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Identification of Ras, MAP kinases, and a GAP protein in Schistosoma mansoni by immunoblotting and their putative involvement in male–female interaction

  • P. SCHÜßLER (a1), C. G. GREVELDING (a1) and W. KUNZ (a1)

Abstract

The maturation of female Schistosoma mansoni depends on pairing with a male which induces mitotic activities in the reproductive organs of the female worm. Since in other organisms cell proliferation is regulated by well-conserved signal transducing molecules, we looked for such molecules on immunoblots of schistosomes, using antibodies against conserved epitopes of Ras, GAP and MAP kinases. We identified all 3 molecules in schistosomes and found that they are developmentally regulated. Furthermore, there is evidence for their involvement in the male-directed maturation of the female.

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Corresponding author: Tel. and Fax: +49 211 81 12333. E-mail: Werner.Kunz@uni-duesseldorf.de

Keywords

Identification of Ras, MAP kinases, and a GAP protein in Schistosoma mansoni by immunoblotting and their putative involvement in male–female interaction

  • P. SCHÜßLER (a1), C. G. GREVELDING (a1) and W. KUNZ (a1)

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