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Diagnostics for the control and elimination of neglected tropical diseases

Published online by Cambridge University Press:  23 September 2014

ROSANNA W. PEELING*
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London SW1E 7HT, UK
DAVID MABEY
Affiliation:
London School of Hygiene and Tropical Medicine, Keppel Street, London SW1E 7HT, UK
*
*Corresponding author: London School of Hygiene and Tropical Medicine, Keppel Street, London SW1E 7HT, UK. E-mail: rosanna.peeling@lshtm.ac.uk

Summary

Practical diagnostic tools of sufficient sensitivity to detect levels of infection that can lead to transmission have been identified as a critical component of successful disease elimination programmes. In this review we describe the diagnostic tests currently available for six neglected tropical diseases that have been targeted for elimination; assess their performance in the light of the requirements for surveillance, certification of elimination and post-elimination surveillance; consider the unmet need for diagnostic tests for these diseases; and review recent technical developments that could meet these needs.

Type
Special Issue Article
Copyright
Copyright © Cambridge University Press 2014 

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References

REFERENCES

Al-Awadi, A. R., Al-Kuhlani, A., Breman, J. G., Doumbo, O., Eberhard, M. L., Guiguemde, R. T., Magnussen, P., Molyneux, D. H. and Nadim, A. (2014). Guinea worm (Dracunculiasis) eradication: update on progress and endgame challenges. Transactions of the Royal Society of Tropical Medicine and Hygiene 108, 249251.CrossRefGoogle ScholarPubMed
Banoo, S., Bell, D., Bossuyt, P., Herring, A., Mabey, D., Poole, F., Smith, P. G., Sriram, N., Wongsrichanalai, C., Linke, R., O'Brien, R., Perkins, M., Cunningham, J., Matsoso, P., Nathanson, C. M., Olliaro, P., Peeling, R. W., Ramsay, A. and TDR Diagnostics Evaluation Expert Panel (2006). Evaluation of diagnostic tests for infectious diseases: general principles. Nature Reviews Microbiology 4 (Suppl.), S21S31.CrossRefGoogle ScholarPubMed
Bhattacharyya, T., Boelaert, M. and Miles, M. A. (2013). Comparison of visceral leishmaniasis diagnostic antigens in African and Asian Leishmania donovani reveals extensive diversity and region-specific polymorphisms. PLOS Neglected Tropical Diseases 7, e2057.Google Scholar
Boehme, C. C., Nicol, M. P., Nabeta, P., Michael, J. S., Gotuzzo, E., Tahirli, R., Gler, M. T., Blakemore, R., Worodria, W., Gray, C., Huang, L., Caceres, T., Mehdiyev, R., Raymond, L., Whitelaw, A., Sagadevan, K., Alexander, H., Albert, H., Cobelens, F., Cox, H., Alland, D., Perkins, M. D. (2011). Feasibility, diagnostic accuracy, and effectiveness of decentralised use of the Xpert MTB/RIF test for diagnosis of tuberculosis and multidrug resistance: a multicentre implementation study. Lancet 377, 14951505.Google Scholar
Chappuis, F., Loutan, L., Simarro, P., Lejon, V. and Büscher, P. (2005). Options for field diagnosis of human African trypanosomiasis. Clinical Microbiology Reviews 18, 133146.Google Scholar
Chappuis, F., Sundar, S., Hailu, A., Ghalib, H., Rijal, S., Peeling, R. W., Alvar, J. and Boelaert, M. (2010). Visceral leishmaniasis: what are the needs for diagnosis, treatment and control? Nature Reviews Microbiology 5, 873882.Google Scholar
Chin, C. D., Lakasanasopin, L., Cheung, Y. K., Steinmiller, D., Linder, V., Parsa, H., Wang, J., Moore, H., Rouse, R., Umviligihozo, G., Karita, E., Mwambarangwe, L., Braunstein, S. L., van de Wijgert, J., Sahabo, R., Justman, J. E., El-Sadr, W. and Sia, S. K. (2011). Microfluidics-based diagnostics of infectious diseases in the developing world. Nature Medicine 17, 10151019.Google Scholar
Chu, B. K., Deming, M., Biritwum, N-K., Bougma, W. R., Dorkenoo, A. M., El-Setouhy, M., Fischer, P. U., Gass, K., Gonzalez de Peña, M., Mercado-Hernandez, L., Kyelem, D., Lammie, P. J., Flueckiger, R. M., Mwingira, U. J., Noordin, R., Offei Owusu, I., Ottesen, E. A., Pavluck, A., Pilotte, N., Rao, R. U., Samarasekera, D., Schmaedick, M. A., Settinayake, S., Simonsen, P. E., Supali, T., Taleo, F., Torres, M., Weil, G. J. and Won, K. Y. (2013). Transmission Assessment Surveys (TAS) to define endpoints for lymphatic filariasis mass drug administration: a multicenter evaluation. PLOS Neglected Tropical Diseases 7, e2584.CrossRefGoogle ScholarPubMed
Cunningham, J., Hasker, E., Das, P., El Safi, S., Goto, H., Mondal, D., Mbuchi, M., Mukhtar, M., Rabello, A., Rijal, S., Sundar, S., Wasunna, M., Adams, E., Menten, J., Peeling, R., Boelaert, M. (2012). A global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis. Clinical Infectious Diseases 55, 13121319.CrossRefGoogle ScholarPubMed
Dowdle, W. R. (1998). The principles of disease elimination and eradication. Bulletin of the World Health Organization 76 (Suppl. 2), 2225.Google ScholarPubMed
Drain, P. K., Hyle, E. P., Noubary, F., Freedberg, K. A., Wilson, D., Bishai, W. R., Rodriguez, W. and Bassett, I. V. (2014). Diagnostic point-of-care tests in resource-limited settings. Lancet Infectious Diseases 14, 239249.Google Scholar
Fung, M. S., Xiao, N., Wang, S. and Carlton, E. J. (2012). Field evaluation of a PCR test for Schistosoma japonicum egg detection in low-prevalence regions of China. American Journal of Tropical Medicine and Hygiene 87, 10531058.CrossRefGoogle ScholarPubMed
Gao, Y., Lam, A. W. Y. and Chan, W. C. W. (2013). Automating quantum dot barcode assays using microfluidics and magnetism for the development of a point-of-care device. ACS Applied Materials and Interfaces 5, 28532860.Google Scholar
Giri, S., Sykes, E. A., Jennings, T. L. and Chan, W. C. W. (2011). Rapid screening of genetic biomarkers of infectious agents using quantum dot barcodes. ACS Nano 5, 15801587.CrossRefGoogle ScholarPubMed
Goodhew, E. B., Priest, J. W., Moss, D. M., Zhong, G., Munoz, B., Mkocha, H., Martin, D. L., West, S. K., Gaydos, C. and Lammie, P. J. (2012). CT694 and pgp3 as serological tools for monitoring trachoma programs. PLOS Neglected Tropical Diseases 6, e1873.Google Scholar
Gopal, H., Hassan, H. K., Rodrıguez-Perez, M. A., Toe, L. D., Lustigman, S. and Unnasch, T. R. (2012). Oligonucleotide based magnetic bead capture of Onchocerca volvulus DNA for PCR pool screening of vector black flies. PLOS Neglected Tropical Diseases 6, e1712.Google Scholar
Harding-Esch, E. M., Sillah, A., Edwards, T., Burr, S. E., Hart, J. D., Joof, H., Laye, M., Makalo, P., Manjang, A., Molina, S., Sarr-Sissoho, I., Quinn, T. C., Lietman, T., Holland, M. J., Mabey, D., West, S. K. and Bailey, R., on behalf of the Partnership for Rapid Elimination of Trachoma (PRET) study group (2013). Mass treatment with azithromycin for trachoma: when is one round enough? Results from the PRET trial in The Gambia. PLOS Neglected Tropical Diseases 7, e2115.CrossRefGoogle ScholarPubMed
Inojosa, W. O., Augusto, I., Bisoffi, Z., Josenado, T., Abel, P. M., Stich, A. and Whitty, C. J. (2006). Diagnosing human African trypanosomiasis in Angola using a card agglutination test: observational study of active and passive case finding strategies. British Medical Journal 332, 1479.Google Scholar
Jani, I. V. and Peter, T. F. (2013). How point-of-care testing could drive innovation in global health. New England Journal of Medicine 368, 23192324.Google Scholar
Mabey, D., Peeling, R. W., Ustianowski, A. and Perkins, M. D. (2004). Diagnostics for the developing world. Nature Reviews Microbiology 2, 231240.Google Scholar
Mitashi, P., Hasker, E., Ngoyi, D. M., Pyana, P. P., Lejon, V., Van der Veken, W., Lutumba, P., Büscher, P., Boelaert, M. and Deborggraeve, S. (2013). Diagnostic accuracy of loopamp Trypanosoma brucei detection kit for diagnosis of human African trypanosomiasis in clinical samples. PLOS Neglected Tropical Diseases 7, e2504.Google Scholar
Niemz, A., Ferguson, T. M. and Boyle, D. S. (2011). Point-of-care nucleic acid testing for infectious diseases. Trends in Biotechnology 29, 240250.Google Scholar
Oguttu, D., Byamukama, E., Katholi, C. R., Habomugisha, P., Nahabwe, C., Ngabirano, M., Hassan, H. K., Lakwo, T., Katabarwa, M., Richards, F. O. and Unnasch, T. R. (2014). Serosurveillance to monitor onchocerciasis elimination: the Ugandan experience. American Journal of Tropical Medicine and Hygiene 90, 339345.Google Scholar
Peeling, R. W. and Mabey, D. (2010). Point-of-care tests for diagnosing infections in the developing world. Microbiology and Infection 16, 10621069.Google Scholar
Roberts, C. H., Last, A., Molina-Gonzalez, S., Cassama, E., Butcher, R., Nabicassa, M., McCarthy, E., Burr, S. E., Mabey, D. C., Bailey, R. L. and Holland, M. J. (2013). Development and evaluation of a next-generation digital PCR diagnostic assay for ocular Chlamydia trachomatis infections. Journal of Clinical Microbiology 51, 21952203.Google Scholar
Solomon, A. W., Holland, M. J., Burton, M. J., West, S. K., Alexander, N. D. E., Aguirre, A., Massae, P. A., Mkocha, H., Munoz, B., Johnson, G. J., Peeling, R. W., Bailey, R. L., Foster, A. and Mabey, D. C. W. (2003). Strategies for control of trachoma: observational study with quantitative PCR. Lancet 362, 198204.CrossRefGoogle ScholarPubMed
Solomon, A. W., Foster, A. and Mabey, D. C. W. (2006). Clinical examination versus Chlamydia trachomatis assays to guide antibiotic use in trachoma control programmes. Lancet Infectious Diseases 6, 56.Google Scholar
Solomon, A. W., Engels, D., Bailey, R. L., Blake, I. M., Brooker, S., Chen, J-X., Chen, J.-H., Churcher, T. S., Drakeley, C. J., Edwards, T., Fenwick, A., French, M., Gabrielli, A. F., Grassly, N. C., Harding-Esch, E. M., Holland, M. J., Koukounari, A., Lammie, P. J., Leslie, J., Mabey, D. C., Rhajaoui, M., Secor, W. E., Stothard, J. R., Wei, H., Willingham, A. L., Zhou, X-N. and Peeling, R. W. (2012). A diagnostics platform for the integrated mapping, monitoring, and surveillance of neglected tropical diseases: rationale and target product profiles. PLOS Neglected Tropical Diseases 6, e1746.CrossRefGoogle ScholarPubMed
Sousa-Figueiredo, J. C., Betson, M., Kabatereine, N. B. and Stothard, J. R. (2013). The urine circulating cathodic antigen (CCA) dipstick: a valid substitute for microscopy for mapping and point-of-care diagnosis of intestinal schistosomiasis. PLOS Neglected Tropical Diseases 7, e2008.Google Scholar
Tsang, V. C. and Wilkins, P. P. (1991). Immunodiagnosis of schistosomiasis: screen with FAST-ELISA and confirm with immunoblot. Clinics in Laboratory Medicine 11, 10291039.Google Scholar
Verma, S., Avishek, K., Sharma, V., Negi, N. S., Ramesh, V. and Salotra, P. (2013). Application of loop-mediated isothermal amplification assay for the sensitive and rapid diagnosis of visceral leishmaniasis and post-kala-azar dermal leishmaniasis. Diagnostic Microbiology and Infectious Disease 75, 390395.Google Scholar
Wastling, S. L., Picozzi, K., Wamboga, C., von Wissmann, B., Amongi-Accup, C., Wardrop, N. A., Stothard, J. R., Kakembo, A. and Welburn, S. C. (2011). Latent Trypanosoma brucei gambiense foci in Uganda: a silent epidemic in children and adults? Parasitology 138, 14801487.Google Scholar
World Health Organization. (2001). Criteria for certification of interruption of transmission/elimination of human onchocerciasis. WHO/CDS/CPE/CEE/2001.18a. World Health Organization, Geneva.Google Scholar
Xu, J., Feng, T., Lin, D. D., Wang, Q. Z., Tang, L., Wu, X. H., Guo, J. G., Peeling, R. W. and Zhou, X. N. (2011). Performance of a dipstick dye immunoassay for rapid screening of Schistosoma japonicum infection in areas of low endemicity. Parasites and Vectors 4, 87.CrossRefGoogle ScholarPubMed
Zhou, X-N., Xu, J., Chen, H-G., Wang, T-P., Huang, X-B., Lin, D-D., Wang, Q-Z., Tang, L., Guo, J-G., Wu, X-H., Feng, T., Chen, J-X., Guo, J., Chen, S-H., Li, H., Wu, Z-D. and Peeling, R. W. (2011). Tools to support policy decisions related to treatment strategies and surveillance of schistosomiasis japonica towards elimination. PLOS Neglected Tropical Diseases 5, e1408.Google Scholar