. Jackson
Affiliation:
Department of Nutritional Sciences, University of Surrey, GU2 7WG
B. A. Fielding
Affiliation:
Department of Nutritional Sciences, University of Surrey, GU2 7WG
M. D. Robertson
Affiliation:
Department of Nutritional Sciences, University of Surrey, GU2 7WG
K. G. Jackson
Affiliation:
Hugh Sinclair Unit of Human Nutrition, Department of Nutritional Sciences, University of Reading, RG6 6AP
J. A. Lovegrove
Affiliation:
Hugh Sinclair Unit of Human Nutrition, Department of Nutritional Sciences, University of Reading, RG6 6AP
B. A. Griffin
Affiliation:
Department of Nutritional Sciences, University of Surrey, GU2 7WG
Rights & Permissions[Opens in a new window]

Abstract

Type
Abstract
Copyright
Copyright © The Authors 2020

Reducing serum low density lipoprotein-cholesterol (LDL-C) by lowering the intake of saturated fatty acids (SFA) to no more than 10% of total energy, remains the mainstay of dietary guidelines to prevent cardiovascular diseases(1). However, there is marked inter-individual variation in the serum LDL-C response to the lowering of SFA. If the variability of this response exceeds the potential reduction in LDL-C, then this may limit the usefulness of this recommendation in the UK population. The overall aim of the RISSCI project is to investigate the mechansims underlying variation in serum LDL-C to dietary SFA, to inform more personalised dietary approaches. To achieve this aim, a study (RISSCI-1) was designed to reproduce the variation in serum LDL-C seen in large dietary intervention trials(Reference Jebb, Lovegrove and Griffin2, Reference Vafeiadou, Weech and Altowaijri3). Participants showing hyper and hypo-responsiveness to a reduction in SFA could then be selected and retained for further metabolic investigations (RISCCI-2).

In RISSCI-1, healthy men were recruited at the Universities of Reading and Surrey (n = 109, mean age 48 (range 30–65 years), mean BMI 25.2 (range 19.1–33.3 kg/m2), and were asked to follow a high SFA diet (18% total energy) for 4 weeks, and then a diet of lower SFA content, equivalent to that of National dietary guideline (≤ 10% total energy) for a further 4 weeks. Dietary SFA was replaced with mono and polyunsaturated fatty acids (MUFA and PUFA) using a food exchange model(Reference Antoni, Sellem and Koutsos4). The diets were iso-energetic, and dietary intake was determined by 4-day diet diaries (0, 4, 8 weeks). Serum total cholesterol (TC), triacylglycerol (TAG) and HDL-cholesterol (HDL-C) were measured by commercially available colorimetric assays, and LDL-C calculated by the Friedewald formula, at baseline, post-high SFA diet, and post-lower SFA diet.

Replacement of dietary SFA with MUFA and PUFA was achieved with good compliance(Reference Antoni, Sellem and Koutsos4), no effect on BMI, and produced significant reductions in total serum TC and LDL-C of 0.64 (12%) and 0.5 mmol/L (15%), respectively, within 4 weeks (High vs Lower SFA). Inter-individual variation in the change in serum LDL-C ranged from -40% (-1.2mmo/L) to + 20% (3.2mmol/L), and was of a magnitude previously observed in longer-term intervention trials(Reference Jebb, Lovegrove and Griffin2, Reference Vafeiadou, Weech and Altowaijri3).

Fig. 1.

These findings support the effectiveness of the dietary guideline to replace SFA with MUFA and PUFA to reduce serum LDL-C, in a short-term intervention. They also demonstrate large inter-individual variation in serum LDL-C, which will allow further investigation of the metabolic and/or genetic origins of this phenomenon in RISCCI-2.

Biotechnology & Biological Sciences Research Council Grant No. BB/P010245/1

References

Scientific Advisory Committee on Nutrition (2019) Saturated Fats and Health Report: https://www.gov.uk/government/publications/saturated-fats-and-health-sacn-report.Google Scholar.Google Scholar
Jebb, SA, Lovegrove, JA, Griffin, BA et al. (2010) Am J Clin Nutr 92, 748–58.Google Scholar
Vafeiadou, K, Weech, M, Altowaijri, H et al. (2015) Am J Clin Nutr 102, 40–8.10.3945/ajcn.114.097089CrossRefGoogle Scholar
Antoni, R, Sellem, L, Koutsos, A et al. (2019) Proc Nutr Soc 78, OCE1.CrossRefGoogle Scholar

Full text views

Full text views reflects PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.

Total number of HTML views: 70
Total number of PDF views: 125 *
View data table for this chart

* Views captured on Cambridge Core between 22nd January 2020 - 12th April 2021. This data will be updated every 24 hours.

Access Access

Send article to Kindle

To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Determination of variability in serum low density lipoprotein cholesterol response to the replacement of dietary saturated fat with unsaturated fat, in the Reading, Imperial, Surrey Saturated fat Cholesterol Intervention (‘RISSCI’) project
Available formats
×

Send article to Dropbox

To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

Determination of variability in serum low density lipoprotein cholesterol response to the replacement of dietary saturated fat with unsaturated fat, in the Reading, Imperial, Surrey Saturated fat Cholesterol Intervention (‘RISSCI’) project
Available formats
×

Send article to Google Drive

To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

Determination of variability in serum low density lipoprotein cholesterol response to the replacement of dietary saturated fat with unsaturated fat, in the Reading, Imperial, Surrey Saturated fat Cholesterol Intervention (‘RISSCI’) project
Available formats
×
×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *