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A comparison of the effects of flubendazole and thiabendazole on the larvae of Angiostrongylus cantonensis, Trichinella spiralis, Diphyllobothrium erinacei and Hymenolepis nana in mice

Published online by Cambridge University Press:  06 April 2009

Jun Maki  and
Toshio Yanagisawa
Jun Maki
Affiliation:
Department of Parasitology, Kitasato University School of Medicine, Sagamihara, 228 Japan
Toshio Yanagisawa
Affiliation:
Department of Parasitology, Kitasato University School of Medicine, Sagamihara, 228 Japan
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Summary

Flubendazole or thiabendazole were administered orally to mice harbouring larvae of Angiostrongylus cantonensis, Trichinella spiralis, Diphyllobothrium erinacei or Hymenolepis nana 5–10, 28–33 and 21–26 and 1–6 days post-infection respectively. All the mice infected with A. cantonensis were completely cured after treatment with flubendazole at 5 mg/kg/day for 6 days. No noticeable damage was found in the cerebral hemispheres of the mice treated with flubendazole and examined under a dissecting microscope. On the other hand, larvae were found in or on the cerebral hemispheres showing obvious haemorrhage in the control mice. The mice treated with flubendazole gained weight while the control mice lost weight. No larvicidal effect of thiabendazole on A. cantonensis was found at a dose of 10 mg/kg/day for 6 days. The mean reduction of larval T. spiralis in mice treated with flubendazole at 5, 50 and 100 mg/kg/day for 6 days was 64, 100 and 99% respectively. In comparison, thiabendazole showed no efficacy against T. spiralis larvae at 50 or 100 mg/kg/day. Mice harbouring plerocercoids of D. erinacei or H. nana larvae were not cured with either flubendazole or thiabendazole at 50 or 100 mg/kg/day for 6 days.

Type
Research Article
Information
Parasitology , Volume 87 , Issue 3 , December 1983 , pp. 525 - 531
Copyright
Copyright © Cambridge University Press 1983

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References

REFERENCES

Alicata, J. E. (1965). Biology and distribution of the rat lungworm, Angiostrongylus cantonensis, and its relationship to eosinophilic meningoencephalitis and other neurological disorders of man and animals. In Advances in Parasitology, vol. 1 (ed. Dawes, B.), pp. 223–48. London and New York: Academic Press.Google Scholar
Mackerras, M. J. & Sandars, D. F. (1955) The life history of the rat lungworm, Angiostrongylus cantonensis (Chen) (Nematoda: Metastrongylidae). Australian Journal of Zoology 3, 1–25.CrossRefGoogle Scholar
Maki, J., Kondo, A. & Yanagisawa, T. (1983) Effects of alcoholic extract from Ma-Klua (Diospyros mollis) on adults and larvae of the dwarf tapeworm, Hymenolepis nana in mice and on the infectivity of the eggs. Parasitology 87, 103–11.CrossRefGoogle ScholarPubMed
Maki, J. & Yanagisawa, T. (1980) Acid phosphatase activity demonstrated in the nematodes, Dirofilaria immitis and Angiostrongylus cantonensis with special reference to the characters and distribution. Parasitology 80, 23–38.CrossRefGoogle Scholar
Novak, M. & Evans, W. S. (1981) Mebendazole and the development of Hymenolepis nana in mice. International Journal for Parasitology 11, 277–80.CrossRefGoogle ScholarPubMed
Tateno, S., Takeuchi, T., Kobayashi, S., Tanabe, M., Miura, S & Asami, K. (1981) Health status of Indo-China refugees in Japan: Prevalence of intestinal parasites and eosinophilia. Japanese Journal of Parasitology 30, 485–96.Google Scholar
Telléz-Girón, E., Ramos, M. C. & Montante, M. (1981) Effect of flubendazole on Cysticercus cellulosae in pigs. American Journal of Tropical Medicine and Hygiene 30, 135–8.CrossRefGoogle ScholarPubMed
Thienpont, D., Vanparijs, O., Niemegeers, C. & Marsboom, R. (1978) Biological and pharmacological properties of flubendazole. Arzneimittel-Forschung 28, 605–12.Google ScholarPubMed
Vanparijs, O., Hermans, L. & Thienpont, D. (1979) Anthelmintic activity of flubendazole against Trichinella spiralis in rats. Veterinary Parasitology 5, 237–42.CrossRefGoogle Scholar
Verheyen, A., Borgers, M., Vanparijs, O. & Thienpont, D. (1976). The effects of mebendazole on the ultrastructure of cestodes. In Biochemistry of Parasites and Host–Parasite Relationships (ed. Van den Bossche, H.), pp. 605–618. Amsterdam, New York and Oxford: North-Holland Publishing Company.Google Scholar
Yamashita, T., Sato, Y., Shiraki, T., Otsuru, M. & Suzuki, T. (1975) Development of Angiostrongylus cantonensis in rats, mice and guinea pigs. Japanese Journal of Parasitology 24, 114–121. (In Japanese with English summary.)Google Scholar
Yanagisawa, T. (1983). Angiostrongyliasis as a parasitic zoonosis. In Parasitic Zoonoses in Japan (ed. Hayashi, S., Ishii, T., Oshio, Y., Koyama, T. and Kondo, S.), pp. 258–70. Tokyo: Buneido Press. (In Japanese.)Google Scholar