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Semantic Clustering of Category Fluency in Schizophrenia Examined with Singular Value Decomposition

  • Kyongje Sung (a1), Barry Gordon (a1) (a2), Tracy D. Vannorsdall (a3), Kerry Ledoux (a1), Erin J. Pickett (a1), Godfrey D. Pearlson (a4) (a5) and David J. Schretlen (a3) (a6)...

Abstract

Decreased productivity on verbal fluency tasks by persons with schizophrenia has been attributed to semantic system abnormalities. Semantic structure is often assessed using multidimensional scaling (MDS) to detect normal and aberrant semantic clustering. However, MDS has limitations that may be particularly problematic for such assessments. Here, we introduce a different clustering technique, singular value decomposition (SVD), to elucidate abnormalities of the semantic system in schizophrenia. We compared 102 treated outpatients with schizophrenia to 109 healthy adults on two category-cued word fluency tasks. Patients with schizophrenia showed semantic clustering patterns that differ markedly from those of healthy adults. However, SVD revealed more detailed and critical semantic system abnormalities than previously appreciated using MDS. Patients with schizophrenia showed less coherent semantic clustering of both low- and high-frequency category exemplars than healthy adults. These results suggest the intriguing possibility that impaired automatic activation of semantic information is a key deficit in schizophrenia. (JINS, 2012, 18, 565–575)

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Corresponding author

Correspondence and reprint requests to: David J. Schretlen, Johns Hopkins Hospital, 600 N. Wolfe Street, Meyer 218, Baltimore, MD 21287-7218. E-mail: dschret@jhmi.edu

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Allen, H.A., Frith, C.D. (1983). Selective retrieval and free emission of category exemplars in schizophrenia. British Journal of Psychology, 74, 481490.
Allen, H.A., Liddle, P.F., Frith, C.D. (1993). Negative features, retrieval-processes and verbal fluency in schizophrenia. British Journal of Psychiatry, 163, 769775.
Aloia, M.S., Gourovitch, M.L., Missar, D., Pickar, D., Weinberger, D.R., Goldberg, T.E. (1998). Cognitive substrates of thought disorder, II: Specifying a candidate cognitive mechanism. American Journal of Psychiatry, 155(12), 16771684.
Aloia, M.S., Gourovitch, M.L., Weinberger, D.R., Goldberg, T.E. (1996). An investigation of semantic space in patients with schizophrenia. Journal of the International Neuropsychological Society, 2(4), 267273.
Alter, O., Brown, P.O., Botstein, D. (2000). Singular value decomposition for genome-wide expression data processing and modeling. Proceedings of the National Academy of Sciences of the United States of America, 97(18), 1010110106.
American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders: DSM-IV (4th ed.). Washington, DC: American Psychiatric Association.
Andreasen, N.C., Olsen, S. (1982). Negative v positive schizophrenia. Definition and validation. Archives of General Psychiatry, 39(7), 789794.
Bokat, C.E., Goldberg, T.E. (2003). Letter and category fluency in schizophrenic patients: A meta-analysis. Schizophrenia Research, 64(1), 7378.
Bozikas, V.P., Kosmidis, M.H., Karavatos, A. (2005). Disproportionate impairment in semantic verbal fluency in schizophrenia: Differential deficit in clustering. Schizophrenia Research, 74(1), 5159.
Chan, A.S., Butters, N., Paulsen, J.S., Salmon, D.P., Swenson, M.R., Maloney, L.T. (1993). An assessment of the semantic network in patients with Alzheimers-disease. Journal of Cognitive Neuroscience, 5(2), 254261.
Chan, A.S., Butters, N., Salmon, D.P., Mcguire, K.A. (1993). Dimensionality and Clustering in the Semantic Network of Patients with Alzheimers-Disease. Psychology and Aging, 8(3), 411419.
Chan, A.S., Ho, Y.C. (2003). Things aren't as bad as they seem: A comment on Storms et al. (2003). Neuropsychology, 17(2), 302305.
Folstein, M.F., Folstein, S.E., McHugh, P.R. (1975). “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12(3), 189198.
Giovannetti, T., Goldstein, R.Z., Schullery, M., Barr, W.B., Bilder, R.M. (2003). Category fluency in first-episode schizophrenia. Journal of the International Neuropsychological Society, 9(3), 384393.
Gourovitch, M.L., Goldberg, T.E., Weinberger, D.R. (1996). Verbal fluency deficits in patients with schizophrenia: Semantic fluency is differentially impaired as compared with phonologic fluency. Neuropsychology, 10(4), 573577.
Hu, X., Cai, Z., Franceschetti, D., Penumatsa, P., Graesser, A. C., Louwerse, M.M., … Tutoring Research Group. (2003). LSA: First dimension and dimensional weighting. Paper presented at the Proceedings of the 25th Annual Conference of the Cognitive Science Society, Boston.
Joyce, E.M., Collinson, S.L., Crichton, P. (1996). Verbal fluency in schizophrenia: Relationship with executive function, semantic memory and clinical alogia. Psychological Medicine, 26(1), 3949.
Landauer, T.K. (1999). Latent semantic analysis: A theory of the psychology of language and mind. Discourse Processes, 27(3), 303310.
Landauer, T.K. (2007). LSA as a theory of meaning. In T. Landauer, D.S. McNamara, S. Dennis & W. Kintsch (Eds.), Handbook of latent semantic analysis (pp. 334). Mahwah, NJ: LEA.
Landauer, T.K., Dumais, S.T. (1997). A solution to Plato's problem: The latent semantic analysis theory of acquisition, induction, and representation of knowledge. Psychological Review, 104(2), 211240.
Landauer, T.K., McNamara, D.S., Dennis, S., Kintsch, W. (2007). Handbook of latent semantic analysis. Mahwah, NJ: LEA.
Larsen, R.M. (2004). PROPACK for Matlab 1.1. Retrieved from http://soi.stanford.edu/~rmunk/PROPACK/index.html.
Laws, K.R., Al-Uzri, M., Mortimer, A.M. (2000). Lexical knowledge degradation in schizophrenia. Schizophrenia Research, 45(1–2), 123131.
Leeson, V.C., Laws, K.R., McKenna, P.J. (2006). Formal thought disorder is characterised by impaired lexical access. Schizophrenia Research, 88(1–3), 161168.
Meehl, P.E. (1970). Nuisance variables and the ex post facto design. In M. Radner & S. Winokur (Eds.), Minnesota studies in the philosophy of science. Minneapolis: University of Minnesota Press.
Moelter, S.T., Hill, S.K., Ragland, J.D., Lunardelli, A., Gur, R.C., Gur, R.E., Moberg, P.J. (2001). Controlled and automatic processing during animal word list generation in schizophrenia. Neuropsychology, 15(4), 502509.
Nurnberger, J.I. Jr., Blehar, M.C., Kaufmann, C.A., York-Cooler, C., Simpson, S.G., Harkavy-Friedman, J., Reich, T. (1994). Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Archives of General Psychiatry, 51(11), 849859; discussion 863–844.
Paulsen, J.S., Romero, R., Chan, A., Davis, A.V., Heaton, R.K., Jeste, D.V. (1996). Impairment of the semantic network in schizophrenia. Psychiatry Research, 63(2–3), 109121.
Quesada, J. (2007). Creating your own LSA spaces. In T. Landauer, D.S. McNamara, S. Dennis, W. Kintsch (Eds.), Handbook of latent semantic analysis (pp. 7188). Mahwah, NJ: LEA.
Robert, P.H., Lafont, V., Medecin, I., Berthet, L., Thauby, S., Baudu, C., Darcourt, G. (1998). Clustering and switching strategies in verbal fluency tasks: Comparison between schizophrenics and healthy adults. Journal of the International Neuropsychological Society, 4(6), 539546.
Rossell, S.L., David, A.S. (2006). Are semantic deficits in schizophrenia due to problems with access or storage? Schizophrenia Research, 82(2–3), 121134.
Rossell, S.L., Rabe-Hesketh, S., Shapleske, J., David, A.S. (1999). Is semantic fluency differentially impaired in schizophrenic patients with delusions? Journal of Clinical and Experimental Neuropsychology, 21(5), 629642.
Schretlen, D.J., Cascella, N.G., Meyer, S.M., Kingery, L.R., Testa, S.M., Munro, C.A., Pearlson, G.D. (2007). Neuropsychological functioning in bipolar disorder and schizophrenia. Biological Psychiatry, 62(2), 179186.
Schretlen, D.J., Testa, S.M., Winicki, J.M., Pearlson, G.D., Gordon, B. (2008). Frequency and bases of abnormal performance by healthy adults on neuropsychological testing. Journal of the International Neuropsychological Society, 14(3), 436445.
Schretlen, D.J., Vannorsdall, T.D. (2010). Calibrated Ideational Fluency Assessment (CIFA) professional manual. Lutz, FL: Psychological Assessment Resources, Inc.
Schretlen, D.J., Winicki, J.M., Meyer, S.M., Testa, S.M., Pearlson, G.D., Gordon, B. (2009). Development, psychometric properties, and validity of the Hopkins Adult Reading Test (HART). Clinical Neuropsychologist, 23(6), 926943.
Spitzer, M., Maier, S., Weisbrod, M. (1997). A cognitive neuroscience view on formal thought disorder. Schizophrenia Research, 24(1–2), 137137.
Storms, G., Dirikx, T., Saerens, J., Verstraeten, S., De Deyn, P.P. (2003). On the use of scaling and clustering in the study of semantic deficits. Neuropsychology, 17(2), 289301.
Sumiyoshi, C., Sumiyoshi, T., Nohara, S., Yamashita, I., Matsui, M., Kurachi, M., Niwa, S. (2005). Disorganization of semantic memory underlies alogia in schizophrenia: An analysis of verbal fluency performance in Japanese subjects. Schizophrenia Research, 74(1), 91100.
Troyer, A.K., Moscovitch, M., Winocur, G. (1997). Clustering and switching as two components of verbal fluency: Evidence from younger and older healthy adults. Neuropsychology, 11(1), 138146.
Zakzanis, K.K., Troyer, A.K., Rich, J.B., Heinrichs, W. (2000). Component analysis of verbal fluency in patients with schizophrenia. Neuropsychiatry, Neuropsychology, and Behavioral Neurology, 13(4), 239245.

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Semantic Clustering of Category Fluency in Schizophrenia Examined with Singular Value Decomposition

  • Kyongje Sung (a1), Barry Gordon (a1) (a2), Tracy D. Vannorsdall (a3), Kerry Ledoux (a1), Erin J. Pickett (a1), Godfrey D. Pearlson (a4) (a5) and David J. Schretlen (a3) (a6)...

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