Abbasi, F, McLaughlin, T, Lamendola, C, Lipinska, I, Tofler, G & Raeven, GM (1999) Comparison of plasminogen activator inhibitor-1 concentration in insulin-resistant versus insulin-sensitive healthy women. Arteriosclerosis, Thrombosis and Vascular Biology 19, 2818–2821.
Abe, H, Kawano, Y, Kojima, S, Ashida, T, Kuramochi, M, Matsuoka, H & Omae, T (1994) Biphasic effects of repeated alcohol intake on 24-hour blood pressure in hypertensive patients. Circulation 89, 2626–2633.
Abramson, JL, Williams, SA, Krumholz, HM & Vaccarino, V (2001) Moderate alcohol consumption and risk of heart failure among older persons. Journal of the American Medical Association 285, 1971–1977.
Aguilera, MT, de la Sierra, A, Coca, A, Estruch, R, Fernández-Solá, J & Urbano-Márquez, A (1999) Effect of alcohol abstinence on blood pressure. Assessment by 24-hour ambulatory blood pressure monitoring. Hypertension 33, 653–657.
Ajani, UA, Hennekens, CH, Spelsberg, A & Manson, JE (2000) Alcohol consumption and risk of type 2 diabetes mellitus among US male physicians. Archives of Internal Medicine 160, 1025–1030.
Albert, CM, Manson, JE, Cook, NR, Ajani, UA, Gaziano, M & Hennekens, CH (1999) Moderate alcohol consumption and the risk of sudden cardiac death among US male physicians. Circulation 100, 944–950.
Algra, A, Tijssen, JG, Roelandt, JR, Pool, J & Lubsen, J (1993) Heart rate variability from 24-hour electrocardiography and the 2-years risk for sudden death. Circulation 88, 180–185.
Anonymous, (1987) Moderate alcohol consumption increases plasma high-density lipoprotein cholesterol. Nutrition Reviews 45, 8–10.
Arkwright, PD, Beilen, LJ, Rouse, I, Armstrong, BK & Vandongen, R (1982) Effects of alcohol use and other aspects of lifestyle on blood pressure levels and prevalence of hypertension in a working population. Circulation 66, 60–66.
Armellini, F, Zamboni, M, Frigo, L, Mandragona, R, Robbi, R, Micciolo, R & Bosello, O (1993) Alcohol consumption, smoking habits and body fat distribution in Italian men and women aged 20–60 years. European Journal of Clinical Nutrition 47, 52–60.
Avogaro, A, Fontana, P, Valerio, A, Trevisan, R, Riccio, A, Del Prato, S, Nosadini, R, Tiengo, A & Crepaldi, G (1987) Alcohol impairs insulin sensitivity in normal subjects. Diabetes Research 5, 23–27.
Baraona, E & Lieber, CS (1979) Effects of ethanol on lipid metabolism. Journal of Lipid Research 20, 289–315.
Bell, RA, Mayer-Davis, E, Martin, MA, D'Agostino, RB & Haffner, SM (2000) Associations between alcohol consumption and insulin sensitivity and cardiovascular disease risk factors. Diabetes Care 23, 1630–1636.
Berliner, JA, Navab, M, Fogelman, AM, Frank, JS, Demer, LL, Edwards, PA, Watson, AD & Lusis, AJ (1995) Atherosclerosis: Basic mechanisms. Oxidation, inflammation, and genetics. Circulation 91, 2488–2496.
Bierenbaum, ML, Struck, ML, Tomeo, AC, Halley, J & Watkins, TR (1994) Effect of red and white wine on serum|lipids, platelet aggregation, oxidation products and antioxidants. Clinical Research. 157A Abstr.
Bobak, M, Skodova, Z & Marmot, M (2000) Effect of beer drinking on risk of myocardial infarction: population based case–control study. British Medical Journal 320, 1378–1379.
Bourne, L, Paganga, G, Baxter, D, Hughes, P & Rice-Evans, C (2000) Absorption of ferulic acid from low-alcohol beer. Free Radical Research 32, 273–280.
Brattstöm, L & Wilcken, DEL (2000) Homocysteine and cardiovascular disease: cause or effect?. American Journal of Clinical Nutrition 72, 315–323.
Brenn, T (1986) The Tromsø heart study: alcoholic beverage and coronary risk factors. Journal of Epidemiology and Community Health 40, 249–256.
Burr, ML, Fehily, AM, Butland, BK, Bolton, CH & Eastham, RD (1986) Alcohol and high-density-lipoprotein cholesterol: a randomized controlled trial. British Journal of Nutrition 56, 81–86.
Cao, G, Russell, RM, Lischner, N & Prior, RL (1998) Serum antioxidant capacity is increased by consumption of strawberries, spinach, red wine or vitamin C in elderly women. Journal of Nutrition 128, 2383–2390.
Casassus, P, Fontbonne, A, Thibult, N, Ducimetière, P, Richard, JL, Claude, J-R, Warnet, J-M, Rosselin, G & Eschwège, E (1992) Upper body fat distribution: A hyperinsulinemia-independent predictor of coronary heart disease mortality. The Paris prospective study. Arteriosclerosis and Thrombosis 12, 1387–1392.
Chan, MM-Y, Mattiacci, JA, Hwang, HS, Shah, A & Fong, D (2000) Synergy between ethanol and grape polyphenols, quercetin, and|resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Biochemical Pharmacology 60, 1539–1548.
Chen, F, Lu, Y, Demers, LM, Rojanasakul, Y, Shi, X, Vallyathan, V & Castranova, V (1998) Role of hydroxyl radical in silica-induced NF-κB activation in macrophages. Annals of Clinical and Laboratory Science 28, 1–13.
Cigolini, M, Seidell, JC, Targher, G, Deslypere, JP, Éllsinger, BM, Charzewska, J, Cruz, A & Björntorp, P (1995) Fasting serum insulin in relation to components of the metabolic syndrome in European healthy men: The European Fat Distribution Study. Metabolism 44, 35–40.
Cigolini, M, Targher, G, Andreis, IAB, Tonoli, M, Filippi, F, Muggeo, M & De Sandre, G (1996) Moderate alcohol consumption and its relation to visceral fat and plasma androgens in healthy women. International Journal of Obesity and Related Disorders 20, 206–212.
Cleophas, TJ (1999) Wine, beer and spirits and the risk of myocardial infarction: a systematic review. Biomedicine and Pharmacotherapy 53, 417–423.
Cleophas, TJ, Hornstra, N, van Hoogstraten, B & van der Meulen, J (2000) Homocysteine, a risk factor for coronary artery disease or not? A meta-analysis. American Journal of Cardiology 86, 1005–1009.
Cook, NR, Cohen, J, Herbert, PR, Taylor, JO & Hennekens, CH (1995) Implications of small reductions in diastolic blood pressure for primary prevention. Archives of Internal Medicine 155, 701–709.
Cooke, KM, Frost, G & Stokes, GS (1983) Blood pressure and its relationship to low levels of alcohol consumption. Clinical and Experimental Pharmacology and Physiology 10, 229–233.
Cordain, L, Bryan, ED, Melby, CL & Smith, MJ (1997) Influence of moderate daily wine consumption on body weight regulation and metabolism in healthy free-living males. Journal of the American College of Nutrition 16, 134–139.
Cordain, L, Melby, CL, Hamamoto, AE, O Neill, DS, Cornier, MA, Barakat, HA, Israel, RG & Hill, JO (2000) Influence of moderate chronic wine consumption on insulin sensitivity and other correlates of syndrome X in moderately obese women. Metabolism 49, 1473–1478.
Couzigou, P, Fleury, B, Crockett, R, Rautou, JJ, Blanchard, P, Lemoine, F, Richard-Molard, B & Béraud, C (1984) High density lipoprotein cholesterol and apoprotein A1 in healthy volunteers during long-term moderate alcohol intake. Annals of Nutrition and Metabolism 28, 377–384.
Crouse, JR & Grundy, SM (1984) Effects of alcohol on plasma lipoproteins and cholesterol and triglyceride metabolism in man. Journal of Lipid Research 25, 486–496.
Cuevas, AM, Guasch, V, Castillo, O, Irribarra, V, Mizon, C, San Martin, A, Strobel, P, Perez, D, Germain, AM & Leighton, F (2000) A high-fat diet induces and red wine counteracts endothelial dysfunction in human volunteers. Lipids 35, 143–148.
Demrow, HS, Slane, PR & Folts, JD (1995) Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation 91, 1182–1188.
Diaz, MN, Frei, B, Vita, JA & Keaney, JF (1997) Antioxidants and atherosclerotic heart disease. New England Journal of Medicine 337, 408–416.
Dimmitt, SB, Rakic, V, Puddey, IB, Baker, R, Oostryck, R, Adams, MJ, Chesterman, CN, Burke, V & Beilin, LJ (1998) The effect of alcohol on coagulation and fibrinolytic factors: a controlled trial. Blood Coagulation and Fibrinolysis 9, 39–45.
Fenn, CG & Littleton, JM (1982) Inhibition of platelet aggregation by ethanol in vitro shows specificity for aggregating agent used and is influenced by platelet lipid composition. Thrombosis and Haemostasis 48, 49–53.
Fitzpatrick, DF, Hirschfield, SL & Coffey, RG (1993) Endothelium-dependent vasorelaxing activity of wine and other grape products. American Journal of Physiology 265, H774–H778.
Flanagan, DEH, Moore, VM, Godsland, IF, Cockington, RA, Robinson, JS & Phillips, DI (2000) Alcohol consumption and insulin resistance in young adults. European Journal of Clinical Investigation 30, 297–301.
Flesch, M, Schwarz, A & Böhm, M (1998) Effects of red and white wine on endothelial-dependent vasorelaxation of rat aorta and human coronary arteries. American Journal of Physiology 275, H1183–H1190.
Frankel, EN, Kanner, J, German, JB, Parks, E & Kinsella, JE (1993) Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 341, 454–457.
Fuhrman, B, Lavy, A & Aviram, M (1995) Consumption of red wine with meals reduces the susceptibility of human plasma and low-density lipoprotein to lipid peroxidation. American Journal of Clinical Nutrition 61, 549–554.
Fumeron, F, Betoulle, D, Luc, G, Behague, I, Ricard, S, Poirier, O, Jemaa, R, Evans, A, Arveiler, D, Marques-Vidal, P, Bard, J-M, Fruchart, J-C, Ducimetière, P, Apfelbaum, M & Cambien, F (1995) Alcohol intake modulates the effect of polymorphism of the cholesteryl ester transfer protein gene on plasma high density lipoprotein and risk of myocardial infarction. Journal of Clinical Investigation 96, 1664–1671.
Gasbarrini, A, Addolorato, G, Simoncini, M, Gasbarrini, G, Fantozzi, P, Mancini, F, Montanari, L, Nardini, M, Ghiselli, A & Scaccini, C (1998) Beer affects oxidative stress due to ethanol in rats. Digestive Diseases and Science 43, 1332–1338.
Gaziano, JM, Buring, JE, Breslow, JL, Goldhaber, SZ, Rosner, B, VanDenburgh, M, Willet, W & Hennekens, CH (1993) Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. New England Journal of Medicine 329, 1829–1834.
Gaziano, JM, Hennekens, CH, Godfried, SL, Sesso, HD, Glynn, RJ, Breslow, JL & Buring, JE (1999) Type of alcoholic beverage and risk of myocardial infarction. American Journal of Cardiology 83, 52–57.
Ghiselli, A, Nardini, M, Baldi, A & Scaccini, C (1998) Antioxidant activity of different phenolic fractions separated from an Italian red wine. Journal of Agricultural and Food Chemistry 46, 361–367.
Ghiselli, A, Natella, F, Guidi, A, Montanri, L, Fantozzi, P & Scaccini, C (2000) Beer increases plasma antioxidant capacity in humans. Journal of Nutritional Biochemistry 11, 76–80.
Gillman, MW, Cook, NR, Evans, DA, Rosner, B & Hennekens, CH (1995) Relationship of alcohol intake with blood pressure in young adults. Hypertension 25, 1106–1110.
Gordon, T, Ernst, N, Fisher, M & Rifkind, BM (1981) Alcohol and high-density lipoprotein cholesterol. Circulation 64,Suppl. III, 63–67.
Gorinstein, S, Zemser, M, Berliner, M, Goldstein, R, Libman, I, Trakhtenberg, S & Caspi, A (1997 a) Moderate beer consumption and positive biochemical changes in patients with coronary atherosclerosis. Journal of Internal Medicine 242, 219–224.
Gorinstein, S, Zemser, M, Lichman, I, Berebi, A, Kleipfish, A, Libman, I, Trakhtenberg, S & Caspi, A (1997 b) Moderate beer consumption and the blood coagulation in patients with coronary artery disease. Journal of Internal Medicine 241, 47–51.
Greenspon, AJ & Schaal, SF (1983) The holiday heart: electrophysiologic studies of alcohol effects in alcoholics. Annals of Internal Medicine 98, 135–139.
Grønbæk, M, Deis, A, Sørensen, TIA, Becker, U, Borch-Johansen, K, Müller, C, Schnohr, P & Jensen, G (1994) Influence of sex, age, body mass index, and smoking on alcohol intake and mortality. British Medical Journal 308, 302–306.
Grønbæk, M, Deis, A, Sørensen, TIA, Becker, U, Schnohr, P & Jensen, G (1995) Mortality associated with moderate intakes of wine, beer, or spirits. British Medical Journal 310, 1165–1169.
Grundy, SM (2001) Non-high-density lipoprotein cholesterol level as potential risk predictor and therapy target. Archives of Internal Medicine 161, 1379–1380.
Gryglewski, RJ, Palmer, RM & Moncada, S (1986) Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 320, 454–456.
Hagiage, M, Marti, C, Rigaud, D, Senault, C, Fumeron, F, Apfelbaum, M & Girard-Globa, A (1992) Effect of moderate alcohol intake on the lipoproteins of normotriglyceridemic obese subject compared with normoponderal controls. Metabolism 41, 856–861.
Hagstrup Christensen, J, Skou, AS, Fog, L, Ellegaard Hansen, V, Vesterlund, T, Dyerberg, J, Toft, E & Berg Schmidt, E (2001) Marine n-3 fatty|acids, wine intake, and heart rate variability in patients referred for coronary angiography. Circulation 103, 651–657.
Handa, K, Kono, S, Ishii, H, Shinchi, K, Imanishi, K & Arakawa, K (1994) Relationship of alcohol consumption and smoking to plasma cortisol and blood pressure. Journal of Human Hypertension 8, 891–894.
Hartung, GH, Foreyt, JP, Mitchell, RE, Mitchell, JG, Reeves, RS & Gotto, AM (1983) Effects of alcohol intake on high-density lipoprotein cholesterol levels in runners and inactive men. Journal of the American Medical Association 249, 747–750.
Hartung, GH, Foreyt, JP, Reeves, RS, Krock, LP, Patsch, W, Patsch, JR & Gotto, AM (1990) Effect of alcohol dose on plasma lipoprotein subfractions and lipolytic enzyme activity in active and inactive men. Metabolism 39, 81–86.
Haskell, WL, Camargo, C, Williams, PT, Vranizan, KM, Krauss, RM, Lindgren, FT & Wood, PD (1984) The effect of cessation and resumption of moderate alcohol intake on serum high-density-lipoprotein subfractions. New England Journal of Medicine 310, 805–810.
Heery, JM, Kozak, M, Stafforini, DM, Jones, DA, Zimmerman, GA & McIntyre, TM (1995) Oxidatively modified LDL contains phospholipids with platelet-activating factor-like activity and stimulates the growth of smooth muscle cells. Journal of Clinical Investigation 96, 2322–2330.
Hein, HO, Suadicani, P & Gyntelberg, F (1996) Alcohol consumption, serum low density lipoprotein cholesterol concentration, and risk of ischaemic heart disease: six year follow up in the Copenhagen male study. British Medical Journal 312, 736–741.
Hendriks, HF, Veenstra, J, Van Tol, A, Groener, JEM & Schaafsma, G (1998) Moderate doses of alcoholic beverages with dinner and postprandial high density lipoprotein composition. Alcohol and Alcoholism 33, 403–410.
Hendriks, HFJ, Veenstra, J, Wierik, EJMV, Schaafsma, G & Kluft, C (1994) Effect of moderate dose of alcohol with evening meal on fibrinolytic factors. British Medical Journal 308, 1003–1006.
Hertog, MGL, Feskens, EJM, Hollman, PCH, Katan, MB & Kromhout, D (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342, 1007–1011.
Hertog, MGL, Kromhout, D, Aravanis, C, Blackburn, H, Buzina, R, Fidanza, F, Giampaoli, S, Jansen, A, Menotti, A, Nedeljkovic, S, Pekkarinen, M, Simic, BS, Toshima, H, Feskens, EJM, Hollman, PCH & Katan, MB (1995) Flavonoid intake and long-term risk of coronary heart disease and cancer in the seven countries study. Archives of Internal Medicine 155, 381–386.
Hillbom, M, Muuronen, A, Lowbeer, C, Anggard, E, Bevibng, H & Kangasaho, M (1985) Platelet thromboxane formation and bleeding time is influenced by ethanol withdrawal but not by cigarette smoking. Thrombosis and Haemostasis 53, 419–422.
Hines, LM, Stampfer, MJ, Ma, J, Gaziano, M, Ridker, PM, Hankinson, SE, Sacks, F, Rimm, EB & Hunter, DJ (2001) Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction. New England Journal of Medicine 344, 549–555.
Hohnloser, SH, Klingenheben, T, Zabel, M & Li, YG (1997) Heart rate variability used as an arrhythmia risk stratifier after myocardial infarction. Pacing and Clinical Electrophysiology 20, 2594–2601.
Hokanson, JE, Brunzell, JD, Jarvik, GP, Wijsman, EM & Austin, MA (1999) Linkage of low-density lipoprotein size to the lipoprotein lipase gene in heterozygous lipoprotein lipase deficiency. American Journal of Human Genetics 64, 608–618.
Hooper, L, Ness, AR & Smith, GD (2001) Meta-analysis of effect of high vs low vitamin E intake on cardiovascular mortality for observational and intervention studies. Lancet 357. 1705.
Howes, LG, Krum, H & Phillips, PA (1990) Effects of regular alcohol consumption on 24 hour ambulatory blood pressure recordings. Clinical and Experimental Pharmacology and Physiology 17, 247–250.
Hulley, SB & Gordon, S (1981) Alcohol and high-density lipoprotein cholesterol. Causal inference from diverse study designs. Circulation 64, Suppl. III, 57–63.
Ida, Y, Tsujimaru, S, Nakamaura, K, Shirao, I, Mukasa, H, Egami, H & Nakazawa, Y (1992) Effects of acute and repeated alcohol ingestion on hypothalamic-pituitary-gonadal and hypothalamic-pituitary-adrenal functioning in normal males. Drug and Alcohol Dependence 31, 57–64.
Kahn, HS & Williamson, DF (1994) Abdominal obesity and mortality risk among men in nineteenth-century North America. International Journal of Obesity 18, 686–691.
Kakko, S, Tamminen, M, Pälvänsalo, M, Kauma, H, Rantala, AO, Lilja, M, Reunanen, A, Kemäniemi, YA & Savolainen, MJ (2000) Cholesteryl ester transfer protein gene polymorphisms are associated with carotid atherosclerosis in men. European Journal of Clinical Investigation 30, 18–25.
Kauhanen, J, Kaplan, GA, Goldberg, DE, Salonen, R & Salonen, JT (1999) Pattern of alcohol drinking and progression of atherosclerosis. Arteriosclerosis, Thrombosis and Vascular Biology 19, 3001–3006.
Khaw, K-T, Wareham, N, Luben, R, Bingham, S, Oakes, S & Welch, A (2001) Glycated|haemoglobin, diabetes, and mortality in men in Norfolk cohort of European Prospective Investigation of Cancer and Nutrition (EPIC-Norfolk). British Medical Journal 322, 1–6.
Kiechl, S, Willeit, J, Poewe, W, Egger, G, Oberhollenzer, F, Muggeo, M & Bonora, E (1996) Insulin sensitivity and regular alcohol consumption: large, prospective, cross sectional population study (Bruneck study). British Medical Journal 313, 1040–1044.
Kiechl, S, Willeit, J, Rungger, G, Egger, G, Oberhollenzer, F & Bonora, E (1998) Alcohol consumption and atherosclerosis: what is the relation. Prospective results from the Bruneck Study. Stroke 29, 900–907.
Kim, KM, Chun, SB, Koo, MS, Choi, WJ, Kim, TW, Kwon, YG, Chung, HT, Billiar, TR & Kim, YM (2001) Differential regulation of NO availability from macrophages and endothelial cells by the garlic component S-allyl cysteine. Free Radical Biology and Medicine 30, 747–756.
Klurfeld, DM & Kritchevsky, D (1981) Different effects of alcoholic beverages on experimental atherosclerosis in rabbits. Experimental and Molecular Pathology 34, 62–71.
Koskinen, P, Virolainen, J & Kupari, M (1994) Acute alcohol intake decreases short-term heart rate variability in healthy subjects. Clinical Science 87, 225–230.
Langer, RD, Criqui, MH & Reed, DM (1992) Lipoproteins and blood pressure as biological pathways for effect of moderate alcohol consumption on coronary heart disease. Circulation 85, 910–915.
LaPorte, RE, Cresanta, JL & Kuller, LH (1980) The relationship of alcohol consumption to atherosclerotic heart disease. Preventive Medicine 9, 22–40.
Laug, WE (1983) Ethyl alcohol enhances plasminogen activator secretion by endothelial cells. Journal of the American Medical Association 250, 772–776.
Lazarus, R, Sparrow, D & Weiss, ST (1997) Alcohol intake and insulin levels. The Normative Ageing Study. American Journal of Epidemiology 145, 909–916.
Lee, AJ, Flanagan, PA, Rumley, A, Fowkes, FGR & Lowe, GDO (1995) Relationship between alcohol intake and tissue plaminogen activator antigen and other haemostatichemostatic factors in the general population. Fibrinolysis 8, 49–54.
Leo, R, Pratico, D, Iuliano, L, Pulcinelli, FM, Ghiselli, A, Pignatelli, P, Colavita, AR, FitzGerald, GA & Violi, F (1997) Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and then reoxygenated. Circulation 95, 885–891.
Lieber, CS (1991) Alcohol, liver, and nutrition. Journal of the American College of Nutrition 10, 602–632.
McConnell, MV, Vavouranakis, I, Wu, LL, Vaughan, DE & Ridker, PM (1997) Effects of a single, daily alcoholic beverage on lipid and hemostatic markers of cardiovascular risk. American Journal of Cardiology 80, 1226–1228.
McElduff, PM & Dobson, AJ (1997) How much alcohol and how often? Population based case–control study of alcohol consumption and risk of a major coronary event. British Medical Journal 314, 1159–1164.
Maiorano, G, Bartolomucci, F, Contursi, V, Saracino, E & Agostinacchio, E (1995) Effect of alcohol consumption versus abstinence on 24-h blood pressure profile in normotensive alcoholic patients. Journal of Hypertension 8, 80–81.
Mantle, D & Preedy, VR (1999) Free radicals as mediators of alcohol toxicity. Adverse Drug Reactions and Toxicological Reviews 18, 235–252.
Maresca, G, Di Blasio, A, Marchioli, R & Di Minno, G (1999) Measuring plasma fibrinogen to predict stroke and myocardial infarction. An update. Arteriosclerosis, Thrombosis, and Vascular Biology 19, 1368–1377.
Marmot, MG (1984) Alcohol and coronary heart disease. International Journal of Epidemiology 13, 160–167.
Mayer, O, Simon, J & Rosolová, H (2001) A population study of the influence of beer consumption on folate and homocysteine concentrations. European Journal of Clinical Nutrition 55, 605–609.
Meade, TW, Vickers, MV, Thompson, SG, Stirling, Y, Haines, AP & Miller, GJ (1985) Epidemiological characteristics of platelet aggregability. British Medical Journal 290, 428–432.
Mennen, LI, Balkau, B, Vol, S, Cacès, E & Eschwège, E (1999) Fibrinogen. A possible link between alcohol consumption and cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology 19, 887–892.
Mezey, E (1985) Metabolic effects of alcohol. Federation Proceedings 44, 134–138.
Mikhailidis, DP, Barradas, MA, Epemolu, O & Dandona, P (1987) Ethanol ingestion inhibits human whole blood platelet impedance aggregation. American Journal of Clinical Pathology 88, 342–345.
Miranda, CL, Stevens, JF, Ivanov, V, McCall, M, Frei, B, Deinzer, ML & Buhler, DR (2000) Antioxidant and prooxidant actions of prenylated and nonprenylated chalones and flavones in vitro. Journal of Agricultural and Food Chemistry 48, 3876–3884.
Moro, MÁ, Darley-Usmar, VM, Goodwin, DA, Read, NG, Zamora-Pino, R, Feelisch, M, Radomski, MW & Moncade, S (1994) Paradoxical fate and biological actions of peroxynitrite on human platelets. Proceedings of the National Academy of Sciences of the USA 91, 6702–6706.
Nakamura, T, Tokunaga, K, Shimomura, I, Nishida, M, Yoshida, S, Kotani, K, Islam, AH, Keno, Y, Kobatake, T & Nagai, Y (1994) Contribution of visceral fat accumulation to the development of coronary artery disease in non-obese men. Atherosclerosis 107, 239–246.
Nanji, AA (1985) Alcohol and ischemic heart disease: wine, beer or both? International Journal of Cardiology 8, 487–489.
Nappo, F, De Rosa, N, Marfella, R, De Lucia, D, Ingrosso, D, Perna, AF, Farzati, B & Giugliano, D (1999) Impairment of endothelial functions by acute hyperhomocysteinemia and reversal by antioxidant vitamins. Journal of the American Medical Association 281, 2113–2118.
Nishiwaki, M, Ishikawa, T, Ito, T, Shige, H, Tomiyasu, K, Nakajima, K, Kondo, K, Hashimoto, H, Saitoh, K & Manabe, M (1994) Effects of alcohol on lipoprotein lipase, hepatic|lipase, cholesteryl ester transfer|protein, and lecithin:cholesterol acyltransferase in high-density lipoprotein cholesterol elevation. Atherosclerosis 111, 99–109.
Numminen, H, Kobayashi, M, Uchiyama, S, Iwata, M, Ikeda, Y, Riutta, A, Syrjälä, M, Kekomaki, R & Hillbom, M (2000 a) Effects of alcohol and the evening meal on shear-induced platelet aggregation and urinary excretion of protanoids. Alcohol and Alcoholism 35, 594–600.
Numminen, H, Syrjälä, M, Benthin, G, Kaste, M & Hillbom, M (2000 b) The effect of acute ingestion of a large dose of alcohol on the hemostatic system and its circadian variation. Stroke 31, 1269–1273.
O'Callaghan, CJ, Phillips, PA, Krum, H & Howes, LG (1995) The effects of short-term alcohol intake on clinic and ambulatory blood pressure in normotensive social drinkers. American Journal of Hypertension 8, 572–577.
Pace-Asciak, CR, Hahn, S, Diamandis, EP, Soleas, G & Goldberg, DM (1995) The red wine phenolics trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis: Implications for protection against coronary heart disease. Clinica Chimica Acta 235, 207–219.
Pace-Asciak, CR, Rounova, O, Hahn, SE, Diamandis, EP & Goldberg, DM (1996) Wines and grape juices as modulators of platelet aggregation in healthy human subjects. Clinica Chimica Acta 246, 163–182.
Parthasarathy, S, Steinberg, D & Witztum, JL (1992) The role of oxidized low-density lipoproteins in the pathogenesis of atherosclerosis. Annual Review of Medicine 43, 219–225.
Paunio, M, Heinonen, O, Virtamo, J, Klag, MJ, Manninen, V, Albanes, D & Comstock, GW (1994) HDL cholesterol and mortality in Finnish Men with special reference to alcohol intake. Circulation 90, 2909–2918.
Pellegrini, N, Pareti, FI, Stabile, F, Brusamolino, A & Simonetti, P (1996) Effects of moderate consumption of red wine on platelet aggregation and haemostatic variables in healthy volunteers. European Journal of Clinical Nutrition 50, 209–213.
Pendurthi, UR, Williams, JT & Rao, LVM (1999) Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells. A possible mechanism for the cardiovascular benefits associated with moderate consumption of wine. Arteriosclerosis, Thrombosis and Vascular Biology 19, 419–426.
Perry, IJ, Wannamethee, SG, Walker, MK, Thomson, AG, Whincup, PH & Shaper, AG (1995) Protective study of risk factors for development of non-insulin dependent diabetes in middle aged British men. British Medical Journal 310, 560–564.
Pikaar, NA, Wedel, M, van der Beek, EJ, van Dokkum, Wim, Kempen, HJM, Kluft, C, Ockhuizen, T & Hermus, RJJ (1987) Effects of moderate alcohol consumption on platelet aggregation, fibrinolysis, and blood lipids. Metabolism 36, 538–543.
Prentice, AM (1995) Alcohol and obesity. International Journal of Obesity and Related Disorders 19, Suppl. 5, S44–S50.
Prinz, PN, Roehrs, TA, Vitaliano, PP, Linnoila, M & Weitzman, ED (1980) Effect of alcohol on sleep and night time growth hormone and cortisol concentrations. Journal of Clinical Endocrinology and Metabolism 51, 759–764.
Rakic, V, Puddey, IB, Burke, V, Dimmitt, SB & Beilin, LJ (1998) Influence of pattern of alcohol intake on blood pressure in regular drinkers: a controlled trial. Journal of Hypertension 16, 165–174.
Rand, ML, Packham, MA, Kinlough-Rathbone, RL & Fraser, MJ (1988) Effects of ethanol on pathways of platelet aggregation in vitro. Thrombosis and Haemostasis 59, 383–387.
Rao, MN, Lin, QH, Marmillot, P, Seeff, LB, Strader, DB & Lakshman, MR (2000) High-density lipoproteins from human alcoholics exhibit impaired reverse cholesterol transport function. Metabolism 49, 1406–1410.
Razay, G & Heaton, KW (1997) Moderate alcohol consumption has been shown previously to improve insulin sensitivity in men. British Medical Journal 314, 442–443.
Razzaghi, H, Aston, CE, Hamman, RF & Kamboh, MI (2000) Genetic screening of the lipoprotein lipase gene for mutations associated with high triglyceride/low HDL-cholesterol levels. Human Genetics 107, 257–267.
Renaud, S & De Lorgeril, M (1992) Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339, 1523–1526.
Renaud, SC, Beswick, AD, Fehily, AM, Sharp, DS & Elwood, PC (1992) Alcohol and platelet aggregation: the Caerphilly prospective heart disease study. American Journal of Clinical Nutrition 55, 1012–1017.
Ridker, PM, Vaughan, DE, Stampfer, MJ, Glynn, RJ & Hennekens, CH (1994) Association of moderate alcohol consumption and plasma concentration of endogenous tissue-type plasminogen activator. Journal of the American Medical Association 272, 929–933.
Rimm, EB, Giovannucci, EL, Willet, WC, Colditz, GA, Ascherio, A, Rosner, B & Stampfer, MJ (1991) Prospective study of alcohol consumption and risk of coronary disease in men. Lancet 338, 464–468.
Rimm, EB, Klatsky, A, Grobbee, D & Stampfer, MJ (1996) Review of moderate alcohol consumption and reduced risk of coronary heart disease: is the effect due to beer, wine, or spirits?. British Medical Journal 312, 731–736.
Rimm, EB, Willett, WC, Hu, FB, Sampson, L, Colditz, GA, Manson, JE, Hennekens, C & Stampfer, MJ (1998) Folate and vitamin B6 from diet and supplements in relation to risk of coronary heart disease among women. Journal of the American Medical Association 279, 359–364.
Rimm, EB, Williams, P, Fosher, K, Criqui, M & Stampfer, MJ (1999) Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. British Medical Journal 319, 1523–1528.
Rubin, R (1989) Ethanol interferes with collagen-induced platelet activation by inhibition of arachidonic acid mobilization. Archives of Biochemistry and Biophysics 270, 99–113.
Ruf, J-C, Berger, J-L & Renaud, S (1995) Platelet rebound effect of alcohol withdrawal and wine drinking in rats. Relation to tannins and lipid peroxidation. Arteriosclerosis, Thrombosis and Vascular Biology 15, 140–144.
Rumpler, WV, Clevidence, BA, Muesing, RA & Rhodes, DG (1999) Change in women's plasma lipid and lipoprotein concentrations due to moderate consumption of alcohol are affected by dietary fat level. Journal of Nutrition 129, 1713–1717.
Savolainen, MJ, Hannuksela, M, Seppänen, S, Kervinen, K & Kesäniemi, YA (1990) Increased high-density lipoprotein cholesterol concentration in alcoholics is related to low cholesteryl ester transfer protein activity. European Journal of Clinical Investigation 20, 593–599.
Savolainen, MJ & Kesäniemi, YA (1995) Effects of alcohol on lipoproteins in relation to coronary heart disease. Current Opinion in Lipidology 6, 243–250.
Schlotte, V, Sevanian, A, Hochstein, P & Weitmann, KU (1998) Effect of uric acid and chemical analogues on oxidation of human low density lipoprotein. Free Radicals in Biology and Medicine 25, 839–847.
Serafini, M, Maiani, G & Ferro-Luzzi, A (1998) Alcohol-free red wine enhances plasma antioxidant capacity in humans. Journal of Nutrition 128, 1003–1007.
Serebruany, VL, Lowry, DR, Fuzailov, SY, Levine, DJ, O'Connor, CM & Gurbel, PA (2000) Moderate alcohol consumption is associated with decreased platelet activity in patients presenting with acute myocardial infarction. Journal of Thrombosis and Thrombolysis 9, 229–234.
Shah, JH (1988) Alcohol decreases insulin sensitivity in healthy subjects. Alcohol and Alcoholism 23, 103–109.
Shelmet, JJ, Reichard, GA, Skutches, CL, Hoeldtke, RD, Owen, OE & Boden, G (1988) Ethanol causes acute inhibition of carbohydrate, fat, and protein oxidation and insulin resistance. Journal of Clinical Investigation 81, 1137–1145.
Sillanaukee, P, Koivula, T, Jokela, H, Myllyharju, H & Seppä, K (1993) Relationship of alcohol consumption to changes in HDL-subfractions. European Journal of Clinical Investigation 23, 486–491.
Sillanaukee, P, Koivula, T, Jokela, H, Pitkäjärvi, T & Seppä, K (2000) Alcohol consumption and its relation to lipid-based cardiovascular risk factors among middle-aged women: the role of HDL3 cholesterol. Atherosclerosis 152, 503–510.
Simon, J, Filipovsky, J, Rosolová, H, Topolcan, O & Karlicek, V (1988) Cross-sectional study of beer consumption and blood pressure in middle-aged men. Journal of Human Hypertension 2, 1–6.
Skutches, CL, Holroyde, CP, Myers, RN, Paul, P & Reichard, GA (1979) Plasma acetate turnover and oxidation. Journal of Clinical Investigation 64, 708–713.
Slattery, ML, McDonald, A, Bild, DE, Caan, BJ, Hilner, JE, Jacobs, DR & Liu, K (1992) Associations of body fat and its distribution with dietary intake, physical|activity, alcohol, and smoking in blacks and whites. American Journal of Clinical Nutrition 55, 943–949.
Stampfer, MJ, Sacks, FM, Simonettea, S, Willett, WC & Hennekens, CH (1991) A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. New England Journal of Medicine 325, 373–381.
Stokes, PE (1973) Adrenocortical activation in alcoholics during chronic drinking. Annals of the New York Academy of Sciences 215, 77–83.
Stubbs, CD & Rubin, R (1992) Effect of ethanol on platelet phopholipase A2. Lipids 27, 255–260.
Suter, PM, Häsler, E & Vetter, W (1997) Effects of alcohol on energy metabolism and body weight regulation: Is alcohol a risk factor for obesity? Nutrition Reviews 55, 157–171.
Taylor, KG, Carter, TJ, Valente, AJ, Wright, AD, Smith, JH & Matthews, KA (1981) Sex differences in the relationships between obesity, alcohol consumption and cigarette smoking and serum lipid and lipoprotein concentrations in a normal population. Atherosclerosis 38, 11–18.
Thögersen, AM, Jansson, J-H, Boman, K, Nilsson, TK, Weinehall, L, Huhtasaari, F & Hallmans, G (1998) High plasminogen activator inhibitor and tissue plasminogen activator levels in plasma precede a first acute myocardial infarction in both men and women. Evidence for the fibrinolytic system as an independent primary risk factor. Circulation 98, 2241–2247.
Thome, J, Foley, P, Gsell, W, Davids, E, Wodarz, N, Wiesbeck, A, Böning, J & Riederer, P (1997) Increased concentrations of manganese superoxide dismutase in serum of alcohol-dependent patients. Alcohol and Alcoholism 32, 65–69.
Tjønneland, A, Grønbæk, M, Stripp, C & Overvad, K (1999) Wine intake and diet in a random sample of 48763 Danish men and women. American Journal of Clinical Nutrition 69, 49–54.
Trevithick, CC, Vinson, JA, Caulfield, J, Rahman, F, Derksen, T, Bocksch, L, Hong, S, Srefan, A, Teufel, K, Wu, N, Hirst, M & Trevithick, JR (1999) Is ethanol an important antioxidant in alcoholic beverages associated with risk reduction of cataract and atherosclerosis? Redox Report 4, 89–93.
van de Wiel, A, van Golde, PM, Kraaijenhagen, RJ, von dem Borne, PAK, Bouma, BN & Hart, HC (2001) Acute inhibitory effect of alcohol on fibrinolysis. European Journal of Clinical Investigation 31, 164–170.
van der Gaag, MS, Ubbink, JB, Sillanaukee, P, Nikkari, S & Hendriks, HFJ (2000 a) Effect of consumption of red wine, spirits, and beer on serum homocysteine. Lancet 355. 1522.
van der Gaag, MS, van den Berg, R, van den Berg, H, Schaafsma, G & Hendriks, HFJ (2000) Moderate consumption of beer, red wine and spirits has counteracting effects on plasma antioxidants in middle-aged men. European Journal of Clinical Nutrition 54, 586–591.
van Golde, PHM, Sloots, LM, Vermeulen, WP, Wielders, JPM, Hart, HC, Bouma, BN & van de Wiel, A (1999) The role of alcohol in the anti low density lipoprotein oxidation activity of red wine. Atherosclerosis 147, 365–370.
van Leer, EM, Seidell, JC & Kromhout, D (1994) Differences in the association between alcohol consumption and blood pressure by age, gender, and smoking. Epidemiology 5, 576–582.
Van Tol, A, Groener, JE, Scheek, LM, Van Gent, T, Veenstra, J, Van de Pol, H, Hendriks, HF & Schaafsma, G (1995) Induction of net mass lipid transfer reactions in plasma by wine consumption with dinner. European Journal of Clinical Investigation 25, 390–395.
Veenstra, J, Kluft, C, Ockhuizen, TH, Pol, H, Wedel, M & Schaafsma, G (1990) Effects of moderate alcohol consumption on platelet function, tissue-type and plasminogen activator inhibitor. Thrombosis and Haemostasis 63, 345–348.
Veenstra, J, Ockhuizen, T, van de Pol, H, Wedel, M & Schaafsma, G (1990) Effects of a moderate dose of alcohol on blood lipids and lipoproteins postprandially and in the fasting state. Alcohol and Alcoholism 25, 371–377.
Venkov, CD, Myers, PR, Tanner, MA, Su, M & Vaughan, DE (1999) Ethanol increases endothelial nitric oxide production through modulation of nitric oxide synthase expression. Thrombosis and Haemostasis 81, 638–642.
Vermeulen, EGJ, Stehouwer, CDA, Twisk, JWR, van den Berg, M, de Jong, SC, Mackaay, AJC, van Campen, CMC, Visser, FC, Jakobs, CAJM, Bulterijs, EJ & Rauwerda, JA (2000) Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebo-controlled trial. Lancet 355, 517–522.
Vinson, JA, Jang, J, Yang, J, Dabbagh, Y, Liang, X, Serry, M, Proch, J & Cai, S (1999) Vitamins and especially flavonoids in common beverages are powerful in vitro antioxidants which enrich lower density lipoproteins and increase their oxidative resistance after ex vivo spiking in human plasma. Journal of Agricultural and Food Chemistry 47, 2502–2504.
Wannamethee, G & Shaper, AG (1992) Alcohol and sudden cardiac death. British Heart Journal 68, 443–448.
Wannamethee, SG & Shaper, AG (1999) Type of alcoholic drink and risk of major coronary heart disease events and all-cause mortality. American Journal of Public Health 89, 685–690.
Wannamethee, G, Whincup, PH, Shaper, AG, Walker, M & MacFarlane, PW (1995) Factors determining case fatality in myocardial infarction. British Heart Journal 74, 324–331.
Whitehead, TP, Robinson, D, Allaway, S, Syms, J & Hale, A (1995) Effect of red wine ingestion on the antioxidant capacity of serum. Clinical Chemistry 41, 32–35.
Witteman, JC, Willet, WC, Stampfer, MJ, Colditz, GA, Kok, FJ, Sacks, FM, Speizer, FE, Rosner, B & Hennekens, CH (1990) Relation of moderate alcohol consumption and risk of systemic hypertension in women. American Journal of Cardiology 65, 633–637.
Witztum, JL & Hörkkö, S (1997) The role of oxidized LDL in atherogenesis: Immunological response and anti-phospholipid antibodies. Annals of the New York Academy of Sciences 811, 88–96.
Woo, KS, Chook, P, Lolin, YI, Cheung, ASP, Chan, RN, Sun, YY, Sanderson, JE, Metreweli, C & Celermajer, DS (1997) Hyperhomocyst(e)inemia is a risk factor for arterial endothelial dysfunction in humans. Circulation 96, 2542–2544.
Xia, J, Allenbrand, B & Sun, GY (1998) Dietary supplementation of grape polyphenols and chronic ethanol administration on LDL oxidation and platelet function in rats. Life Science 63, 383–390.
Yamamoto, M, Egusa, G, Hara, H & Yamakido, M (1997) Association of intraabdominal fat and carotid atherosclerosis in non-obese middle-aged men with normal glucose tolerance. International Journal of Obesity and Related Disorders 21, 948–951.
Zhang, QH, Das, K, Siddiqui, S & Myers, AK (2000) Effects of acute, moderate ethanol consumption on human platelet aggregation in platelet-rich plasma and whole blood. Alcoholism, Clinical and Experimental Research 24, 528–534.