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Contrasts in antigen expression in the erythrocytic and exoerythrocytic stages of rodent malaria

  • A. Suhrbier (a1), M. F. Wiser (a2), L. Winger (a1), P. Harte (a3), M. F. Newton (a1), K. J. Hodivala (a1), J. Nicholas (a1) and R. E. Sinden (a1)...

Summary

The time and Site of expression of five antigens, recognized by monoclonal antibodies raised against blood-stage parasites, were studied in the exoerythrocytic stage of Plasmodium berghei using indirect immunofluorescent antibody staining. Two monoclonal antibodies (W 3. 5, I 2. 6), which stain the cytoplasm of infected erythrocytes, did not stain the cytoplasm of the infected liver cell but stained the parasite itself suggesting a difference in the antigenic architecture of the erythrocytic and exoerythrocytic parasites. Another antibody (17. 6. 1) revealed a further difference in the antigenic composition of the blood and liver-stage parasites being expressed almost exclusively in the former. Two others (C139 and 17. 3. 9) showed broadly similar patterns of expression in these two stages of the malarial life-cycle.

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Keywords

Contrasts in antigen expression in the erythrocytic and exoerythrocytic stages of rodent malaria

  • A. Suhrbier (a1), M. F. Wiser (a2), L. Winger (a1), P. Harte (a3), M. F. Newton (a1), K. J. Hodivala (a1), J. Nicholas (a1) and R. E. Sinden (a1)...

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