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Factors influencing infections in Rhipicephalus appendiculatus ticks fed on cattle infected with Theileria parva

  • A. S. Young (a1), T. T. Dolan (a1), S. P. Morzaria (a1), F. N. Mwakima (a1), R. A. I. Norval (a1), J. Scott (a1), A. Sherriff (a2) and G. Gettinby (a2)...

Summary

A large database on the transmission of a stabilate of the Theileria parva Muguga stock from one breed of cattle using two stocks of Rhipicephalus appendiculatus, Muguga and Ol Pejeta was developed and analysed. Factors associated with the ticks and cattle, and the infections developing in cattle were studied in relation to the infection variables in the tick batches harvested daily from cattle. Generalized Linear Interactive Modelling (GLIM) was used to determine the importance of factors and interactions in influencing the levels of tick infection variables using Type I and Type III sums of squares analyses. Analysis of the 6 variables, prevalence (percentage of ticks infected), abundance (mean number of infected salivary gland acini per tick examined) and intensity (mean number of infected salivary gland acini per infected tick) in batches of 30 male and 30 female ticks showed that 24 covariates, factors or interactions had a significant effect (P> 0·05). Certain covariates and factors were particularly important for all 6 tick infection variables; parasitaemia of animal on the day of tick harvest, stabilate dilution administered to animal, month in which tick batch was harvested, minimum packed cell volume of animal over the sampling period, age of animal, and the minimum leukocyte count of the animal over the sampling period. The GLIM analyses were found to be a useful tool in identifying factors that influence infection levels and in devising methods of producing tick batches with more predictable infections.

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Corresponding author

Corresponding author: Tel: + 254 2 630743. Fax: + 254 2 631499. E-mail: ilri-kenya@cgnet.com.

References

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Bailey, K. P. (1960). Notes on the rearing of Rhipicephalus appendiculatus and their infection with Theileria parva for experimental transmission. Bulletin of Epizootic Diseases of Africa 8, 3343.
Berkvens, D. L. (1990). A study of the ecology of the Rhipicephalus appendiculatus complex with special reference to the Eastern Province of Zambia. Ph.D. thesis, Brunel University.
Brocklesby, D. W., Barnett, S. F. & Scott, G. R. (1961). Morbidity and mortality rates in East Coast fever (Theileria parva infection) and their application to drug screening procedures. British Veterinary Journal 117, 529531.
Byrom, W. & Gettinby, G. (1993). Using the computer model ECFXPERT to study ticks and East Coast fever. Insect Science and its Application 13, 527535.
Büscher, G. & Otim, B. (1986). Quantitative studies on Theileria parva in salivary glands of Rhipicephalus appendiculatus adults: Quantitation and prediction of infection. International Journal for Parasitology 16, 93100.
Büscher, G. & Tangus, J. (1986). Quantitative studies on Theileria parva in salivary glands of Rhipicephalus appendiculatus adults: Search for conditions for high infections. International Journal for Parasitology 16, 121129.
Conrad, P. A., Ole-Moiyoi, O. K., Baldwin, C. L., Dolan, T. T., O'Callaghan, C. J., Njamunggeh, R. E. G., Gootenhuis, J. G., Stagg, D. A., Leitch, B. L. & Young, A. S. (1989). Characterisation of buffalo-derived Theileria parasites with monoclonal antibodies and DNA probes. Parasitology 98, 179188.
Dolan, T. T., Young, A. S., Losos, G. J., McMillan, I., Minder, Ch. E. & Soulsby, K. (1984). Dose dependant responses of cattle to Theileria parva stabilate infection. International Journal for Parasitology 14, 8995.
Fawcett, D. W., Doxsey, S. & Büscher, G. (1982). Salivary gland of the tick vector of East Coast fever. III. Ultrastructure of sporogony in Theileria parva. Tissue and Cell 14, 183206.
Goddeeris, B. M., Katende, J. M., Irvin, A. D. & Chumo, R. S. C. (1982). Indirect fluorescent antibody test for experimental and epizootiological studies on East Coast fever (Theileria parva infection in cattle). Evaluation of a cell culture schizont antigen fixed and stored in suspension. Research in Veterinary Science 33, 360365.
Irvin, A. D., Purnell, R. E. & Peirce, M. A. (1973). Some observations on the feeding behavior of the tick Rhipicephalus appendiculatus (Neumann, 1901) on cattle and rabbits in the laboratory. Tropical Animal Health and Production 5, 8797.
Jarrett, W. F. H., Crighton, G. W. & Pirie, H. M. (1969). Theileria parva. Kinetics of replication. Experimental Parasitology 24, 925.
Kleinbaum, D. G., Kupper, L. & Muller, K. E. (1988). Applied Regression Analysis and Other Multivariable Methods. Boston: PWS-Kent.
Kubasu, S. S. (1992). The ability of Rhipicephalus appendiculatus (Acarina: Ixodidae) stocks in Kenya to become infected with Theileria parva. Bulletin of Entomology Research 83, 349354.
Lewis, E. A. (1950). Conditions affecting the East Coast fever parasite in ticks and cattle. East African Agricultural Journal 16, 6577.
Lewis, E. A. & Fotheringham, W. (1941). The transmission of Theileria parva by ticks. Parasitology 33, 251277.
Lounsbury, C. P. (1906). Ticks and Africa Coast fever. Agricultural Journal of the Cape of Good Hope 28, 634654.
Medley, G. F., Perry, B. D. & Young, A. S. (1993). Preliminary analysis of the transmission dynamics of Theileria parva in eastern Africa. Parasitology 106, 251264.
Milliken, G. A. & Johnson, D. E. (1984). Analysis of Messy Data: Vol. 1, Designed Experiments. Van Nostrand Reinhold, New York.
Moll, G., Lohding, A. & Young, A. S. (1984). Epidemiology of theileriosis in the Trans-Mara Division, Kenya. Husbandry and disease background and preliminary observations on theileriosis of calves. Preventive Veterinary Medicine 2, 801831.
Morzaria, S. P. (1989). Identification of Theileria species and characterization of Theileria parva stocks. In: Theileriosis in Eastern, Central and Southern Africa, (ed. Dolan, T. T.), pp. 102110. International Laboratory for Research on Animal Diseases, Nairobi.
Mukhebi, A. W., Perry, B. D. & Kruska, R. (1992). Estimated economics of theileriosis control in Africa. Preventive Veterinary Medicine 12, 7385.
Musoke, A., Morzaria, S., Nkonge, C., Jones, E. & Nene, v. (1992). A recombinant sporozoite surface antigen of Theileria parva induces protection in cattle. Proceedings of the National Academy of Sciences, USA 89, 514518.
Mutugi, J. J., Young, A. S., Maritim, A. C., Ndungu, S. G., Mining, S. K., Linyonyi, A., Ngumi, P. N., Leitch, B. L., Morzaria, S. P. & Dolan, T. T. (1989). Immunization of cattle against theileriosis in Coast Province, Kenya: Laboratory evaluation of a Theileria parva stabilate for use in ‘infection and treatment’ immunization in the field. Research in Veterinary Science 47, 170177.
Neitz, W. O. (1957). Theileriosis, gonderioses and cytauxzoonoses. A review. Onderstepoort Journal of Veterinary Research 27, 275430.
Norval, R. A. I., Perry, B. D. & Young, A. S. (1992). The Epidemiology of Theileriosis in Africa. Academic Press, London.
Ochanda, H. (1994). Factors affecting the population dynamics of Theileria parva in rhipicephalid ticks. Ph.D. thesis, University of Warwick.
Purnell, R. E., Ledger, M. A., Omwoyo, P. L., Payne, R. E. & Peirce, M. A. (1974). Theileria parva: Variation in infection rate of the tick vector Rhipicephahis appendiculatus. International Journal for Parasitology 4, 513517.
Radley, D. E., Brown, C. G. D., Burridge, M. J., Cunningham, M. P., Peirce, M. A. & Purnell, R. E. (1974). East Coast fever: Quantitative studies of Theileria parva in cattle. Experimental Parasitology 36, 278287.
Steel, R. D. & Torrie, J. II. (1980). Principles and Procedures of Statistics: A Biometrical Approach. McGraw Hill, New York.
Wilde, J. K. H. (1967). East Coast fever. Advances in Veterinary Science 11, 207259.
Young, A. S. & Leitch, B. L. (1981 a). Production of Rhipicephalus appendiculatus ticks. Journal of Parasitology 67, 751752.
Young, A. S. & Leitch, D. L. (1981 b). Epidemiology of East Coast fever. Some effects of temperature on the development of Theileria parva in the tick vector Rhipicephalus appendiculatus. Parasitology 83, 199211.
Young, A. S., Leitch, B. L., Irvin, A. D. & Dobbelaire, D. A. E. (1981). The effects of irradiation on the susceptibility of Rhipicephalus appendiculatus ticks to Theileria parva infection. Parasitology 82, 473479.
Young, A. S., Maritim, A. C., Kariuki, D. P., Stagg, D. A., Wafula, J. M., Mutugi, J. J., Cummins, J. M., Richards, A. D. & Burns, C. A. (1990). Low dose oral administration of human interferon alpha can control the development of Theileria parva infection in cattle. Parasitology 101, 201209.
Young, A. S., Dolan, T. T., Mwakima, F. N., Ochand, H., Mwaura, S. N., Njihi, G. M., Muthoni, M. W. & Dolan, R. B. (1995). Estimation of heritability of susceptibility to infection with Theileria parva in the tick Rhipicephalus appendiculatus. Parasitology 111, 3138.

Keywords

Factors influencing infections in Rhipicephalus appendiculatus ticks fed on cattle infected with Theileria parva

  • A. S. Young (a1), T. T. Dolan (a1), S. P. Morzaria (a1), F. N. Mwakima (a1), R. A. I. Norval (a1), J. Scott (a1), A. Sherriff (a2) and G. Gettinby (a2)...

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