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Juvenile female Litomosoides sigmodontis produce an excretory/secretory antigen (Juv-p120) highly modified with dimethylaminoethanol

  • M. HINTZ (a1), G. SCHARES (a2), A. TAUBERT (a2), R. GEYER (a1), H. ZAHNER (a2), S. STIRM (a1) and F. J. CONRATHS (a2)...

Abstract

A 120 kDa antigen produced by juvenile female Litomosoides sigmodontis (Juv-p120) was isolated and purified. The amino acid composition of the molecule was determined. Juv-p120 was shown to be highly modified with N,N-dimethyl-aminoethanol (28·4 mol%). Treatment of Juv-p120 with potassium hydroxide (β-elimination) or with sodium m-periodate leads to the destruction of epitopes recognized by antibodies immune affinity-purified with isolated Juv-p120. Juvenile L. sigmodontis were shown to release Juv-p120 into the pleural cavity of infected Mastomys coucha before the onset of patency.

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Corresponding author

Corresponding author: Institute für Epidemiological Diagnostics, Federal Research Centre for Virus Diseases of Animals, Seestrasse 55, D-16868 Wusterhausen, Germany. Tel: +49 33979 80176. Fax: +49 33979 80222. E-mail: franz.conraths@wus.bfav.de

Keywords

Juvenile female Litomosoides sigmodontis produce an excretory/secretory antigen (Juv-p120) highly modified with dimethylaminoethanol

  • M. HINTZ (a1), G. SCHARES (a2), A. TAUBERT (a2), R. GEYER (a1), H. ZAHNER (a2), S. STIRM (a1) and F. J. CONRATHS (a2)...

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