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Recovery of parasites at different stages of migration following infection of rats with Schistosoma mansoni

Published online by Cambridge University Press:  06 April 2009


P. M. Knopf
Affiliation:
Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912
Beverly L. Mangold
Affiliation:
Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912
G. J. Makari
Affiliation:
Division of Biology and Medicine, Brown University, Providence, Rhode Island 02912

Summary

The technique of tail amputation is utilized as a method for interrupting the migration process of Schistosoma mansoni schistosomula from the skin of Fischer rats infected by exposure of the tail to cercariae. The yields of schistosomula recovered from the lungs at different times post-infection are compared, using rats with or without tail amputation. Residence times of schistosomula in skin and lungs, as well as their transit time and efficiency of migration between these sites, are estimated. At least one-third of the infecting cercariae migrate from skin to lung in rats. Amputation of the tail on days 4 or 5 post-infection isolates a definable number of schistosomula in the lung and their migration to the portal circulation can be followed. The kinetics of this migration in rats and mice is compared and a significant difference is revealed.


Type
Research Article
Copyright
Copyright © Cambridge University Press 1983

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