Skip to main content Accessibility help
×
Home

Verbal and Visuospatial Span in Logopenic Progressive Aphasia and Alzheimer's Disease

  • David G. Foxe (a1), Muireann Irish (a1) (a2) (a3), John R. Hodges (a1) (a2) (a3) and Olivier Piguet (a1) (a2) (a3)

Abstract

Logopenic progressive aphasia (LPA) is a form of primary progressive aphasia (PPA) characterized by hesitant speech with marked impairment in naming and repetition. LPA is associated with brain atrophy in the left temporal and inferior parietal cortices and is predominantly associated with Alzheimer's disease (AD) pathology. In contrast to LPA, “typical” AD is commonly associated with episodic memory disturbance and bilateral medial temporal lobe atrophy. Recent evidence suggests verbal short-term memory is more impaired than visuospatial short-term memory in LPA. This study investigated verbal and visuospatial short-term memory in 12 LPA and 12 AD patients matched for disease severity, and in 12 age- and education-matched healthy controls. Overall, both patient groups showed significantly reduced verbal and visuospatial spans compared with controls. In addition, LPA patients performed significantly worse than AD patients on both forward and backward conditions of the Digit Span task. In contrast, no difference was present between patient groups on either version of the Spatial Span task. Importantly, LPA patients showed better visuospatial than verbal span whereas AD patients and controls did not differ across modality. This study demonstrates the specificity of the short-term memory disturbance in LPA, which arises from a breakdown of the phonological system. (JINS, 2012, 19, 1–7)

Copyright

Corresponding author

Correspondence and reprint requests to: Olivier Piguet, Neuroscience Research Australia, Barker Street, Randwick NSW 2031, Australia. E-mail: o.piguet@neura.edu.au

References

Hide All
Baddeley, A. (2003). Working memory: Looking back and looking forward. Nature Reviews Neuroscience, 4(10), 829839.
Baddeley, A., Emslie, H., Nimmo-Smith, I. (1994). Doors and people. Bury St Edmunds: Thames Valley Test Company.
Benton, A.L., Hamsher, deS., Sivian, A.B. (1994). Multilingual aphasia examination (3rd ed.). Iowa City: AJA Associates, Inc.
Bor, D., Duncan, J., Lee, A.C., Parr, A., Owen, A.M. (2006). Frontal lobe involvement in spatial span: Converging studies of normal and impaired function. Neuropsychologia, 44(2), 229237.
Braak, H., Braak, E. (1995). Staging of Alzheimer's disease-related neurofibrillary changes. Neurobiology of Aging, 16(3), 271278.
Carlesimo, G.A., Fadda, L., Lorusso, S., Caltagirone, C. (1994). Verbal and spatial memory spans in Alzheimer's and multi-infarct dementia. Acta Neurologica Scandinavica, 89(2), 132138.
Carlesimo, G.A., Mauri, M., Graceffa, A.M., Fadda, L., Loasses, A., Lorusso, S., Caltagirone, C. (1998). Memory performances in young, elderly, and very old healthy individuals versus patients with Alzheimer's disease: Evidence for discontinuity between normal and pathological aging. Journal of Clinical and Experimental Neuropsychology, 20(1), 1429.
Collette, F., Van der Linden, M., Bechet, S., Salmon, E. (1999). Phonological loop and central executive functioning in Alzheimer's disease. Neuropsychologia, 37(8), 905918.
D'Esposito, M., Aguirre, G.K., Zarahn, E., Ballard, D., Shin, R.K., Lease, J. (1998). Functional MRI studies of spatial and nonspatial working memory. Brain Research Cognitive Brain Research, 7(1), 113.
Desikan, R.S., Cabral, H.J., Hess, C.P., Dillon, W.P., Glastonbury, C.M., Weiner, M.W., … Alzheimer's Disease Neuroimaging Initiative (2009). Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer's disease s disease. Brain, 132(Pt 8), 20482057.
Dubois, B., Feldman, H.H., Jacova, C., Dekosky, S.T., Barberger-Gateau, P., Cummings, J., Scheltens, P. (2007). Research criteria for the diagnosis of Alzheimer's disease: Revising the NINCDS-ADRDA criteria. Lancet Neurology, 6(8), 734746.
Gelinas, I., Gauthier, L., McIntyre, M., Gauthier, S. (1999). Development of a functional measure for persons with Alzheimer's disease: The disability assessment for dementia. American Journal of Occupational Therapy, 53(5), 471481.
Goll, J.C., Kim, L.G., Hailstone, J.C., Lehmann, M., Buckley, A., Crutch, S.J., Warren, J.D. (2011). Auditory object cognition in dementia. Neuropsychologia, 49(9), 27552765.
Gorno-Tempini, M.L., Brambati, S.M., Ginex, V., Ogar, J., Dronkers, N.F., Marcone, A., Miller, B.L. (2008). The logopenic/phonological variant of primary progressive aphasia. Neurology, 71(16), 12271234.
Gorno-Tempini, M.L., Dronkers, N.F., Rankin, K.P., Ogar, J.M., Phengrasamy, L., Rosen, H.J., Miller, B.L. (2004). Cognition and anatomy in three variants of primary progressive aphasia. Annals of Neurology, 55(3), 335346.
Gorno-Tempini, M.L., Hillis, A.E., Weintraub, S., Kertesz, A., Mendez, M., Cappa, S.F., Grossman, M. (2011). Classification of primary progressive aphasia and its variants. Neurology, 76(11), 10061014.
Hartley, A.A., Speer, N.K. (2000). Locating and fractionating working memory using functional neuroimaging: Storage, maintenance, and executive functions. Microscopy Research and Technique, 51(1), 4553.
Henson, R.N., Burgess, N., Frith, C.D. (2000). Recoding, storage, rehearsal and grouping in verbal short-term memory: An fMRI study. Neuropsychologia, 38(4), 426440.
Hodges, J.R., Martinos, M., Woollams, A.M., Patterson, K., Adlam, A.L. (2008). Repeat and Point: Differentiating semantic dementia from progressive non-fluent aphasia. Cortex, 44(9), 12651270.
Hodges, J.R., Salmon, D.P., Butters, N. (1991). The nature of the naming deficit in Alzheimer's and Huntington's disease. Brain, 114(Pt 4), 15471558.
Hodges, J.R., Salmon, D.P., Butters, N. (1992). Semantic memory impairment in Alzheimer's disease: Failure of access or degraded knowledge? Neuropsychologia, 30(4), 301314.
Huntley, J.D., Howard, R.J. (2010). Working memory in early Alzheimer's disease: A neuropsychological review. International Journal of Geriatric Psychiatry, 25(2), 121132.
Kertesz, A., Davidson, W., McCabe, P., Takagi, K., Munoz, D. (2003). Primary progressive aphasia: Diagnosis, varieties, evolution. Journal of the International Neuropsychological Society, 9(5), 710719.
Klunk, W.E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D.P., Langstrom, B. (2004). Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound-B. Annals of Neurology, 55(3), 306319.
Laures-Gore, J., Marshall, R.S., Verner, E. (2011). Performance of individuals with left-hemisphere stroke and aphasia and individuals with right brain damage on forward and backward digit span tasks. Aphasiology, 25(1), 4356.
Leyton, C.E., Piguet, O., Savage, S., Burrell, J., Hodges, J.R. (2012). Naming and repetition in logopenic progressive aphasia. Journal of Alzheimer's Disease, [Epub ahead of print].
Leyton, C.E., Villemagne, V.L., Savage, S., Pike, K.E., Ballard, K.J., Piguet, O., Hodges, J.R. (2011). Subtypes of progressive aphasia: Application of the International Consensus Criteria and validation using beta-amyloid imaging. Brain, 134(Pt 10), 30303043.
Martin, N., Ayala, J. (2004). Measurements of auditory-verbal STM span in aphasia: Effects of item, task, and lexical impairment. Brain and Language, 89(3), 464483.
McKhann, G.M., Knopman, D.S., Chertkow, H., Hyman, B.T., Jack, C.R. Jr., Kawas, C.H., Phelps, C.H. (2011). The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's and Dementia, 7(3), 263269.
Mesulam, M., Wicklund, A., Johnson, N., Rogalski, E., Leger, G.C., Rademaker, A., Bigio, E.H. (2008). Alzheimer and frontotemporal pathology in subsets of primary progressive aphasia. Annals of Neurology, 63(6), 709719.
Meyers, J.E., Meyers, K.R. (1995). Rey Complex Figure Test and Recognition Trial. Odessa, FL: Psychological Assessment Resources, Inc.
Migliaccio, R., Agosta, F., Rascovsky, K., Karydas, A., Bonasera, S., Rabinovici, G.D., Gorno-Tempini, M.L. (2009). Clinical syndromes associated with posterior atrophy: Early age at onset AD spectrum. Neurology, 73(19), 15711578.
Mioshi, E., Dawson, K., Mitchell, J., Arnold, R., Hodges, J.R. (2006). The Addenbrooke's Cognitive Examination Revised (ACE-R): A brief cognitive test battery for dementia screening. International Journal of Geriatric Psychiatry, 21(11), 10781085.
Owen, A.M. (2000). The role of the lateral frontal cortex in mnemonic processing: The contribution of functional neuroimaging. Experimental Brain Research, 133(1), 3343.
Owen, A.M., Herrod, N.J., Menon, D.K., Clark, J.C., Downey, S.P., Carpenter, T.A., Pickard, J.D. (1999). Redefining the functional organization of working memory processes within human lateral prefrontal cortex. The European Journal of Neuroscience, 11(2), 567574.
Parmentier, F.B., Andres, P., Elford, G., Jones, D.M. (2006). Organization of visuo-spatial serial memory: Interaction of temporal order with spatial and temporal grouping. Psychological Research, 70(3), 200217.
Peters, F., Majerus, S., Olivier, L., van der Linden, M., Salmon, E., Collette, F. (2007). A multicomponent exploration of verbal short-term storage deficits in normal aging and Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology, 29(4), 405417.
Rabinovici, G.D., Jagust, W.J., Furst, A.J., Ogar, J.M., Racine, C.A., Mormino, E.C., Gorno-Tempini, M.L. (2008). Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia. Annals of Neurology, 64(4), 388401.
Ravizza, S.M., Hazeltine, E., Ruiz, S., Zhu, D.C. (2011). Left TPJ activity in verbal working memory: Implications for storage- and sensory-specific models of short term memory. Neuroimage, 55(4), 18361846.
Reitan, R.M. (1955). The relation of the trail making test to organic brain damage. Journal of Consulting Psychology, 19(5), 393394.
Rohrer, J.D., Ridgway, G.R., Crutch, S.J., Hailstone, J., Goll, J.C., Clarkson, M.J., Warren, J.D. (2010). Progressive logopenic/phonological aphasia: Erosion of the language network. Neuroimage, 49(1), 984993.
Rohrer, J.D., Rossor, M.N., Warren, J.D. (2012). Alzheimer's pathology in primary progressive aphasia. Neurobiology of Aging, 33, 744752.
Rosenthal, R. (1991). Meta-analytic procedures for social research (revised edition). Newbury Park, CA: Sage.
Salmon, E., Sadzot, B., Maquet, P., Degueldre, C., Lemaire, C., Rigo, P., Franck, G. (1994). Differential diagnosis of Alzheimer's disease with PET. Journal of Nuclear Medicine, 35(3), 391398.
Schum, R.L., Sivan, A.B. (1997). Verbal abilities in healthy elderly adults. Applied Neuropsychology, 4(2), 130134.
Smith, E.E., Jonides, J. (1997). Working memory: A view from neuroimaging. Cognitive Psychology, 33(1), 542.
Smith, E.E., Jonides, J., Koeppe, R.A. (1996). Dissociating verbal and spatial working memory using PET. Cerebral Cortex, 6(1), 1120.
Smith, E.E., Jonides, J., Marshuetz, C., Koeppe, R.A. (1998). Components of verbal working memory: Evidence from neuroimaging. Proceedings of the National Academy of Sciences of the United States of America, 95(3), 876882.
Toepper, M., Beblo, T., Thomas, C., Driessen, M. (2008). Early detection of Alzheimer's disease: A new working memory paradigm. International Journal of Geriatric Psychiatry, 23(3), 272278.
van Asselen, M., Kessels, R.P., Neggers, S.F., Kappelle, L.J., Frijns, C.J., Postma, A. (2006). Brain areas involved in spatial working memory. Neuropsychologia, 44(7), 11851194.
Weintraub, S., Wicklund, A.H., Salmon, D.P. (2012). The neuropsychological profile of Alzheimer disease. Cold Spring Harbour Perspectives in Medicine, 2(4), a006171. doi:10.1101/cshperspect.a006171
Weschler, D. (1997). Weschler Memory Scale – Third edition: Administration and scoring manual. San Antonio: TX: Psychological Corporation.
Wilde, N., Strauss, E. (2002). Functional equivalence of WAIS-III/WMS-III digit and spatial span under forward and backward recall conditions. The Clinical Neuropsychologist, 16(3), 322330.

Keywords

Verbal and Visuospatial Span in Logopenic Progressive Aphasia and Alzheimer's Disease

  • David G. Foxe (a1), Muireann Irish (a1) (a2) (a3), John R. Hodges (a1) (a2) (a3) and Olivier Piguet (a1) (a2) (a3)

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed