Hostname: page-component-848d4c4894-4rdrl Total loading time: 0 Render date: 2024-06-25T15:13:17.106Z Has data issue: false hasContentIssue false
  • English
  • Français

Schistosoma mansoni: an ultrastructural examination of pulmonary migration

Published online by Cambridge University Press:  06 April 2009

Jean E. Crabtree  and
R. A. Wilson
Jean E. Crabtree
Affiliation:
Department of Biology, University of York, Heslington, York YO1 5DD
R. A. Wilson
Affiliation:
Department of Biology, University of York, Heslington, York YO1 5DD
Get access Rights & Permissions [Opens in a new window]

Summary

The migration of schistosomula through the lungs of mice has been investigated at the ultrastructural level. On Days 4 and 7 post-infection schistosomula were located only within the vasculature. Newly arrived Day 4 schistosomula were highly convoluted and completely occluded vessels measuring approximately 15–25μm in diameter. By Day 7 parasites were located in pulmonary capillaries, often causing considerable distension. The subtegumentary fibrous interstitial layer was absent in elongated lung schistosomula. The minimum diameter of such parasites was 8μm, and their tegument was usually unridged and flattened against the vascular endothelium, thus resulting in close apposition of endothelial and tegumental membranes. The tight fit of schistosomula in the pulmonary capillaries implies that migration through them is both a strenuous and slow process. The migratory delay in the lungs after arrival from the skin occurs because dimensional changes are necessary for successful capillary migration.

Type
Research Article
Information
Parasitology , Volume 92 , Issue 2 , April 1986 , pp. 343 - 354
Copyright
Copyright © Cambridge University Press 1986

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Bentley, A. G., Carlisle, A. S. & Phillips, S. M. (1981). Ultrastructural analysis of the cellular response to Schistosoma mansoni: initial and challenge infections in the rat. American Journal of Tropical Medicine and Hygiene 30, 102–12.CrossRefGoogle ScholarPubMed
Blum, K. & Cioli, D. (1981). Schistosoma mansoni: age dependent susceptibility to immune elimination of schistosomula artificially introduced into preinfected mice. Parasite Immunology 3, 13–24.CrossRefGoogle ScholarPubMed
Bruce, J. I., Pezzlo, F., Yajima, Y. & McCarty, J. E. (1974). Schistosoma mansoni: pulmonary phase of schistosomule migration studied by electron microscopy. Experimental Parasitology 35, 150–60.CrossRefGoogle ScholarPubMed
Chapman, G. (1958). The hydrostatic skeleton in the invertebrates. Biological Reviews 33, 338–71.CrossRefGoogle Scholar
Clark, R. B. & Cowey, J. B.(1958). Factors controlling the change in shape of certain Nemertean and Turbellarian worms. Journal of Experimental Biology 35, 731–48.CrossRefGoogle Scholar
Crabtree, J. E. (1982). An ultrastructural study of the migrating schistosomulum of Schistosoma mansoni. D. Phil. thesis, University of York.Google Scholar
Crastree, J. E. & WILSON, R. A.(1980). Schistosoma mansoni: a scanning electron microscope study of the developing schistosomulum. Parasitology 81, 553–64.CrossRefGoogle Scholar
Crastree, J. E. & Wilson, R. A. (1985). Shistosoma mansoni: an ultrastructural examination of skin migration in the hamster cheek pouch. Parasitology 91, 111–20.CrossRefGoogle Scholar
Dean, D. A. & Mangold, B. L. (1984). Autoradiographic analysis of resistance to reinfection with Schistosoma mansoni in mice. American Journal of Tropical Medicine and Hygiene 31, 97–103.CrossRefGoogle Scholar
Dean, D. A., Mangold, B. L., Georgi, J. R. & Jacobson, R. H. (1984). Comparison of Schistosoma mansoni migration patterns in normal and irradiated cercaria-immunized mice by means of autoradiographic analysis. Evidence that worm elimination occurs after the skin phase in immunized mice. American Journal of Tropical Medicine and Hygiene 33, 89–96.CrossRefGoogle ScholarPubMed
Faust, E. C., Jones, C. A. & Hoffman, W. A. (1934). Studies on Schistosomiasis mansoni in Puerto Rico. 2. The mammalian phase of the life cycle. Puerto Rican Journal of Public Health and Tropical Medicine 10, 133–96.Google Scholar
Hawkings, F. & Clark, J. B. (1967). The periodicity of microfilariae. XIII. Movements of Dipetalonema witei microfilariae in the lungs. Transactions of the Royal Society of Tropical Medicine and Hygiene 61, 817–26.CrossRefGoogle Scholar
Hockley, D. J. (1973). Ultrastructure of the tegument of Schistosoma. In Advances in Parasitology vol. 11 (ed. Dawes, B.), pp. 233–305. London: Academic Press.Google Scholar
Lawson, J. R. & Wilson, R. A. (1980). Metabolic changes associated with the migration of the schistosomulum of Shistosoma mansoni in the mammalian host. Parasitology 81, 325–36.CrossRefGoogle Scholar
Lichtenberg, F. Von & Byram, J. E. (1980). Pulmonary cell reactions in natural and acquired host resistance to Schistosolna mansoni. American Journal of Tropical Medicine and Hygien 29, 1286–300.CrossRefGoogle Scholar
McLaren, D. J., Hockley, D. J., Goldring, O. L. & Hammond, B. J. (1978). A freeze fracture study of the developing tegumental outer membrane of Schistosoma mansoni. Parasitology 76, 327–48.CrossRefGoogle ScholarPubMed
Miller, P. (1976). The migration of the human blood fluke Schistosoma mansoni, and its subsequent development in the mammalian host. D. Phil thesis, University of York.Google Scholar
Miller, P. & Wilson, R. A. (1978). Migration of schistosomula of Schistosoma mansoni from skin to lungs. Parasitology 77, 281–302.CrossRefGoogle ScholarPubMed
Miller, P. & Wilson, R. A. (1980). Migration of the schistosomula of Schistosoma mansoni from lungs to the hepatic portal system. Parasitology 80, 267–88.CrossRefGoogle Scholar
Nuttman, C. J. (1975). The structure and behaviour of the cercariae of Shistosoma mansoni. D. Phil. thesis, University of York.Google Scholar
Reissig, M. (1970). Characterisation of cell types in the parenchyma of Schistosoma mansoni. Parasitology 60, 273–9.CrossRefGoogle ScholarPubMed
Rhodin, J. A. G. (1977). Histology. A Text and Atlas. London: Oxford University Press.Google Scholar
Samuelson, J. C., Caulfield, J. P. & David, J. R. (1980). Schistosoma mansoni: post-transformational surface changes in schistosomula grown in vitro and in mice. Experimental Parasitology 50, 369–83.CrossRefGoogle ScholarPubMed
Sher, A., Sacks, D. L., Simpson, A. J. & Singer, A. (1984). Dichotomy in the tissue origin of schistosome acquired class I and class II major histocompatibility antigens. Journal of Experimental Medicine 159, 952–7.CrossRefGoogle Scholar
Silk, M. H. & Spence, I. M. (1969). Ultrastructural studies on the blood fluke Schistosoma mansoni. II. The musculature. South African Journal of Medical Science 34, 11–20.Google ScholarPubMed
Smithers, S. R. & Terry, R. J. (1965). The infection of laboratory hosts with cercariae of Schistosoma mansoni and the recovery of adults. Parasitology 55, 695–700.CrossRefGoogle Scholar
Stirewalt, M. A. (1959). Chronological analysis, pattern and rate of migration of Schistosoma mansoni in body, ear and tail skin of mice. Annals of Tropical Medicine and Parasitology 53, 400–13.CrossRefGoogle ScholarPubMed
West, J. B., Glazier, J. B., Hughes, J. M. B. & Maloney, J. E. (1969). Pulmonary capillary flow, diffusion, Ventilation and gas exchange. In Ciba Foundation, Circulatory and Respiratory Mass Transport, pp. 256–272. Edinburgh: J. & A. Churchill.CrossRefGoogle Scholar
Wheater, P. R. & Wilson, R. A. (1979). Schistosoma mansoni: a histological study of migration in the laboratory mouse. Parasitology 79, 49–62.CrossRefGoogle ScholarPubMed
Wilson, R. A. & Coulson, P. S. (1986). Schistosoma mansoni: dynamics of migration through the vascular system of the mouse. Parasitology 92, 83–100.CrossRefGoogle ScholarPubMed
Wilson, R. A., Draskau, T., Miller, P. & Lawson, J. R. (1978). Schistosoma mansoni: the activity and development of the schistosomulum during migration from the skin to the hepatic portal system. Parasitology 77, 57–73.CrossRefGoogle Scholar
Wilson, R. A. & Lawson, J. R. (1980). An examination of the skin phase of migration using a hamster cheek pouch preparation. Parasitology 80, 257–66.CrossRefGoogle ScholarPubMed
Yolles, T. E., Moore, D. V. & Meleney, H. E. (1949). Post cercarial development of Schistosoma mansoni in the rabbit and hamster after intraperitoneal and percutaneous infection. Journal of Parasitology 35, 276–94.CrossRefGoogle ScholarPubMed