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Can the host immune system promote multiple invasions of erythrocytes in vivo? Differential effects of medication and host sex in a wild malaria-like model

Published online by Cambridge University Press:  04 December 2006

J. MARTÍNEZ-DE LA PUENTE ,
S. MERINO ,
G. TOMÁS ,
J. MORENO ,
J. MORALES ,
E. LOBATO  and
S. GARCÍA-FRAILE
J. MARTÍNEZ-DE LA PUENTE*
Affiliation:
Departamento de Ecología Evolutiva, Museo Nacional de Ciencias Naturales-C.S.I.C., C\ José Gutiérrez Abascal, 2. E-28006 Madrid, Spain
S. MERINO
Affiliation:
Departamento de Ecología Evolutiva, Museo Nacional de Ciencias Naturales-C.S.I.C., C\ José Gutiérrez Abascal, 2. E-28006 Madrid, Spain
G. TOMÁS
Affiliation:
Departamento de Ecología Evolutiva, Museo Nacional de Ciencias Naturales-C.S.I.C., C\ José Gutiérrez Abascal, 2. E-28006 Madrid, Spain
J. MORENO
Affiliation:
Departamento de Ecología Evolutiva, Museo Nacional de Ciencias Naturales-C.S.I.C., C\ José Gutiérrez Abascal, 2. E-28006 Madrid, Spain
J. MORALES
Affiliation:
Departamento de Ecología Evolutiva, Museo Nacional de Ciencias Naturales-C.S.I.C., C\ José Gutiérrez Abascal, 2. E-28006 Madrid, Spain
E. LOBATO
Affiliation:
Departamento de Ecología Evolutiva, Museo Nacional de Ciencias Naturales-C.S.I.C., C\ José Gutiérrez Abascal, 2. E-28006 Madrid, Spain
S. GARCÍA-FRAILE
Affiliation:
Departamento de Ecología Evolutiva, Museo Nacional de Ciencias Naturales-C.S.I.C., C\ José Gutiérrez Abascal, 2. E-28006 Madrid, Spain
*
*Corresponding author. Tel: +34914111328. Fax: +34915645078. E-mail: jmp@mncn.csic.es
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Summary

Multiple invasions (MIs) or infections, i.e. those by more than 1 parasite in the same erythrocyte, could be the result of parasite density or, alternatively, to parasite-related factors or host-related factors. According to the last possibility, to our knowledge, only 3 laboratory studies of malaria have found an increase in the occurrence of MIs when antibodies to parasite antigens were present. Therefore, we tested the possibility that MIs were influenced by the host immune status, using as model the malaria-like parasite Haemoproteus infecting blue tits (Cyanistes caeruleus). Avian hosts infected with Haemoproteus were medicated with primaquine or injected with saline solution and the density of infection and the presence of MIs counted. Medication treatment reduced significantly the density of infection by Haemoproteus in females but not in males. For females, the presence of MIs was positively associated with both the density of infection and the immunoglobulin levels on each capture, but no association was found between the treatment and the presence of MIs. For males, the density of infection but not the immunoglobulin levels was positively associated with the presence of MIs. In addition, medicated males supported more MIs than controls. Our results represent the first line of evidence in the wild for a possible role of the host immune system promoting MIs.

Keywords

multiple invasionshost immunityHaemoproteusPlasmodiumhost-parasite interactionsmalariasexual differences
Type
Research Article
Information
Parasitology , Volume 134 , Issue 5 , May 2006 , pp. 651 - 655
Copyright
Copyright © Cambridge University Press 2006

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