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Molecular characterization of antigen 24, a specific immunodominant antigen family from Leishmania infantum

  • B. COUVREUR (a1) (a2), D. JACQUET (a1), A. BOLLEN (a2) and D. LE RAY (a1)

Abstract

Leishmania infantum immunoelectrophoretic antigen 24 (AG 24), a visceral leishmaniasis associated immunodominant antigen, has been characterized with a monospecific antiserum by combining SDS–PAGE, immunoblotting, metabolic labelling, radio-immunoprecipitation and in vitro poly A+ mRNA translation. AG 24 appeared to correspond to a multi-antigen family of 6–9 members ranging from 20 to 31 kDa and proteinic by nature with no post-translational modifications. A similar banding pattern was recognized by infection sera. AG 24 was not found exposed on the cell surface.

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Corresponding author

Corresponding author: Laboratory for Protozoology, Prince Leopold Institute for Tropical Medicine, Nationalestraat 155, B-2000 Antwerp, Belgium. Tel: +32 3 2476 355. Fax: +32 2 2476 362. E-mail: dleray@proto.itg.be

Keywords

Molecular characterization of antigen 24, a specific immunodominant antigen family from Leishmania infantum

  • B. COUVREUR (a1) (a2), D. JACQUET (a1), A. BOLLEN (a2) and D. LE RAY (a1)

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