Skip to main content Accessibility help
×
Home

Diagnostics for the control and elimination of neglected tropical diseases

  • ROSANNA W. PEELING (a1) and DAVID MABEY (a1)

Summary

Practical diagnostic tools of sufficient sensitivity to detect levels of infection that can lead to transmission have been identified as a critical component of successful disease elimination programmes. In this review we describe the diagnostic tests currently available for six neglected tropical diseases that have been targeted for elimination; assess their performance in the light of the requirements for surveillance, certification of elimination and post-elimination surveillance; consider the unmet need for diagnostic tests for these diseases; and review recent technical developments that could meet these needs.

Copyright

Corresponding author

*Corresponding author: London School of Hygiene and Tropical Medicine, Keppel Street, London SW1E 7HT, UK. E-mail: rosanna.peeling@lshtm.ac.uk

References

Hide All
Al-Awadi, A. R., Al-Kuhlani, A., Breman, J. G., Doumbo, O., Eberhard, M. L., Guiguemde, R. T., Magnussen, P., Molyneux, D. H. and Nadim, A. (2014). Guinea worm (Dracunculiasis) eradication: update on progress and endgame challenges. Transactions of the Royal Society of Tropical Medicine and Hygiene 108, 249251.
Banoo, S., Bell, D., Bossuyt, P., Herring, A., Mabey, D., Poole, F., Smith, P. G., Sriram, N., Wongsrichanalai, C., Linke, R., O'Brien, R., Perkins, M., Cunningham, J., Matsoso, P., Nathanson, C. M., Olliaro, P., Peeling, R. W., Ramsay, A. and TDR Diagnostics Evaluation Expert Panel (2006). Evaluation of diagnostic tests for infectious diseases: general principles. Nature Reviews Microbiology 4 (Suppl.), S21S31.
Bhattacharyya, T., Boelaert, M. and Miles, M. A. (2013). Comparison of visceral leishmaniasis diagnostic antigens in African and Asian Leishmania donovani reveals extensive diversity and region-specific polymorphisms. PLOS Neglected Tropical Diseases 7, e2057.
Boehme, C. C., Nicol, M. P., Nabeta, P., Michael, J. S., Gotuzzo, E., Tahirli, R., Gler, M. T., Blakemore, R., Worodria, W., Gray, C., Huang, L., Caceres, T., Mehdiyev, R., Raymond, L., Whitelaw, A., Sagadevan, K., Alexander, H., Albert, H., Cobelens, F., Cox, H., Alland, D., Perkins, M. D. (2011). Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. Lancet 377, 14951505.
Chappuis, F., Loutan, L., Simarro, P., Lejon, V. and Büscher, P. (2005). Options for field diagnosis of human African trypanosomiasis. Clinical Microbiology Reviews 18, 133146.
Chappuis, F., Sundar, S., Hailu, A., Ghalib, H., Rijal, S., Peeling, R. W., Alvar, J. and Boelaert, M. (2010). Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? Nature Reviews Microbiology 5, 873882.
Chin, C. D., Lakasanasopin, L., Cheung, Y. K., Steinmiller, D., Linder, V., Parsa, H., Wang, J., Moore, H., Rouse, R., Umviligihozo, G., Karita, E., Mwambarangwe, L., Braunstein, S. L., van de Wijgert, J., Sahabo, R., Justman, J. E., El-Sadr, W. and Sia, S. K. (2011). Microfluidics-based diagnostics of infectious diseases in the developing world. Nature Medicine 17, 10151019.
Chu, B. K., Deming, M., Biritwum, N-K., Bougma, W. R., Dorkenoo, A. M., El-Setouhy, M., Fischer, P. U., Gass, K., Gonzalez de Peña, M., Mercado-Hernandez, L., Kyelem, D., Lammie, P. J., Flueckiger, R. M., Mwingira, U. J., Noordin, R., Offei Owusu, I., Ottesen, E. A., Pavluck, A., Pilotte, N., Rao, R. U., Samarasekera, D., Schmaedick, M. A., Settinayake, S., Simonsen, P. E., Supali, T., Taleo, F., Torres, M., Weil, G. J. and Won, K. Y. (2013). Transmission Assessment Surveys (TAS) to define endpoints for lymphatic filariasis mass drug administration: a multicenter evaluation. PLOS Neglected Tropical Diseases 7, e2584.
Cunningham, J., Hasker, E., Das, P., El Safi, S., Goto, H., Mondal, D., Mbuchi, M., Mukhtar, M., Rabello, A., Rijal, S., Sundar, S., Wasunna, M., Adams, E., Menten, J., Peeling, R., Boelaert, M. (2012). A global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis. Clinical Infectious Diseases 55, 13121319.
Dowdle, W. R. (1998). The principles of disease elimination and eradication. Bulletin of the World Health Organization 76 (Suppl. 2), 2225.
Drain, P. K., Hyle, E. P., Noubary, F., Freedberg, K. A., Wilson, D., Bishai, W. R., Rodriguez, W. and Bassett, I. V. (2014). Diagnostic point-of-care tests in resource-limited settings. Lancet Infectious Diseases 14, 239249.
Fung, M. S., Xiao, N., Wang, S. and Carlton, E. J. (2012). Field evaluation of a PCR test for Schistosoma japonicum egg detection in low-prevalence regions of China. American Journal of Tropical Medicine and Hygiene 87, 10531058.
Gao, Y., Lam, A. W. Y. and Chan, W. C. W. (2013). Automating quantum dot barcode assays using microfluidics and magnetism for the development of a point-of-care device. ACS Applied Materials and Interfaces 5, 28532860.
Giri, S., Sykes, E. A., Jennings, T. L. and Chan, W. C. W. (2011). Rapid screening of genetic biomarkers of infectious agents using quantum dot barcodes. ACS Nano 5, 15801587.
Goodhew, E. B., Priest, J. W., Moss, D. M., Zhong, G., Munoz, B., Mkocha, H., Martin, D. L., West, S. K., Gaydos, C. and Lammie, P. J. (2012). CT694 and pgp3 as serological tools for monitoring trachoma programs. PLOS Neglected Tropical Diseases 6, e1873.
Gopal, H., Hassan, H. K., Rodrıguez-Perez, M. A., Toe, L. D., Lustigman, S. and Unnasch, T. R. (2012). Oligonucleotide based magnetic bead capture of Onchocerca volvulus DNA for PCR pool screening of vector black flies. PLOS Neglected Tropical Diseases 6, e1712.
Harding-Esch, E. M., Sillah, A., Edwards, T., Burr, S. E., Hart, J. D., Joof, H., Laye, M., Makalo, P., Manjang, A., Molina, S., Sarr-Sissoho, I., Quinn, T. C., Lietman, T., Holland, M. J., Mabey, D., West, S. K. and Bailey, R., on behalf of the Partnership for Rapid Elimination of Trachoma (PRET) study group (2013). Mass treatment with azithromycin for trachoma: when is one round enough? Results from the PRET trial in The Gambia. PLOS Neglected Tropical Diseases 7, e2115.
Inojosa, W. O., Augusto, I., Bisoffi, Z., Josenado, T., Abel, P. M., Stich, A. and Whitty, C. J. (2006). Diagnosing human African trypanosomiasis in Angola using a card agglutination test: observational study of active and passive case finding strategies. British Medical Journal 332, 1479.
Jani, I. V. and Peter, T. F. (2013). How point-of-care testing could drive innovation in global health. New England Journal of Medicine 368, 23192324.
Mabey, D., Peeling, R. W., Ustianowski, A. and Perkins, M. D. (2004). Diagnostics for the developing world. Nature Reviews Microbiology 2, 231240.
Mitashi, P., Hasker, E., Ngoyi, D. M., Pyana, P. P., Lejon, V., Van der Veken, W., Lutumba, P., Büscher, P., Boelaert, M. and Deborggraeve, S. (2013). Diagnostic accuracy of loopamp Trypanosoma brucei detection kit for diagnosis of human African trypanosomiasis in clinical samples. PLOS Neglected Tropical Diseases 7, e2504.
Niemz, A., Ferguson, T. M. and Boyle, D. S. (2011). Point-of-care nucleic acid testing for infectious diseases. Trends in Biotechnology 29, 240250.
Oguttu, D., Byamukama, E., Katholi, C. R., Habomugisha, P., Nahabwe, C., Ngabirano, M., Hassan, H. K., Lakwo, T., Katabarwa, M., Richards, F. O. and Unnasch, T. R. (2014). Serosurveillance to monitor onchocerciasis elimination: the Ugandan experience. American Journal of Tropical Medicine and Hygiene 90, 339345.
Peeling, R. W. and Mabey, D. (2010). Point-of-care tests for diagnosing infections in the developing world. Microbiology and Infection 16, 10621069.
Roberts, C. H., Last, A., Molina-Gonzalez, S., Cassama, E., Butcher, R., Nabicassa, M., McCarthy, E., Burr, S. E., Mabey, D. C., Bailey, R. L. and Holland, M. J. (2013). Development and evaluation of a next-generation digital PCR diagnostic assay for ocular Chlamydia trachomatis infections. Journal of Clinical Microbiology 51, 21952203.
Solomon, A. W., Holland, M. J., Burton, M. J., West, S. K., Alexander, N. D. E., Aguirre, A., Massae, P. A., Mkocha, H., Munoz, B., Johnson, G. J., Peeling, R. W., Bailey, R. L., Foster, A. and Mabey, D. C. W. (2003). Strategies for control of trachoma: observational study with quantitative PCR. Lancet 362, 198204.
Solomon, A. W., Foster, A. and Mabey, D. C. W. (2006). Clinical examination versus Chlamydia trachomatis assays to guide antibiotic use in trachoma control programmes. Lancet Infectious Diseases 6, 56.
Solomon, A. W., Engels, D., Bailey, R. L., Blake, I. M., Brooker, S., Chen, J-X., Chen, J.-H., Churcher, T. S., Drakeley, C. J., Edwards, T., Fenwick, A., French, M., Gabrielli, A. F., Grassly, N. C., Harding-Esch, E. M., Holland, M. J., Koukounari, A., Lammie, P. J., Leslie, J., Mabey, D. C., Rhajaoui, M., Secor, W. E., Stothard, J. R., Wei, H., Willingham, A. L., Zhou, X-N. and Peeling, R. W. (2012). A diagnostics platform for the integrated mapping, monitoring, and surveillance of neglected tropical diseases: rationale and target product profiles. PLOS Neglected Tropical Diseases 6, e1746.
Sousa-Figueiredo, J. C., Betson, M., Kabatereine, N. B. and Stothard, J. R. (2013). The urine circulating cathodic antigen (CCA) dipstick: a valid substitute for microscopy for mapping and point-of-care diagnosis of intestinal schistosomiasis. PLOS Neglected Tropical Diseases 7, e2008.
Tsang, V. C. and Wilkins, P. P. (1991). Immunodiagnosis of schistosomiasis: screen with FAST-ELISA and confirm with immunoblot. Clinics in Laboratory Medicine 11, 10291039.
Verma, S., Avishek, K., Sharma, V., Negi, N. S., Ramesh, V. and Salotra, P. (2013). Application of loop-mediated isothermal amplification assay for the sensitive and rapid diagnosis of visceral leishmaniasis and post-kala-azar dermal leishmaniasis. Diagnostic Microbiology and Infectious Disease 75, 390395.
Wastling, S. L., Picozzi, K., Wamboga, C., von Wissmann, B., Amongi-Accup, C., Wardrop, N. A., Stothard, J. R., Kakembo, A. and Welburn, S. C. (2011). Latent Trypanosoma brucei gambiense foci in Uganda: a silent epidemic in children and adults? Parasitology 138, 14801487.
World Health Organization. (2001). Criteria for certification of interruption of transmission/elimination of human onchocerciasis. WHO/CDS/CPE/CEE/2001.18a. World Health Organization, Geneva.
Xu, J., Feng, T., Lin, D. D., Wang, Q. Z., Tang, L., Wu, X. H., Guo, J. G., Peeling, R. W. and Zhou, X. N. (2011). Performance of a dipstick dye immunoassay for rapid screening of Schistosoma japonicum infection in areas of low endemicity. Parasites and Vectors 4, 87.
Zhou, X-N., Xu, J., Chen, H-G., Wang, T-P., Huang, X-B., Lin, D-D., Wang, Q-Z., Tang, L., Guo, J-G., Wu, X-H., Feng, T., Chen, J-X., Guo, J., Chen, S-H., Li, H., Wu, Z-D. and Peeling, R. W. (2011). Tools to support policy decisions related to treatment strategies and surveillance of schistosomiasis japonica towards elimination. PLOS Neglected Tropical Diseases 5, e1408.

Keywords

Related content

Powered by UNSILO

Diagnostics for the control and elimination of neglected tropical diseases

  • ROSANNA W. PEELING (a1) and DAVID MABEY (a1)

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed.