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Considerations for determining ‘optimal nutrition’ for copper, zinc, manganese and molybdenum

Published online by Cambridge University Press:  28 February 2007

Mark L. Failla
Mark L. Failla*
Affiliation:
Department of Nutrition and Foodservice Systems, The University of North Carolina at Greensboro, Greensboro, NC 27402, USA
*
Corresponding author: Professor Mark L. Failla, fax +1 336 334 4129, email mlfailla@uncg.edu
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Abstract

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Defining optimal dietary intakes of Cu and Zn throughout the life cycle continues to present a considerable challenge for nutrition scientists. Although the daily intake of these micronutrients is below that currently recommended for many groups, traditional biochemical indicators of nutritional status for these trace metals largely remain within the normal range. Thus, it is unclear whether the recommended daily intakes may be unnecessarily high, or if the commonly-used markers simply lack the necessary sensitivity and specificity that are required for accurately assessing Cu and Zn status. The increasing number of reports that daily supplements with these trace metals enhance the activities of selective metalloenzymes and specific cellular and organ processes further points out the need to differentiate between meeting the requirement and providing optimal nutriture. Results from recent studies suggesting that alternative molecular and functional markers possess sufficient sensitivity to better assess Cu and Zn status are discussed. Likewise, recent studies evaluating the impact of very low and excessive levels of dietary Mn and Mo on selective biochemical and metabolic indicators are reviewed.

Keywords

CopperZincManganeseMolybdenumNutritional assessment
Type
‘Optimal nutrition’
Information
Proceedings of the Nutrition Society , Volume 58 , Issue 2 , May 1999 , pp. 497 - 505
Copyright
Copyright © The Nutrition Society 1999

References

Abumrad, NM, Schneider, AJ, Steele, D & Rogers, LS (1981) Amino acid intolerance during prolonged total parenteral nutrition reversed by molybdate therapy. American Journal of Clinical Nutrition 34, 2551–2559.CrossRefGoogle ScholarPubMed
Aggett, PJ & Comerford, JG (1995) Zinc and human health. Nutrition Reviews 53, S16–S22.Google ScholarPubMed
Bala, S & Failla, ML (1992) Copper deficiency reversibly impairs DNA synthesis in activated T lymphocytes by limiting interleukin-2 activity. Proceedings of the National Academy of Sciences USA 89, 6794–6797.CrossRefGoogle ScholarPubMed
Bales, CW, DiSilvestro, RA, Currie, KL, Plaisted, CS, Joung, H, Galanos, AN & Lin, PH (1994) Marginal zinc deficiency in older adults: responsiveness of zinc status indicators. Journal of the American College of Nutrition 13, 455–462.Google Scholar
Beshgetoor, D & Hambidge, M (1998) Clinical conditions altering copper metabolism in humans. American Journal of Clinical Nutrition 67, 1017S–1021S.Google Scholar
Blostein-Fujii, A, DiSilvestro, RA, Frid, D, Katz, C & Malarkey, W (1997) Short-term zinc supplementation in women with non-insulin-dependent diabetes mellitus: effects on plasma 5′-nucleotidase activities, insulin-like growth factor I concentrations, and lipoprotein oxidation rates in vitro. American Journal of Clinical Nutrition 66, 639–642.CrossRefGoogle ScholarPubMed
Bremner, I (1998) Manifestations of copper excess. American Journal of Clinical Nutrition 67, 1069S–1073S.CrossRefGoogle ScholarPubMed
Bremner, I, Morrison, JN, Wood, AM & Arthur, JR (1987) Effects of changes in dietary zinc, copper and selenium supply and of endotoxin administration on metallothionein I concentrations in blood cells and urine in the rat. Journal of Nutrition 117, 1595–1602.CrossRefGoogle ScholarPubMed
Chesters, JK (1997) Zinc. In Handbook of Nutritionally Essential Mineral Elements, pp. 185–230 [O'Dell, BL and Sunde, RA, editors]. New York: Marcel Dekker Inc.Google Scholar
Cousins, RJ (1996) Zinc. In Present Knowledge in Nutrition, 7th ed., pp. 293–306 [Ziegler, EE and Filer, LJ Jr, editors]. Washington, DC: ILSI Press.Google Scholar
Dameron, CT & Harrison, MD (1998) Mechanisms for protection against copper toxicity. American Journal of Clinical Nutrition 67, 1091S–1097S.CrossRefGoogle ScholarPubMed
Davis, CD & Greger, JL (1992) Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women. American Journal of Clinical Nutrition 55, 747–752.Google Scholar
Davis, SR, McMahon, RJ & Cousins, RJ (1998) Metallothionein knockout and transgenic mice exhibit altered intestinal processing of zinc with uniform zinc-dependent zinc transporter-1 expression. Journal of Nutrition 128, 825–831.CrossRefGoogle ScholarPubMed
DiSilvestro, RA, Jones, AA, Smith, D & Wildman, R (1997) Plasma diamine oxidase activities in renal dialysis patients, a human with spontaneous copper deficiency and marginally copper deficient rats. Clinical Biochemistry 30, 559–563.CrossRefGoogle ScholarPubMed
Doisy, EA Jr. (1974) Effects of deficiency in manganese upon plasma levels of clotting proteins and cholesterol in man. In Trace Element Metabolism in Animals-2, pp. 668–670 [Hoekstra, WG, Suttie, JW, Ganther, HE and Mertz, W, editors]. Baltimore, MD: University Park Press.Google Scholar
Eaton-Evans, J, McIlrath, EM, Jackson, WE, McCartney, H & Strain, JJ (1996) Copper supplementation and the maintenance of bone mineral density in middle-aged women. Journal of Trace Elements in Experimental Medicine 9, 87–94.3.0.CO;2-E>CrossRefGoogle Scholar
Eipper, BA, Stoffers, DA & Mains, RE (1992) The biosynthesis of neuropeptides: peptide amidation. Annual Review of Neuro-science 15, 57–85.Google Scholar
Failla, ML & Hopkins, RG (1998) Is low copper status immunosuppressive? Nutrition Reviews 56, S59–S64.CrossRefGoogle ScholarPubMed
Fell, JME, Reynolds, AP, Meadows, N, Khan, K, Long, SG, Quaghebeur, G, Taylor, WJ & Milla, PJ (1996) Manganese toxicity in children receiving long-term parenteral nutrition. Lancet 347, 1218–1221.CrossRefGoogle ScholarPubMed
Fosmire, G (1990) Zinc toxicity. American Journal of Clinical Nutrition 51, 225–227.Google Scholar
Friedman, BJ, Freeland-Graves, JH, Bales, CW, Behmardi, F, Shorey-Kutschke, RL, Willis, RA, Crosby, JB, Trickett, PC & Houston, SD (1987) Manganese balance and clinical observations in young men fed a manganese-deficient diet. Journal of Nutrition 117, 133–143.Google Scholar
Goldenberg, RL, Tamura, T, Neggers, Y, Copper, RL, Johnston, KE, DuBard, MB & Hauth, JC (1995) The effect of zinc supplementation on pregnancy outcome. Journal of the American Medical Association 274, 463–468.Google Scholar
Greger, JL (1998) Dietary standards for manganese: Overlap between nutritional and toxicological studies. Journal of Nutrition 128, 368S–371S.Google Scholar
Grider, A, Bailey, LB & Cousins, RJ (1990) Erythrocyte metallothionein as an index of zinc status in humans. Proceedings of the National Academy of Sciences USA 87, 1259–1262.Google Scholar
Harris, ED (1997) Copper. In Handbook of Nutritionally Essential Mineral Elements, pp. 231–274 [O'Dell, BL and Sunde, RA, editors]. New York: Marcel Dekker Inc.Google Scholar
Harris, ZL, Klomp, LWJ & Gitlin, JD (1998) Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis. American Journal of Clinical Nutrition 67, 972S–977S.Google Scholar
Hopkins, RG & Failla, ML (1995) Chronic intake of a marginally low copper diet impairs in vitro activities of lymphocytes and neutrophils from male rats despite minimal impact on conventional indicators of copper status. Journal of Nutrition 125, 2658–2668.Google Scholar
Hopkins, RG & Failla, ML (1997) Copper deficiency reduces interleukin-2 (IL-2) production and IL-2 mRNA in human T-lymphocytes. Journal of Nutrition 127, 257–262.Google ScholarPubMed
Hopkins, RG & Failla, ML (1999) Transcriptional regulation of interleukin-2 gene expression is impaired by copper deficiency in Jurkat human T lymphocytes. Journal of Nutrition 129, 595–601.CrossRefGoogle ScholarPubMed
Johnson, JL (1997) Molybdenum. In Handbook of Nutritionally Essential Mineral Elements, pp. 413–438 [O'Dell, BL and Sunde, RA, editors]. New York: Marcel Dekker Inc.Google Scholar
Johnson, MA, Smith, MM & Edmonds, JT (1998) Copper, iron, zinc, and manganese in dietary supplements, infant formulas, and ready-to-eat breakfast cereals. American Journal of Clinical Nutrition 67, 1035S–1040S.CrossRefGoogle ScholarPubMed
Jones, AA, DiSilvestro, RA, Coleman, M & Wagner, TL (1997) Copper supplementation of adult men: Effects on blood copper enzyme activities and indicators of cardiovascular disease risk. Metabolism 46, 1380–1383.CrossRefGoogle ScholarPubMed
Joung, H, DiSilvestro, RA, Burge, JC, Choban, PS & Flancbaum, L (1998) Zinc and copper-related blood parameters in male trauma patients. Nutrition Research 18, 693–701.Google Scholar
Keen, CL & Zidenberg-Cherr, S (1996) Manganese. In Present Knowledge in Nutrition, 7th ed., pp. 334–343 [Ziegler, EE and Filer, LJ Jr, editors]. Washington, DC: ILSI Press.Google Scholar
Kehoe, CA, Turley, E, Bonham, MP, O'Connor, JM, McKeown, A, Faughnan, MS, Coulter, JA, Gilmore, WS, Howard, AN & Strain, JJ (1999) Responses of putative indices of copper status to copper supplementation in human volunteers: The FOODCUE project. British Journal of Nutrition (In the Press).Google Scholar
Kelley, DS, Daudu, PA, Taylor, PC, Mackey, BE & Turnland, JR (1995) Effects of low copper diet on human immune responses. American Journal of Clinical Nutrition 62, 412–416.Google Scholar
Leach, RM Jr. & Harris, ED (1997) Manganese. In Handbook of Nutritionally Essential Mineral Elements, pp. 335–356 [O'Dell, BL and Sunde, RA, editors]. New York: Marcel Dekker Inc.Google Scholar
Linder, MC (1996) Copper. In Present Knowledge in Nutrition, 7th ed., pp. 307–319 [Ziegler, EE and Filer, LJ Jr, editors]. Washington, DC: ILSI Press.Google Scholar
Lonnerdal, B & Uauy, R (1998) Genetic and environmental determinants of copper metabolism. American Journal of Clinical Nutrition 67, 960S–964S.Google Scholar
Lukaski, HC, Hoverson, BS, Gallagher, S & Bolonchuk, WW (1990) Physical training and copper, iron, and zinc status of swimmers. American Journal of Clinical Nutrition 51, 1093–1099.Google Scholar
McMahon, RJ & Cousins, RJ (1998 a) Mammalian zinc transporters. Journal of Nutrition 128, 667–670.Google Scholar
McMahon, RJ & Cousins, RJ (1998 b) Regulation of the zinc transporter ZnT-1 by dietary zinc. Proceedings of the National Academy of Sciences USA 95, 4841–4846.CrossRefGoogle ScholarPubMed
Mains, RE, Myers, AC & Eipper, BA (1985) Hormonal, drug, and dietary factors affecting peptidylglycine α-amidating monooxygenase activity in various tissues of the adult male rat. Endocrinology 116, 2505–2515.CrossRefGoogle ScholarPubMed
Mains, RE, Park, LP & Eipper, BA (1986) Inhibition of peptide amidation by disulfiram and diethyldithiocarbonate. Journal of Biological Chemistry 261, 11938–11941.Google Scholar
Milne, DB (1994) Assessment of copper nutritional status. Clinical Chemistry 40, 1479–1484.CrossRefGoogle ScholarPubMed
Milne, DB (1998) Copper intake and assessment of copper status. American Journal of Clinical Nutrition 67, 1041S–1045S.Google Scholar
Milne, DB & Nielsen, FH (1996) Effects of a diet low in copper on copper status indicators in postmenopausal women. American Journal of Clinical Nutrition 63, 358–364.Google Scholar
National Research Council (1989) Recommended Dietary Allowances, 10th ed. Washington, DC: National Academy Press.Google Scholar
Olivares, M, Pizarro, F, Speisky, H, Lonnerdal, B & Uauy, R (1998) Copper in infant nutrition: Safety of World Health Organization provisional guideline value for copper content of drinking water. Journal of Pediatric Gastroenterology and Nutrition 26, 251–257.Google ScholarPubMed
Olivares, M & Uauy, R (1998) Limits of metabolic tolerance of copper and biological basis for present recommendations and regulations. American Journal of Clinical Nutrition 63, 846S–852S.Google Scholar
Pennington, JAT & Jones, JW (1987) Molybdenum, nickel, cobalt, vanadium, and strontium in total diets. Journal of the American Dietetic Association 87, 1644–1650.Google Scholar
Pennington, JAT & Young, BE (1991) Total diet study nutritional elements. Journal of the American Dietetic Association 91, 179–183.Google Scholar
Pratt, WB, Omdahl, JL & Sorenson, JRJ (1985) Lack of effects of copper gluconate supplementation. American Journal of Clinical Nutrition 42, 681–682.CrossRefGoogle ScholarPubMed
Percival, SS (1995) Neutropenia caused by copper deficiency: possible mechanisms of action. Nutrition Reviews 53, 59–66.Google Scholar
Prasad, AS, Fitzgerald, JT, Hess, JW, Kaplan, J, Pelen, F & Dardenne, M (1993) Zinc deficiency in elderly patients. Nutrition 9, 218–224.Google Scholar
Prasad, AS, Meftah, S, Abdallah, J, Kaplan, J, Brewer, GJ, Bach, JF & Dardenne, M (1988) Serum thymulin in human zinc deficiency. Journal of Clinical Investigation 82, 1202–1210.Google Scholar
Prohaska, JR (1997) Responses of rat cuproenzymes to variable dietary copper. Journal of Nutritional Biochemistry 8, 316–321.Google Scholar
Prohaska, JR, Tamura, T, Percy, AK & Turnland, JR (1997) In vitro copper stimulation of plasma peptidylglycine α-amidating monooxygenase in Menkes disease variant with occipital horns. Pediatric Research 42, 862–865.Google Scholar
Sato, M, Mehra, RK & Bremner, I (1984) Measurement of plasma metallothionein-I in the assessment of the zinc status of zinc-deficient and stressed rats. Journal of Nutrition 114, 1683–1689.Google Scholar
Sazawal, S, Black, RE, Bhan, MK, Sinha, A & Bhandari, N (1997) Efficacy of zinc supplementation in reducing the incidence and prevalence of acute diarrhea–a community-based double-blind controlled study. American Journal of Clinical Nutrition 66, 413–418.Google Scholar
Smith, D, Hopkins, RG, Kutlar, A & Failla, ML (1994) Diagnosis and treatment of copper deficiency in adult humans. FASEB Journal 8, A4754.Google Scholar
Strain, JJ (1988) A reassessment of diet and osteoporosis-Possible role for copper. Medical Hypotheses 27, 333–338.Google Scholar
Strause, L, Saltman, P, Smith, KT, Bracker, M & Andon, MB (1994) Spinal bone loss in postmenopausal women supplemented with calcium and trace metals. Journal of Nutrition 124, 1060–1064.Google Scholar
Sullivan, VK, Burnett, FR & Cousins, RJ (1998) Metallothionein expression is increased in monocytes and erythrocytes of young men during zinc supplementation. Journal of Nutrition 128, 707–713.Google Scholar
Sullivan, VK & Cousins, RJ (1997) Competitive reverse transcriptase-polymerase chain reaction shows that dietary zinc supplementation in humans increases monocyte metallothionein mRNA levels. Journal of Nutrition 127, 694–698.Google Scholar
Thomas, EA, Bailey, LB, Kauwell, GA, Lee, DY & Cousins, RA (1992) Erthrocyte metallothionein response to dietary zinc in humans. Journal of Nutrition 122, 2408–2414.Google Scholar
Turnland, JR (1998) Human whole-body copper metabolism. American Journal of Clinical Nutrition 67, 960S–964S.Google Scholar
Turnland, JR, Keyes, WR, Anderson, HL & Acord, LL (1989) Copper absorption and retention in young men at three levels of dietary copper by use of the stable isotope 65Cu. American Journal of Clinical Nutrition 49, 870–878.Google Scholar
Turnland, JR, Keyes, WR & Peiffer, GL (1995 a) Molybdenum absorption, excretion and retention studied with stable isotopes in young men at five intakes of dietary molybdenum. American Journal of Clinical Nutrition 62, 790–796.Google Scholar
Turnland, JR, Keyes, WR, Peiffer, GL & Chiang, G (1995 b) Molybdenum absorption, excretion, and retention studied with stable isotopes in young men during depletion and repletion. American Journal of Clinical Nutrition 61, 1102–1109.Google Scholar
Turnland, JR, Scott, KC, Peiffer, GL, Jang, AM, Keyes, AM, Keen, CL & Sakanaski, TM (1997) Copper status of young men consuming a low-copper diet. American Journal of Clinical Nutrition 65, 72–78.Google Scholar
Van Dokkum, W (1995) The intake of selected minerals and trace elements in European countries. Nutrition Research Reviews 8, 271–302.Google Scholar
Werman, MJ, Bhathena, SJ & Turnland, JR (1997) Dietary copper intake influences skin lysyl oxidase in young men. Journal of Nutritional Biochemistry 8, 201–204.Google Scholar
Wolvekamp, MC & deBruin, RW (1994) Diamine oxidase: an overview of historical, biochemical and functional aspects. Digestive Diseases 12, 2–14.Google Scholar