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Verbal fluency in HIV infection: A meta-analytic review

Published online by Cambridge University Press:  13 December 2006

JENNIFER E. IUDICELLO ,
STEVEN PAUL WOODS ,
THOMAS D. PARSONS ,
LISA M. MORAN ,
CATHERINE L. CAREY  and
IGOR GRANT
JENNIFER E. IUDICELLO
Affiliation:
Joint Doctoral Program in Clinical Psychology, San Diego State University and University of California, San Diego, San Diego, California Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, California
STEVEN PAUL WOODS
Affiliation:
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, California
THOMAS D. PARSONS
Affiliation:
Department of Neurology, University of North Carolina, Chapel Hill, School of Medicine, Chapel Hill, North Carolina Institute of Creative Technologies, University of Southern California, Marina Del Rey, California
LISA M. MORAN
Affiliation:
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, California
CATHERINE L. CAREY
Affiliation:
Department of Psychiatry, University of California, San Francisco, School of Medicine, San Francisco, California
IGOR GRANT
Affiliation:
Department of Psychiatry, HIV Neurobehavioral Research Center, University of California, San Diego, School of Medicine, La Jolla, California
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Abstract

Given the largely prefrontostriatal neuropathogenesis of HIV-associated neurobehavioral deficits, it is often presumed that HIV infection leads to greater impairment on letter versus category fluency. A meta-analysis of the HIV verbal fluency literature was conducted (k = 37, n = 7110) to assess this hypothesis and revealed generally small effect sizes for both letter and category fluency, which increased in magnitude with advancing HIV disease severity. Across all studies, the mean effect size of category fluency was slightly larger than that of letter fluency. However, the discrepancy between category and letter fluency dissipated in a more conservative analysis of only those studies that included both tests. Thus, HIV-associated impairments in letter and category fluency are of similar magnitude, suggesting that mild word generation deficits are evident in HIV, regardless of whether traditional letter or semantic cues are used to guide the word search and retrieval process (JINS, 2007, 13, 183–189.)

Keywords

HIVAIDS dementia complexNeuropsychologyNeuropsychological testsVerbal fluencyCognitive processes
Type
BRIEF COMMUNICATIONS
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 1 , January 2007 , pp. 183 - 189
Copyright
© 2007 The International Neuropsychological Society

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