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Strategic Manipulations for Associative Memory and the Role of Verbal Processing Abilities in Schizophrenia

  • Aaron Bonner-Jackson (a1) (a2) and Deanna M. Barch (a3)

Abstract

Individuals with schizophrenia demonstrate episodic memory (EM) deficits and abnormal EM-related brain activity. Experimental encoding manipulations significantly benefit memory performance in schizophrenia, suggesting that a strategic processing deficit may contribute to memory impairment. However, few studies have investigated the combined effects of encoding and retrieval strategies on EM in schizophrenia. The current study examined the impact of encoding and retrieval strategies on associative memory and brain activity in schizophrenia. We also assessed the role of verbal processing ability in response to strategic memory interventions in schizophrenia. Behavioral and functional neuroimaging data were collected from 23 participants with schizophrenia and 24 comparison subjects while performing associative memory encoding and recall tasks. Behaviorally, both schizophrenia participants and controls benefited from memory strategies and showed significant associations between verbal processing ability and recall. Additionally, among schizophrenia participants, encoding strategy use was associated with enhanced brain activity in multiple brain areas. Schizophrenia participants also demonstrated significant associations between verbal processing ability and encoding-related brain activity in prefrontal cortex. Findings suggest that memory performance and brain activity in schizophrenia can be enhanced via strategic manipulations, and individual differences in cognitive abilities in schizophrenia can affect behavioral and neurobiological responses to strategic memory interventions. (JINS, 2011, 17, 796–806)

Copyright

Corresponding author

Correspondence and reprint requests to: Aaron Bonner-Jackson, Rhode Island Hospital, Physicians Office Building, 593 Eddy Street, Providence, Rhode Island 02903. E-mail: aaron_bonner-jackson@brown.edu

References

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Achim, A.M., Bertrand, M.C., Sutton, H., Montoya, A., Czechowska, Y., Malla, A.K., Lepage, M. (2007). Selective abnormal modulation of hippocampal activity during memory formation in first-episode psychosis. Archives of General Psychiatry, 64, 9991014.
Andreasen, N.C. (1983a). The Scale for the Assessment of Negative Symptoms (SANS). Iowa City: University of Iowa.
Andreasen, N.C. (1983b). The Scale for the Assessment of Positive Symptoms (SAPS). Iowa City: University of Iowa.
Barch, D.M., Csernansky, J., Conturo, T., Snyder, A.Z., Ollinger, J. (2002). Working and long-term memory deficits in schizophrenia. Is there a common underlying prefrontal mechanism? Journal of Abnormal Psychology, 111, 478494.
Barch, D.M., Mathews, J.R., Buckner, R.L., Maccotta, L., Csernansky, J.G., Snyder, A.Z. (2003). Hemodynamic responses in visual, motor, and somatosensory cortices in schizophrenia. Neuroimage, 20, 18841893.
Bonner-Jackson, A., Haut, K.M., Csernansky, J.G., Barch, D.M. (2005). The influence of encoding strategy on episodic memory and cortical activity in schizophrenia. Biological Psychiatry, 58, 4755.
Brebion, G., Amador, X., Smith, M.J., Gorman, J.M. (1997). Mechanisms underlying memory impairment in schizophrenia. Psychological Medicine, 27, 383393.
Brebion, G., David, A., Jones, H., Pilowsky, L. (2004). Semantic organization and verbal memory efficiency in patients with schizophrenia. Neuropsychology, 18(2), 378383.
Chan, A.S., Kwok, I.C., Chiu, H., Lam, L., Pang, A., Chow, L. (2000). Memory and organizational strategies in chronic and acute schizophrenic patients. Schizophrenia Research, 41, 431445.
Cirillo, M.A., Seidman, L.J. (2003). Verbal declarative memory dysfunction in schizophrenia: From clinical assessment to genetics and brain mechanisms. Neuropsychology Review, 13, 4377.
Culver, L.C., Kunen, S., Zinkgraf, S.A. (1986). Patterns of recall in schizophrenics and normal subjects. Journal of Nervous and Mental Disease, 174, 620623.
Danion, J.M., Rizzo, L., Bruant, A. (1999). Functional mechanisms underlying impaired recognition memory and conscious awareness in patients with schizophrenia. Archives of General Psychiatry, 56(7), 639644.
Gold, J.M., Randolph, C., Carpenter, C.J., Goldberg, T.E., Weinberger, D.R. (1992). Forms of memory failure in schizophrenia. Journal of Abnormal Psychology, 101(3), 487494.
Hazlett, E.A., Buchsbaum, M.S., Jeu, L.A., Nenadic, I., Fleischman, M.B., Shihabuddin, L., Harvey, P.D. (2000). Hypofrontality in unmedicated schizophrenia patients studied with PET during performance of a serial verbal learning task. Schizophrenia Research, 43, 3346.
Hofer, A., Weiss, E.M., Golaszewski, S.M., Siedentopf, C.M., Brinkhoff, C., Kremser, C., Fleischhacker, W.W. (2003). Neural correlates of episodic encoding and recognition of words in unmedicated patients during an acute episode of schizophrenia: A functional MRI study. American Journal of Psychiatry, 160, 18021808.
Howard, D., Patterson, K. (1992). Pyramids and palm trees: A test of semantic access from pictures and words. Bury St. Edmunds: Thames Valley Test Company.
Huron, C., Danion, J.M., Giacomoni, F., Grange, D., Robert, P., Rizzo, L. (1995). Impairment of recognition memory with, but not without, conscious recollection in schizophrenia. American Journal of Psychiatry, 152, 17371742.
Hutton, S.B., Puri, B.K., Duncan, L.J., Robbins, T.W., Barnes, T.R., Joyce, E.M. (1998). Executive function in first-epsiode schizophrenia. Psychological Medicine, 28(2), 463473.
Iddon, J.L., McKenna, P.J., Sahakian, B.J., Robbins, T.W. (1998). Impaired generation and use of strategy in schizophrenia: Evidence from visuospatial and verbal tasks. Psychological Medicine, 28, 10491062.
Koh, S.D. (1978). Remembering of verbal material by schizophrenic young adults. In S. Schwartz (Ed.), Language and cognition in schizophrenia (pp. 5599). Hillsdale, NJ: Erlbaum.
Koh, S.D., Peterson, R.A. (1978). Encoding orientation and the remembering of schizophrenic young adults. Journal of Abnormal Psychology, 87(3), 303313.
Kubicki, M., McCarley, R.W., Nestor, P.G., Huh, T., Kikinis, R., Shenton, M.E., Wible, C.G. (2003). An fMRI study of semantic processing in men with schizophrenia. Neuroimage, 20, 19231933.
McClain, L. (1983). Encoding and retrieval in schizophrenics’ free recall. Journal of Nervous and Mental Disease, 171, 471479.
Naghavi, H.R., Nyberg, L. (2005). Common fronto-parietal activity in attention, memory, and consciousness: Shared demands on integration? Consciousness and Cognition, 14, 390425.
Naveh-Benjamin, M., Craik, F.I.M., Ben-Shaul, L. (2002). Age-related differences in cued recall: Effects of support at encoding and retrieval. Aging, Neuropsychology and Cognition, 9, 276287.
Nohara, S., Suzuki, M., Kurachi, M., Yamashita, I., Matsui, M., Seto, H., Saitoh, O. (2000). Neural correlates of memory organization deficits in schizophrenia. Schizophrenia Research, 42, 209220.
Paul, B.M., Elvevag, B., Bokat, C.E., Weinberger, D.R., Goldberg, T.E. (2005). Levels of processing effects on recognition memory in patients with schizophrenia. Schizophrenia Research, 74, 101110.
Ragland, J.D., Gur, R.C., Raz, J., Schroeder, L., Kohler, C.G., Smith, R.J., Gur, R.E. (2001). Effect of schizophrenia on frontotemporal activity during word encoding and recognition: A PET cerebral blood flow study. American Journal of Psychiatry, 158, 11141125.
Ragland, J.D., Gur, R.C., Valdez, J., Loughead, J., Elliott, M., Kohler, C., Gur, R.E. (2005). Levels-of-processing effect on frontotemporal function in schizophrenia during word encoding and recognition. American Journal of Psychiatry, 162, 18401848.
Ragland, J.D., McCarthy, E., Bilker, W.B., Brensinger, C.M., Valdez, J., Kohler, C., Gur, R.C. (2006). Levels-of-processing effect on internal source monitoring in schizophrenia. Psychological Medicine, 36, 641648.
Ragland, J.D., Moelter, S.T., McGrath, C., Hill, S.K., Gur, R.E., Bilker, W.B., Gur, R.C. (2003). Levels-of-processing effect on word recognition in schizophrenia. Biological Psychiatry, 54, 11541161.
Russell, P.N., Bannatyne, P.A., Smith, J.F. (1975). Associative strength as a mode of organization in recall and recognition: A comparison of schizophrenics and normals. Journal of Abnormal Psychology, 84, 122128.
Russell, P.N., Beekhuis, M.E. (1976). Organization in memory: A comparison of psychotics and normals. Journal of Abnormal Psychology, 85, 527534.
Saykin, A.J., Shtasel, D.L., Gur, R.E., Kester, D.B., Mozley, L.H., Stafiniak, P., Gur, R.C. (1994). Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Archives of General Psychiatry, 51, 124131.
Sengel, R.A., Lovallo, W.R. (1983). Effects of cueing on immediate and recent memory in schizophrenics. Journal of Nervous and Mental Disease, 171(7), 426430.
Smith, E.E., Jonides, J. (1999). Storage and executive processes in the frontal lobes. Science, 283, 16571661.
Talairach, J., Tournoux, P. (1988). Co-planar stereotaxic atlas of the human brain. New York: Thieme.
Thompson-Schill, S.L., D'Esposito, M., Aguire, G.K., Farah, M.J. (1997). Role of left inferior prefrontal cortex in retrieval of semantic knowledge: A re-evaluation. Proceedings of the National Academy of Sciences of the United States of America, 94, 1479214797.
Tompkins, L.M., Goldman, R.S., Axelrod, B.N. (1995). Modifiability of neuropsychological dysfunction in schizophrenia. Biological Psychiatry, 38, 105111.
Traupmann, K.L. (1980). Encoding processes and memory for categorically related words by schizophrenic patients. Journal of Abnormal Psychology, 89, 704716.
Wechsler, D. (1997). Wechsler adult intelligence scale – third edition. San Antonio: The Psychological Corporation.
Yonelinas, A.P., Jacoby, L.L. (1994). Dissociations of processes in recognition memory: Effects of interference and of response speed. Canadian Journal of Experimental Psychology, 48, 516534.

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